metopimazine

Product Name: metopimazine
CAS No.: 14008-44-7
Chemical Name: metopimazine
Synonyms: NG101;NG 101;NG-101;RP-9965;EXP 999;9965 RP;Nortrip;Vogalene;metopimazine;metopimazine USP/EP/BP
CBNumber: CB0934482
Molecular Formula: C22H27N3O3S2
Formula Weight: 445.59808
MOL File: 14008-44-7.mol

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metopimazine Property

Melting point:: 170.5℃
Boiling point:: 721.2±60.0 °C(Predicted)
Density: 1.1920 (rough estimate)
refractive index: 1.6320 (estimate)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 16.44±0.20(Predicted)
color: Pale Yellow
CAS DataBase Reference: 14008-44-7

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Safety

Toxicity: LD50 in male rats (mg/kg): 976 orally, 1080 s.c. (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M338760
Product name: Metopimazine
Packaging: 50mg
Price: $1695
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008052
Product name: METOPIMAZINE
Purity: 95.00%
Packaging: 50MG
Price: $1871.1
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008052
Product name: METOPIMAZINE
Purity: 95.00%
Packaging: 5MG
Price: $385
Updated: 2021/12/16

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metopimazine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Originator

Nortrip,Rhodia

Uses

Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.

Uses

metopimazine is used to prevent emesis during chemotherapies.

Definition

ChEBI: Metopimazine is a member of phenothiazines.

Manufacturing Process

2-Methylsulfonyl-10-(3-chloropropyl)phenothiazine was prepared by condensation of 1-bromo-3-chloropropane and 2-methylsulfonyl phenothiazine in liquid ammonia in presence of obtained in situ sodium amide.
10 g 2-methylsulfonyl-10-(3-chloropropyl)-phenothiazine, 4 g piperidine-4- carboxylic acid amide, 3.5 g dry sodium carbonate in 200 ml of ethanol was heated to reflux for 24 hours. Than 1.75 g sodium carbonate was added and the mixture was heated another 8 hours. After that the new 1.75 g portion of sodium carbonate was added and heated for 16 hours. The solvent was removed in vacuum (20 mm Hg). The residue was stirred with 50 ml water and 150 ml ethyl acetate. The organic layer was separated and extracted with 200 ml 1 N hydrochloric acid. The water layer was made alkaline with 4 N sodium hydroxide, extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed in vacuum (20 mm Hg) to dryness. The obtained residue 2-methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine was recrystallized from ethyl acetate. Yield 6 g; MP: 170°-171°C.

Therapeutic Function

Antiemetic

metopimazine Preparation Products And Raw materials

Raw materials

Preparation Products

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metopimazine Suppliers

Canada 1 China 42 Europe 1 France 1 Germany 1 India 5 South Korea 1 United States 6 Global 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
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BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
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Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
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Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
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Country: China
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Shanghai Raise Chemical Technology Co.,Ltd

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Country: China
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Shanghai HuanChuan Industry Co.,Ltd.

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Chizhou Kailong Import and Export Trade Co., Ltd.

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Shanghai Synchem Pharma Co., ltd

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Cck Pharmchem Co.,Ltd

Tel: 0512-68131995 13862051930
Fax: 0512-68131995
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14008-44-7, metopimazineRelated Search:

Cetirizine dihydrochloride Stugeron Tropisetron ONDANSETRON FOR LC SYSTEM SUITABILITY Phloroglucinol metopimazine 3-(4-METHYL-PIPERIDIN-1-YL)-PROPYLAMINE 1-(3-AMINO-PROPYL)-PIPERIDINE-4-CARBOXYLIC ACID AMIDE 2-Methylthiophenothiazine

metopimazine

1-[3-[2-[Methylsulfonyl] phenothiazin-10-yl] propyl] isonipecotamide

1-[3-(2-Methylsulfonyl-10H-phenothiazin-10-yl)propyl]-4-piperidinecarboxamide

9965 RP

EXP 999

RP-9965

Vogalene

1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]piperidin-4-carboxaMide

2-Methylsulfonyl-10-[3-(4-carbamoylpiperidino)propyl]phenothiazine

4-PiperidinecarboxaMide,1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-

1-(3-(2-(methylsulfonyl)-10H-phenothiazin-10-yl)propyl)piperidine-4-carboxamide

1-[3-(2-Methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxaMide

metopimazine USP/EP/BP

NG 101

NG101

NG-101

Nortrip

14008-44-7

C22H21D6N3O3S2

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Isotope Labelled Compounds