2-(methylsulphonyl)-10H-phenothiazine
- Product Name
- 2-(methylsulphonyl)-10H-phenothiazine
- CAS No.
- 23503-68-6
- Chemical Name
- 2-(methylsulphonyl)-10H-phenothiazine
- Synonyms
- Einecs 245-701-4;2-(Methylsulfonyl);Metopimazine Impurity 2;2-Methylsulfonyl phenothiazine;2-Methylsulfonyl-10H-phenothiazine;10H-Phenothiazine,2-(Methylsulfonyl);2-(methylsulphonyl)-10H-phenothiazine
- CBNumber
- CB0933687
- Molecular Formula
- C13H11NO2S2
- Formula Weight
- 277.36
- MOL File
- 23503-68-6.mol
2-(methylsulphonyl)-10H-phenothiazine Property
- Melting point:
- 156.5-158.0 °C
- Boiling point:
- 524.1±50.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -3.17±0.20(Predicted)
- color
- Light Yellow to Green
Safety
- HS Code
- 2934309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M326625
- Product name
- 2-(Methylsulfonyl)Phenothiazine
- Packaging
- 100mg
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- 36068
- Product name
- 2-(Methylsulfonyl)-10H-phenothiazine
- Purity
- 95+%
- Packaging
- 5G
- Price
- $610
- Updated
- 2021/12/16
- Product number
- 1579AB
- Product name
- 2-(Methylsulfonyl)-10H-phenothiazine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 8H70-1-M8
- Product name
- 2-(Methylsulfonyl)-10H-phenothiazine
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CS-0100723
- Product name
- 2-(Methylsulfonyl)-10H-phenothiazine
- Packaging
- 5g
- Price
- $319
- Updated
- 2021/12/16
2-(methylsulphonyl)-10H-phenothiazine Chemical Properties,Usage,Production
Chemical Properties
Green Solid
Uses
Phenothiazine (P318040) derivative.
Synthesis
1628-29-1
124-63-0
23503-68-6
A mixture of aluminum trichloride (0.17 g, 1.24 mmol) and methanesulfonyl chloride (0.17 mL, 2.34 mmol) in dichloromethane (20 mL) was stirred for 15 min at 0 °C, followed by the addition of 1-(10H-phenothiazin-10-yl)ethanone (0.30 g, 1.24 mmol). The reaction mixture was stirred at room temperature for 24 h, followed by dilution with ice-cold H2O and extraction with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using hexane/ethyl acetate (65:35, v/v) as eluent. 2-(Methylsulfonyl)-10H-phenothiazine (product 18) was obtained as a green solid in 28% (96 mg) yield; melting point: 211-215 °C (hexane/ethyl acetate); IR (ATR diamond, cm-1 ) ν: 3351, 1567, 1310, 1297; 1H NMR (400 MHz, acetone-d6) δ: 3.22 (s, 3H, CH3), 6.90 (d, J = 9 Hz, 1H, H-9), 6.98 (d, J = 9 Hz, 1H, H-6), 7.03 (t, J = 9 Hz, 1H, H-7), 7.13 (d, J = 6 Hz, 1H, H-3), 7.20 (t, J = 9 Hz, 1H, H-8), 7.58 (s, 1H H-1), 7.66 (d, J = 6 Hz, 1H, H-4), 8.55 (bs, 1H, NH); 13C NMR (100 MHz, acetone-d6) δ: 44.2 (CH3), 114.5 (CH), 115.6 (CH), 116.9 (Cq), 118.7 (Cq), 123.8 (CH), 125.9 ( CH), 126.8 (CH), 127.8 (CH), 128.4 (CH), 134.7 (Cq), 140.9 (Cq), 147.2 (Cq).HRMS (ESI): Calculated value of C13H12NO2S2 [M + H]+: 278.0309, Measured value 278.0310.
References
[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 14, p. 4113 - 4126
2-(methylsulphonyl)-10H-phenothiazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(methylsulphonyl)-10H-phenothiazine manufacturers
- Product
- 2-(methylsulphonyl)-10H-phenothiazine 23503-68-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2020-01-02