bicozamycin

Product Name: bicozamycin
CAS No.: 38129-37-2
Chemical Name: bicozamycin
Synonyms: C11259;WS-4545;ICOZAMYCIN;bicozamycin;BicycloMycin;BicozaMycin benzoate;BicozaMycin, AizuMycin, Bacteron, CGP 3543E, WS4545, 5879;(1R,6S)-1-hydroxy-2-methylidene-6-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione;2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-
CBNumber: CB0895983
Molecular Formula: C12H18N2O7
Formula Weight: 302.28
MOL File: 38129-37-2.mol

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bicozamycin Property

Melting point:: 188-191° (dec); mp 187-189° (dec) (Imanaka); mp 166-170° (Nakatsuka et al.)
alpha: D23 +63.5° (methanol)
Boiling point:: 786.6±60.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
pka: 9.85±0.60(Predicted)

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Safety

Toxicity: LD50 in mice: >4 g/kg (Williams, Durham)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0015110
Product name: BICOZAMYCIN
Purity: 95.00%
Packaging: 5MG
Price: $2203.43
Updated: 2021/12/16

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bicozamycin Chemical Properties,Usage,Production

Uses

Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.

Definition

ChEBI: A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.

Origin

Bicozamycin, formerly called bicyclomycin, was found independently in 1972, in the cul ture broth of Streptomyces sapporonensisbyFu jisawa Pharmaceuticals Industries and in that of S. aizuensis by Miyamura et al. of Ni igata University.

Biological Activity

Bicozamycin has a unique bicyclic structure and shows activity against Kleb siella, Salmonella, and Shigella but noneagainst other gram-negative bacteria or gram-positive microorganisms.

Safety

Bicozamycin is not absorbed orally and showsverylowtoxicity;nomicedied following its intravenous injection at a dose as high as two grams per kilogram.

bicozamycin Preparation Products And Raw materials

Raw materials

Preparation Products

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bicozamycin Suppliers

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38129-37-2, bicozamycinRelated Search:

Chloramphenicol Natamycin trans-2,5-Dimethylpiperazine CYCLO(-GLY-SER) (R)-2-ETHYL-PIPERAZINE bicozamycin CYCLO(-LEU-GLY) (S)-3-(2-HYDROXYETHYL)-2,5-DIKETOPIPERAZINE

bicozamycin

C11259

WS-4545

BicozaMycin benzoate

BicozaMycin, AizuMycin, Bacteron, CGP 3543E, WS4545, 5879

BicycloMycin

(1R,6S)-1-hydroxy-2-methylidene-6-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione

2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-

ICOZAMYCIN

38129-37-2