ChemicalBook > CAS DataBase List > metopimazine
metopimazine
- Product Name
- metopimazine
- CAS No.
- 14008-44-7
- Chemical Name
- metopimazine
- Synonyms
- NG101;NG 101;NG-101;RP-9965;EXP 999;9965 RP;Nortrip;Vogalene;metopimazine;metopimazine USP/EP/BP
- CBNumber
- CB0934482
- Molecular Formula
- C22H27N3O3S2
- Formula Weight
- 445.59808
- MOL File
- 14008-44-7.mol
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metopimazine Property
- Melting point:
- 170.5℃
- Boiling point:
- 721.2±60.0 °C(Predicted)
- Density
- 1.1920 (rough estimate)
- refractive index
- 1.6320 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 16.44±0.20(Predicted)
- color
- Pale Yellow
- CAS DataBase Reference
- 14008-44-7
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Safety
- Toxicity
- LD50 in male rats (mg/kg): 976 orally, 1080 s.c. (Goldenthal)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
TRC
- Product number
- M338760
- Product name
- Metopimazine
- Packaging
- 50mg
- Price
- $1695
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0008052
- Product name
- METOPIMAZINE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1871.1
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0008052
- Product name
- METOPIMAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $385
- Updated
- 2021/12/16
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metopimazine Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Originator
Nortrip,Rhodia
Uses
Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.
Uses
metopimazine is used to prevent emesis during chemotherapies.
Definition
ChEBI: Metopimazine is a member of phenothiazines.
Manufacturing Process
2-Methylsulfonyl-10-(3-chloropropyl)phenothiazine was prepared by
condensation of 1-bromo-3-chloropropane and 2-methylsulfonyl phenothiazine
in liquid ammonia in presence of obtained in situ sodium amide.
10 g 2-methylsulfonyl-10-(3-chloropropyl)-phenothiazine, 4 g piperidine-4-
carboxylic acid amide, 3.5 g dry sodium carbonate in 200 ml of ethanol was
heated to reflux for 24 hours. Than 1.75 g sodium carbonate was added and
the mixture was heated another 8 hours. After that the new 1.75 g portion of
sodium carbonate was added and heated for 16 hours. The solvent was
removed in vacuum (20 mm Hg). The residue was stirred with 50 ml water
and 150 ml ethyl acetate. The organic layer was separated and extracted with
200 ml 1 N hydrochloric acid. The water layer was made alkaline with 4 N
sodium hydroxide, extracted with ethyl acetate and dried over sodium sulfate.
The solvent was removed in vacuum (20 mm Hg) to dryness. The obtained
residue 2-methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine
was recrystallized from ethyl acetate. Yield 6 g; MP: 170°-171°C.
Therapeutic Function
Antiemetic
metopimazine Preparation Products And Raw materials
Raw materials
Preparation Products
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