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Sulpiride

Product Name
Sulpiride
CAS No.
15676-16-1
Chemical Name
Sulpiride
Synonyms
Abilit;Dobren;Meresa;Eglonyl;Guastil;Miradol;Neogama;Omperan;Splotin;Synedil
CBNumber
CB4141314
Molecular Formula
C15H23N3O4S
Formula Weight
341.43
MOL File
15676-16-1.mol
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Sulpiride Property

Melting point:
178-180°
alpha 
D25 -66.8° (c = 0.5 in DMF)
Density 
1.2375 (rough estimate)
refractive index 
1.6320 (estimate)
storage temp. 
2-8°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
pka
pKa1 9.00, pKa2 10.19(at 25℃)
form 
powder
color 
yellow
Water Solubility 
<0.21g/L(25 ºC)
λmax
232nm(EtOH)(lit.)
Merck 
14,8989
InChIKey
BGRJTUBHPOOWDU-UHFFFAOYSA-N
CAS DataBase Reference
15676-16-1(CAS DataBase Reference)
NIST Chemistry Reference
Sulpiride(15676-16-1)
EPA Substance Registry System
Sulpiride (15676-16-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
BZ3400000
Toxicity
LD50 in mice (mg/kg): 170 i.p.; 2250 orally (Dostert)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S8010
Product name
(±)-Sulpiride
Packaging
25g
Price
$94.6
Updated
2020/08/18
Sigma-Aldrich
Product number
S2190000
Product name
Sulpiride
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
S8010
Product name
(±)-Sulpiride
Packaging
100g
Price
$334
Updated
2020/08/18
TCI Chemical
Product number
S0501
Product name
(±)-Sulpiride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$24
Updated
2021/03/22
TCI Chemical
Product number
S0501
Product name
(±)-Sulpiride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$67
Updated
2021/03/22
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Sulpiride Chemical Properties,Usage,Production

Chemical Properties

Sulpiride is White Solid

Originator

Dogmatil,Delagrange,France,1969

Uses

Sulpiride is an antipsychotic drug used in the treatment of Schozophrenia and depression.

Uses

dopamine receptor antagonist, antipsychotic

Uses

Sulpiride possesses moderate neuroleptic activity along with some stimulating and antidepressant effects. It has antiemetic, moderately cataleptogenic, and antiserotonin action. It facilitates increased blood flow in the stomach. It speeds up the restorative processes in tissues. It is used for schizophrenia, depression, migraines, disturbance of behavioral functions, and stomach and duodenal ulcers.

Definition

Sulpiride is a member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Manufacturing Process

1-Ethyl-2-aminomethylpyrrolidine is reacted with 2-methoxy-5- sulfamoylbenzoic acid to give sulpiride.

brand name

Dogmatyl (Laboratoires Delagrange, France).

Therapeutic Function

Tranquilizer, Digestive aid

Biological Activity

Standard D 2 -like dopamine receptor antagonist.

Chemical Synthesis

Sulpiride, N-[(1-ethyl-2-pirrolidinylmethyl]-5-sulfamoyl-O-anizamide (6.7.2), is synthesized from 5-aminosulfosalycilic acid. Methylating this with dimethylsulfate gives 2-methoxy-5-aminosulfonylbenzoic acid (6.7.1), which is transformed into an amide using 2-aminomethyl-1-ethylpyrrolidine as amine components and carbonyl-1,1′-bisimidazole as a condensing agent [70–74].

Sulpiride Preparation Products And Raw materials

Raw materials

Preparation Products

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Sulpiride Suppliers

Hubei YuanCheng SaiChuang Technology Co., Ltd.
Tel
021-68580270 18121115343
Fax
021-68580972
Email
foodinfo@yccreate.com
Country
China
ProdList
282
Advantage
55
Guangzhou Zeqin Pharmaceutical Technology Co. , Ltd.
Tel
Fax
3181266507@qq.c
Email
3181266507@qq.com
Country
China
ProdList
134
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18227
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19999
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8940
Advantage
52
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View Lastest Price from Sulpiride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Sulpiride 15676-16-1
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-12-03
Dideu Industries Group Limited
Product
Sulpiride USP/EP/BP 15676-16-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
Sulpiride 15676-16-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

15676-16-1, SulpirideRelated Search:


  • R.D. 1403
  • rac Sulpiride
  • (RS)-(+/-)-SULPIRIDE
  • (RS)-(+/-)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXYBENZAMIDE
  • (+/-)-SULPIRIDE
  • SULPIRIDE
  • Abilit
  • Aiglonyl
  • Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-
  • Coolspan
  • Dobren
  • Dogmatil
  • Dogmatyl
  • Dolmatil
  • Eglonyl
  • Guastil
  • Levobren
  • l-Forms: levosulpiride
  • Meresa
  • Miradol
  • Mirbanil
  • Misulvan
  • N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide
  • n-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamid
  • N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
  • Neogama
  • o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-
  • Omperan
  • Pyrikappl
  • Pyrkappl
  • Sulpiride COS
  • (+/-)-N-1-(ETHYLPYRROLIDIN-2-YLMETHYL)-2-METHOXY-5-SULFAMOYLBENZAMIDE
  • [+/-]-N-1-[ETHYLPYRROLIDIN-2-YLMETHYL]-2-METHOXY-5-SULFAMOYLBENZAMIDE
  • r.d.1403
  • Sernevin
  • Splotin
  • Sulpirid
  • Sulpitil
  • Sulpyrid
  • Sursumid
  • Synedil
  • 5-(aminosufonyl)-n-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
  • (+/-)-5-AMINOSULFONYL-N-([1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXY-BENZAMIDE
  • 5-(AMINOSULFONYL)-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXY-BENZAMIDE
  • Dogmatilum
  • Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- (9CI)
  • DL-Sulpiride
  • N-(1-Ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-sulfamidobenzamide
  • o-Anisamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl- (8CI)
  • (+/-)SULPIRIDE DOPAMINE D2 ANTAGONIS
  • (±)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide, (±)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
  • (±)-Sulpiride,(±)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, (±)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide
  • (+)-N-[[(2R)-1-Ethyl-2-pyrrolidinyl]methyl]-5-sulfamoyl-2-methoxybenzamide
  • ulpiride
  • N-{[(2S)-1-ethylpyrrolidin-2-yl]Methyl}-2-Methoxy-5-sulfaMoylbenzaMide
  • (RS)-(&#177
  • 2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic Acid Hydrochloride
  • N-[[(2R)-1-ethyl-2-pyrrolidin-1-iumyl]methyl]-2-methoxy-5-sulfamoylbenzamide