ChemicalBook > CAS DataBase List > Selamectin

Selamectin

Product Name
Selamectin
CAS No.
220119-17-5
Chemical Name
Selamectin
Synonyms
Skudin;Siratine;Silamycin;Stronghold;Selamectin;Selamection;Seragliptin;Selamectin（b）;Selamectin CRS;hypnocarpic acid
CBNumber
CB0947411
Molecular Formula
C43H63NO11
Formula Weight
769.97
MOL File
220119-17-5.mol
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Selamectin Property

Melting point:
>180°C
Boiling point:
917.0±65.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly)
pka
10.34±0.70(Predicted)
color 
White to Yellow
Stability:
Hygroscopic
InChIKey
AFJYYKSVHJGXSN-KAJWKRCWSA-N
CAS DataBase Reference
220119-17-5
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Safety

WGK Germany 
3
HS Code 
2932206000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
32476
Product name
Selamectin
Purity
VETRANAL
Packaging
10mg
Price
$575
Updated
2024/03/01
Sigma-Aldrich
Product number
1611729
Product name
Selamectin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
350mg
Price
$2150
Updated
2024/03/01
Cayman Chemical
Product number
21529
Product name
Selamectin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21529
Product name
Selamectin
Purity
≥98%
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
21529
Product name
Selamectin
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
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Selamectin Chemical Properties,Usage,Production

Description

Selamectin is formulated as a spot-on for cats and dogs to control fleas (Ctenocephalides spp.) and flea-allergy dermatitis, to prevent heartworm disease, and to control ear mites (Otodectes cynotes) in cats and dogs. It is also approved for the treatment and control of sarcoptic mange (Sarcoptes scabiei) in dogs and hookworms (Ancylostoma tubaeformis) and roundworms (Toxocara cati) in cats.

Description

Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. At 0.1 μg/ml, selamectin is reported to inhibit growth in an H. contortus larval development assay.

Uses

Selamectin is a topical parasiticide and also used as a veterinary antihelminithic agent on animals.

Uses

Selamectin is a semi-synthetic avermectin derivative prepared by selective hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of endo- and exo- parasites of domestic animals, notably cats and dogs. Like the other milbemycin/avermectins, selamectin selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.

Definition

ChEBI: Selamectin is a milbemycin.

Veterinary Drugs and Treatments

Topical selamectin (Revolution?—Pfizer) is indicated for flea infestations (Ctenocephalides felis), prevention of heartworm disease (Dirofilaria immitis), and for ear mites (Otodectes cynotis) in both dogs and cats. Additionally in dogs, it is indicated for sarcoptic mange (Sarcoptes scabeii), and tick infestations (Dermacentor variabilis). In cats: hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati). The product (Revolution?) is labeled as not effective against either adult heartworms or clearing circulating microfilaria, but it possibly may have some efficacy with prolonged, continuous administration (Atkins 2007b).

Toxicity evaluation

Acute oral LD50 for rats: >1,600 mg/kg

Selamectin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Selamectin manufacturers

Sinoway Industrial co., ltd.
Product
Selamectin 220119-17-5
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2022-08-26
Hebei Duling International Trade Co. LTD
Product
Selamectin 220119-17-5
Price
US $13.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-06-11
Hebei Guanlang Biotechnology Co., Ltd.
Product
Selamectin 220119-17-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 MT
Release date
2023-04-07

220119-17-5, SelamectinRelated Search:

Diaquo[(1R,2R)-1,2-cyclohexanediaMine]platinuM DiMer Dinitrate OXALIC ACID Nitroclofene acepromazine Imidacloprid Amitraz Moxidectin Ascomycin Succinylcholine Chloride Terbinafine Hydrochloride Selamectin FEMA 3693

  • Selamectin
  • AverMectin A1a,25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-Methyl-a-L-arabino-hexopyranosyl)-5-deMethoxy-25-de(1-Methylpropyl)-22,23-dihydro-5-(hydroxyiMino)-,(5Z)-
  • hypnocarpic acid
  • (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-avermectin A1a
  • Revolution (antibiotic)
  • Stronghold
  • Selamectin CRS
  • Avermectin A1a, 25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-, (5Z)-
  • Oxaliplatin Impurity5（EP Impurity D）
  • selamectin ceutical
  • Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-...
  • Selamection
  • Selamectin (1611729)
  • Sierra rhzomorph
  • Skudin
  • (2R,2a'E,2a1'S,4'E,5S,6S,6'S,7'S,8'E,11'R,15'S,17a'R,20'Z,20a'R)-6-Cyclohexyl-2a1'-hydroxy-7'-(((2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-20'-(hydroxyimino)-5,6',8',19'-tetramethyl-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
  • Selamectin（b）
  • (2R,2a'E,2a1'S,4'E,5S,6S,6'S,7'S,8'E,11'R,15'S,17a'R,20'Z,20a'R)-6-Cyclohexyl-2a1'-hydroxy-7'-(((2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-20'-(hydroxyimino)-5,6',8',19'-tetramethyl-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
  • Seragliptin
  • Silamycin
  • Siratine
  • 220119-17-5
  • C43H63NO11
  • Anthelmintic
  • ectoparasiticide
  • API
  • 220119-17-5