ChemicalBook > CAS DataBase List > iproniazid

iproniazid

Product Name
iproniazid
CAS No.
54-92-2
Chemical Name
iproniazid
Synonyms
IPRAZID;Marsilid;iproniazid;Iproniazid>n’-isopropylisonicotinohydrazide;1-Isonicotinoyl-2-isopropylhydrazine;N'-Isopropylpyridine-4-Carbohydrazide;Isonicotinic Acid 2-Isopropylhydrazide;N'-propan-2-ylpyridine-4-carbohydrazide;Isonicotinic acid N'-isopropyl-hydrazide
CBNumber
CB0928533
Molecular Formula
C9H13N3O
Formula Weight
179.22
MOL File
54-92-2.mol
More
Less

iproniazid Property

Melting point:
112.5-113.5°
Boiling point:
311.75°C (rough estimate)
Density 
1.1305 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
11.28±0.23(Predicted)
form 
Solid
color 
Pale Beige
CAS DataBase Reference
54-92-2
More
Less

Safety

HS Code 
2933399990
Toxicity
An isopropyl derivative of isoniazid that was found to have mood-elevating effects in tuberculosis patients. It was later found to be a monoamine oxidase (MAO) inhibitor and, although not currently approved for clinical use as an antidepressant due to its propensity to cause liver damage it led to the development of other MAO inhibitors currently in use. In addition to hepatotoxic effects, iproniazid is a hypotensive agent and can cause potentially hazardous reactions with other drugs and amine-rich foods.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Usbiological
Product number
014945
Product name
Iproniazid
Packaging
500mg
Price
$446
Updated
2021/12/16
TRC
Product number
I746500
Product name
Iproniazid
Packaging
5g
Price
$1110
Updated
2021/12/16
Ark Pharm
Product number
AK161712
Product name
N'-Isopropylisonicotinohydrazide
Purity
97%
Packaging
100mg
Price
$9
Updated
2021/12/16
ChemScene
Product number
CS-0013623
Product name
Iproniazid
Purity
≥98.0%
Packaging
100mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
BI164580
Product name
Iproniazid
Packaging
100mg
Price
$50
Updated
2021/12/16
More
Less

iproniazid Chemical Properties,Usage,Production

Originator

Marsilid,Roche,US,1952

Uses

Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.

Definition

ChEBI: Iproniazid is a carbohydrazide and a member of pyridines.

Manufacturing Process

A mixture of 40 g of isonicotinyl hydrazine and 600 cc of acetone was heated on a steam bath until solution was complete. Upon cooling the reaction mixture, 1-isonicotinyl-2-isopropylidene hydrazine precipitated in the form of white needles; MP 161°C to 161.5°C.
A solution of 20 g of 1-isonicotinyl-2-isopropylidene hydrazine in 150 cc of methanol was reduced with hydrogen at room temperature and 50 psi using 300 mg of platinum black as a catalyst.

brand name

Euphozid;Ipropran;Isotamine;Laniazid;Marsilid;Nydrazid;P-1-n forte;Pms isoniazid;Rifamate;Rimactane;Rimifon;Ro 7-1554;Teebaconin;Triniad;Uniad.

Therapeutic Function

Antidepressant, Monoamine oxidase inhibitor

World Health Organization (WHO)

Iproniazid, a monoamine oxidase inhibitor (MAOI), was introduced in 1952 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus iproniazid remains available in several countries.

Purification Methods

Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.

iproniazid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

iproniazid Suppliers

Canada 1 China 68 Europe 1 Germany 1 India 5 Japan 1 United Kingdom 1 United States 12 Global 90
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 15881143215
Email
liangli@happysyn.com
Country
China
ProdList
1956
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25004
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6037 18920794737
Email
sales@heowns.com
Country
China
ProdList
23053
Advantage
60
Jinan Liheng Biotechnology Co., Ltd.
Tel
0531-18763987518 18763987518
Email
levi@lihengpharm.com
Country
China
ProdList
1788
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10789
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3960
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
10279
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
Country
China
ProdList
12005
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Nanjing Hengbei Chemicals Co., Ltd.
Tel
+86-25-58393656
Fax
+86-25-58393656
Email
sales@hengbeichem.cn
Country
China
ProdList
6854
Advantage
58
Honest Joy Holdings Limited
Tel
755-36694831 +8613798234863
Email
Linda.zhou@debayer.com
Country
China
ProdList
998
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
11725
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29810
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44458
Advantage
58
Shandong Tianming Biotechnology Development Co. Ltd
Tel
400-9019001
Country
China
ProdList
15069
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Guangzhou Yunmen Biotechnology Co., Ltd
Tel
18902340307 18902340307
Fax
0751-2819901
Email
3356812514@qq.com
Country
China
ProdList
9244
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Country
China
ProdList
9998
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
30016
Advantage
58
Zhengzhou Hong Sheng Pharmaceutical Technology Co. Ltd.
Tel
0371-55695890 15637198702
Email
1677336983@qq.com
Country
China
ProdList
13191
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Shanghai Yanbang Pharmaceutical Technology Co., Ltd
Tel
15618536883
Email
1228181347@qq.com
Country
China
ProdList
7988
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 15801958784
Email
lihua@jskchem.com
Country
China
ProdList
49234
Advantage
58
Liaocheng Lebote Biopharmaceutical Technology Co., Ltd
Tel
0635-893290 18663513896;
Email
28698871@qq.com
Country
China
ProdList
8539
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9266
Advantage
58
Shaoguan Qicheng Biotechnology Co., Ltd
Tel
18122215013
Email
780229652@qq.com
Country
China
ProdList
1176
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 13308200041
Email
2851167782@qq.com
Country
China
ProdList
11183
Advantage
58
Shanghai Time Chemicals CO., Ltd.
Tel
+86-021-57951555 +8617317452075
Fax
+86-021-57951555
Email
jack.li@time-chemicals.com
Country
China
ProdList
1803
Advantage
55
More
Less

View Lastest Price from iproniazid manufacturers

Honest Joy Holdings Limited
Product
iproniazid 54-92-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99.5%
Supply Ability
100 tons
Release date
2022-02-18
Career Henan Chemical Co
Product
iproniazid 54-92-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-18

54-92-2, iproniazidRelated Search:

Thionyl chloride 2-Chloropropane 2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol METHYL ISOINDOLINE-5-CARBOXYLATE HYDROCHLORIDE tert-Butyl isonicotinate Phenelzine Sulpiride PENTAZOCINE Carbamazepine ISOCARBOXAZID (200 MG) Clozapine Procaine hydrochloride LONICERAE JAPONICAE FLOS Moclobemide Chlorpromazine IPRONIAZID PHOSPHATE iproniazid N-(6,7-DIMETHOXY-1-(4-METHOXYPHENYL)-3-OXO-3,4-DIHYDROISOQUINOLIN-2(1H)-YL)ISONICOTINAMIDE

  • iproniazid
  • IPRAZID
  • N'-propan-2-ylpyridine-4-carbohydrazide
  • N'-Isopropylpyridine-4-Carbohydrazide
  • 4-Pyridinecarboxylicacid, 2-(1-methylethyl)hydrazide
  • Marsilid
  • Iproniazid&gt
  • 1-Isonicotinoyl-2-isopropylhydrazine
  • Isonicotinic Acid 2-Isopropylhydrazide
  • Isonicotinic acid N'-isopropyl-hydrazide
  • n’-isopropylisonicotinohydrazide
  • 54-92-2
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals