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2S,4R-Sacubitril

Product Name
2S,4R-Sacubitril
CAS No.
2307668-79-5
Chemical Name
2S,4R-Sacubitril
Synonyms
[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxobutyl)amino]-α-methyl-, 4-ethyl ester, (αR,γS)-rel-
CBNumber
CB09272710
Molecular Formula
C25H31NO5
Formula Weight
425.53
MOL File
2307668-79-5.mol
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2S,4R-Sacubitril Property

Boiling point:
658.5±55.0 °C(Predicted)
Density 
1.136±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
4.76±0.10(Predicted)
form 
Oil
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

A2B
Product number
BA33135
Product name
2S,4R-Sacubitril
Purity
99%
Packaging
1mg
Price
$685
Updated
2021/12/16
A2B
Product number
BA33135
Product name
2S,4R-Sacubitril
Purity
99%
Packaging
5mg
Price
$2035
Updated
2021/12/16
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2S,4R-Sacubitril Chemical Properties,Usage,Production

Description

2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

References

[1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.

2S,4R-Sacubitril Preparation Products And Raw materials

Raw materials

Preparation Products

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2S,4R-Sacubitril Suppliers

China 2 United States 1 Global 3
MedChemExpress
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Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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2307668-79-5, 2S,4R-SacubitrilRelated Search:

LCZ696(valsartan + sacubitril) impurity 35 [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)- LCZ696(valsartan + sacubitril) impurity 31 [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)- LCZ696(valsartan + sacubitril) impurity 34 Sacubatrava valsartan sodium hydrate Sacubitril Impurity 43 Sacubitril Sodium Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester Sacubitrilat-d5

  • [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxobutyl)amino]-α-methyl-, 4-ethyl ester, (αR,γS)-rel-
  • 2307668-79-5