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metopimazine

Product Name
metopimazine
CAS No.
14008-44-7
Chemical Name
metopimazine
Synonyms
NG101;NG 101;NG-101;RP-9965;EXP 999;9965 RP;Nortrip;Vogalene;metopimazine;metopimazine USP/EP/BP
CBNumber
CB0934482
Molecular Formula
C22H27N3O3S2
Formula Weight
445.59808
MOL File
14008-44-7.mol
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metopimazine Property

Melting point:
170.5℃
Boiling point:
721.2±60.0 °C(Predicted)
Density 
1.1920 (rough estimate)
refractive index 
1.6320 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
16.44±0.20(Predicted)
color 
Pale Yellow
CAS DataBase Reference
14008-44-7
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Safety

Toxicity
LD50 in male rats (mg/kg): 976 orally, 1080 s.c. (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M338760
Product name
Metopimazine
Packaging
50mg
Price
$1695
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008052
Product name
METOPIMAZINE
Purity
95.00%
Packaging
50MG
Price
$1871.1
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008052
Product name
METOPIMAZINE
Purity
95.00%
Packaging
5MG
Price
$385
Updated
2021/12/16
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metopimazine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Originator

Nortrip,Rhodia

Uses

Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.

Uses

metopimazine is used to prevent emesis during chemotherapies.

Definition

ChEBI: Metopimazine is a member of phenothiazines.

Manufacturing Process

2-Methylsulfonyl-10-(3-chloropropyl)phenothiazine was prepared by condensation of 1-bromo-3-chloropropane and 2-methylsulfonyl phenothiazine in liquid ammonia in presence of obtained in situ sodium amide.
10 g 2-methylsulfonyl-10-(3-chloropropyl)-phenothiazine, 4 g piperidine-4- carboxylic acid amide, 3.5 g dry sodium carbonate in 200 ml of ethanol was heated to reflux for 24 hours. Than 1.75 g sodium carbonate was added and the mixture was heated another 8 hours. After that the new 1.75 g portion of sodium carbonate was added and heated for 16 hours. The solvent was removed in vacuum (20 mm Hg). The residue was stirred with 50 ml water and 150 ml ethyl acetate. The organic layer was separated and extracted with 200 ml 1 N hydrochloric acid. The water layer was made alkaline with 4 N sodium hydroxide, extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed in vacuum (20 mm Hg) to dryness. The obtained residue 2-methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine was recrystallized from ethyl acetate. Yield 6 g; MP: 170°-171°C.

Therapeutic Function

Antiemetic

metopimazine Preparation Products And Raw materials

Raw materials

Preparation Products

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14008-44-7, metopimazineRelated Search:

Cetirizine dihydrochloride Stugeron Tropisetron ONDANSETRON FOR LC SYSTEM SUITABILITY Phloroglucinol metopimazine 3-(4-METHYL-PIPERIDIN-1-YL)-PROPYLAMINE 1-(3-AMINO-PROPYL)-PIPERIDINE-4-CARBOXYLIC ACID AMIDE 2-Methylthiophenothiazine

  • metopimazine
  • 1-[3-[2-[Methylsulfonyl] phenothiazin-10-yl] propyl] isonipecotamide
  • 1-[3-(2-Methylsulfonyl-10H-phenothiazin-10-yl)propyl]-4-piperidinecarboxamide
  • 9965 RP
  • EXP 999
  • RP-9965
  • Vogalene
  • 1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]piperidin-4-carboxaMide
  • 2-Methylsulfonyl-10-[3-(4-carbamoylpiperidino)propyl]phenothiazine
  • 4-PiperidinecarboxaMide,1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-
  • 1-(3-(2-(methylsulfonyl)-10H-phenothiazin-10-yl)propyl)piperidine-4-carboxamide
  • 1-[3-(2-Methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxaMide
  • metopimazine USP/EP/BP
  • NG 101
  • NG101
  • NG-101
  • Nortrip
  • 14008-44-7
  • C22H21D6N3O3S2
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Isotope Labelled Compounds