Pyroxamide

Product Name: Pyroxamide
CAS No.: 382180-17-8
Chemical Name: Pyroxamide
Synonyms: Pyroxamide;NSC 696085;Pyroxamide PyroxaMide (NSC 696085);Pyroxamide, 10 mM in DMSO;Pyroxamide ISO 9001：2015 REACH;N-Hydroxy-N'-3-pyridinyloctanediamide;N1-Hydroxy-N8-3-pyridinyl-octanediamide;n-hydroxy-n'-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-
CBNumber: CB0950394
Molecular Formula: C13H19N3O3
Formula Weight: 265.31
MOL File: 382180-17-8.mol

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Pyroxamide Property

storage temp.: -20°C
solubility: DMSO: soluble10mg/mL (clear solution)
form: powder
color: white to beige
InChI: 1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)
InChIKey: PTJGLFIIZFVFJV-UHFFFAOYSA-N
SMILES: ONC(=O)CCCCCCC(=O)Nc1cccnc1

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0296
Product name: Pyroxamide
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $117
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0296
Product name: Pyroxamide
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $407
Updated: 2022/05/15

Cayman Chemical

Product number: 13870
Product name: Pyroxamide
Purity: ≥95%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 13870
Product name: Pyroxamide
Purity: ≥95%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 13870
Product name: Pyroxamide
Purity: ≥95%
Packaging: 25mg
Price: $250
Updated: 2024/03/01

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Pyroxamide Chemical Properties,Usage,Production

Description

Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC₅₀ = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.

Uses

Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.

Uses

Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

Definition

ChEBI: N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.

IC 50

HDAC1: 100 nM (ID₅₀)

storage

-20°C

References

[1]. butler lm, webb y, agus db, et al. inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. clin cancer res, 2001, 7(4): 962-970.
[2]. kutko mc, glick rd, butler lm, et al. histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. clin cancer res, 2003, 9(15): 5749-5755.

Pyroxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyroxamide Suppliers

Canada 1 China 92 India 1 South Korea 1 United Kingdom 1 United States 17 Global 113

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8667
Advantage: 57

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Email: 2819742715@qq.com
Country: China
ProdList: 4001
Advantage: 55

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19906
Advantage: 55

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3636
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

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View Lastest Price from Pyroxamide manufacturers

Dideu Industries Group Limited

Product: Pyroxamide 382180-17-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

Career Henan Chemical Co

Product: Pyroxamide 382180-17-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-20

382180-17-8, PyroxamideRelated Search:

CHLOROPHOSPHONAZO III 2-HYDROXYACETAMIDE N-Methylformamide 3-Hydroxypyridine Polyacrylamide N,N-Dimethylformamide Pyroxamide

382180-17-8; NSC-696085; N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE; N-HYDROXY-N'-(PYRIDIN-3-YL)OCTANEDIAMIDE; NSC696085; NSC 696085

n-hydroxy-n'-(pyridin-3-yl)octanediamide

NSC 696085

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PyroxaMide (NSC 696085)

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N1-Hydroxy-N8-(pyridin-3-yl)octanediamide

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N-Hydroxy-N'-3-pyridinyloctanediamide

Pyroxamide

PYROXAMIDE, N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE

Pyroxamide ISO 9001：2015 REACH

HDAC1,inhibit,Apoptosis,Histone deacetylases,Pyroxamide,leukemia,HDAC,Inhibitor

Pyroxamide, 10 mM in DMSO

Pyroxamide, N-Hydroxy-N'-3-pyridinyloctanediamide

382180-17-8