Sulpiride
- Product Name
- Sulpiride
- CAS No.
- 15676-16-1
- Chemical Name
- Sulpiride
- Synonyms
- Abilit;Dobren;Meresa;Eglonyl;Guastil;Miradol;Neogama;Omperan;Splotin;Synedil
- CBNumber
- CB4141314
- Molecular Formula
- C15H23N3O4S
- Formula Weight
- 341.43
- MOL File
- 15676-16-1.mol
Sulpiride Property
- Melting point:
- 178-180°
- alpha
- D25 -66.8° (c = 0.5 in DMF)
- Density
- 1.2375 (rough estimate)
- refractive index
- 1.6320 (estimate)
- storage temp.
- 2-8°C
- solubility
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
- form
- powder
- pka
- pKa1 9.00, pKa2 10.19(at 25℃)
- color
- yellow
- Water Solubility
- <0.21g/L(25 ºC)
- λmax
- 232nm(EtOH)(lit.)
- Merck
- 14,8989
- InChIKey
- BGRJTUBHPOOWDU-UHFFFAOYSA-N
- LogP
- 0.57
- CAS DataBase Reference
- 15676-16-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Sulpiride(15676-16-1)
- EPA Substance Registry System
- Sulpiride (15676-16-1)
N-Bromosuccinimide Price
- Product number
- S8010
- Product name
- (±)-Sulpiride
- Packaging
- 25g
- Price
- $117
- Updated
- 2024/03/01
- Product number
- S8010
- Product name
- (±)-Sulpiride
- Packaging
- 100g
- Price
- $414
- Updated
- 2024/03/01
- Product number
- BP679
- Product name
- Sulpiride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $259
- Updated
- 2023/06/20
- Product number
- S0501
- Product name
- (±)-Sulpiride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $36
- Updated
- 2024/03/01
- Product number
- S0501
- Product name
- (±)-Sulpiride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $144
- Updated
- 2024/03/01
Sulpiride Chemical Properties,Usage,Production
Chemical Properties
Sulpiride is White Solid
Originator
Dogmatil,Delagrange,France,1969
Uses
Sulpiride is an antipsychotic drug used in the treatment of Schozophrenia and depression.
Uses
dopamine receptor antagonist, antipsychotic
Uses
Sulpiride possesses moderate neuroleptic activity along with some stimulating and antidepressant effects. It has antiemetic, moderately cataleptogenic, and antiserotonin action. It facilitates increased blood flow in the stomach. It speeds up the restorative processes in tissues. It is used for schizophrenia, depression, migraines, disturbance of behavioral functions, and stomach and duodenal ulcers.
Definition
Sulpiride is a member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Manufacturing Process
1-Ethyl-2-aminomethylpyrrolidine is reacted with 2-methoxy-5- sulfamoylbenzoic acid to give sulpiride.
brand name
Dogmatyl (Laboratoires Delagrange, France).
Therapeutic Function
Tranquilizer, Digestive aid
Biological Activity
Standard D 2 -like dopamine receptor antagonist.
Biochem/physiol Actions
(±)-Sulpiride is a D2 dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D2-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.45,46
Clinical Use
Antipsychotic:
Acute and chronic schizophrenia
Synthesis
Sulpiride, N-[(1-ethyl-2-pirrolidinylmethyl]-5-sulfamoyl-O-anizamide (6.7.2), is synthesized from 5-aminosulfosalycilic acid. Methylating this with dimethylsulfate gives 2-methoxy-5-aminosulfonylbenzoic acid (6.7.1), which is transformed into an amide using 2-aminomethyl-1-ethylpyrrolidine as amine components and carbonyl-1,1??-bisimidazole as a condensing agent [70¨C74].
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with
tramadol; enhanced hypotensive and sedativeeffects with opioids; increased risk of ventricular
arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular
arrhythmias with anti-arrhythmics that prolong the
QT interval, e.g. procainamide, disopyramide and
amiodarone - avoid with amiodarone.
Antibacterials: increased risk of ventricular
arrhythmias with moxifloxacin and parenteral
erythromycin - avoid with moxifloxacin.
Antidepressants: possibly increased risk of
ventricular arrhythmias and antimuscarinic side
effects with tricyclics - avoid.
Antiepileptics: antagonism (convulsive threshold
lowered).
Antimalarials: avoid with artemether/lumefantrine.
Antipsychotics: increased risk of ventricular
arrhythmias with droperidol, haloperidol and
pimozide - avoid; possible increased risk of
ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased by
ritonavir.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular
arrhythmias.
Beta-blockers: enhanced hypotensive effect;
increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias
with vandetanib - avoid; increased risk of ventricular
arrhythmias with arsenic trioxide.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects
and possibly neurotoxicity.
Pentamidine: increased risk of ventricular
arrhythmias.
Metabolism
Sulpiride undergoes little metabolism.
95% of a dose is excreted in the urine and faeces, mainly
as unchanged drug.
storage
Room temperature
Sulpiride Preparation Products And Raw materials
Raw materials
Preparation Products
Sulpiride Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8843
- Advantage
- 52
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 021-51613915-820 13611835272
- Fax
- 021 51613951
- mmwang@sunwaypharm.cn
- Country
- China
- ProdList
- 9734
- Advantage
- 57
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2871
- Advantage
- 58
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4940
- Advantage
- 60
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 27-81302488 18007166089
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 2024
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 021-54359730 400-008-9730
- Fax
- 021-54353864
- info@chemxyz.com
- Country
- China
- ProdList
- 3991
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18042
- Advantage
- 56
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7887
- Advantage
- 56
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4943
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 16166
- Advantage
- 55
- Tel
- 027-59420981,18702770802
- Fax
- 027-83322098
- Country
- China
- ProdList
- 1975
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9958
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4891
- Advantage
- 55
- Tel
- 027-59207879 1972026995 18140587686
- Fax
- QQ：1972026995
- sales@3600chem.com
- Country
- China
- ProdList
- 4668
- Advantage
- 55
- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20806
- Advantage
- 60
- Tel
- sales@njromanme.com
- Country
- China
- ProdList
- 4529
- Advantage
- 58
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 18126413629 0755-23311925 2355327053
- Fax
- 0755-23311925
- abel@ycgmp.com
- Country
- China
- ProdList
- 5113
- Advantage
- 58
- Tel
- 027-83856981
- Fax
- 15807174745
- 1498703467@qq.com
- Country
- China
- ProdList
- 244
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 18124570582 TEL：0755-23574479 2355327139
- Fax
- 0755-23229476 QQ: 2355327139
- siliao02@yccreate.com
- Country
- China
- ProdList
- 6116
- Advantage
- 58
- Tel
- 027-59402396 13419635609
- Fax
- 027-83989310
- 13419635609@163.com
- Country
- China
- ProdList
- 1973
- Advantage
- 55
- Tel
- 18171081685
- Fax
- 027-83219882
- 2834045742@qq.com
- Country
- China
- ProdList
- 313
- Advantage
- 58
- Tel
- 021-36031160 13311776681
- 3338195766@QQ.com
- Country
- China
- ProdList
- 5175
- Advantage
- 55
View Lastest Price from Sulpiride manufacturers
- Product
- Sulpiride 15676-16-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 300KG/month
- Release date
- 2023-01-10
- Product
- Sulpiride 15676-16-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- USP
- Supply Ability
- 5,000KG
- Release date
- 2024-07-25
- Product
- Sulpiride 15676-16-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-17