Pyroxamide
- Product Name
- Pyroxamide
- CAS No.
- 382180-17-8
- Chemical Name
- Pyroxamide
- Synonyms
- Pyroxamide;NSC 696085;Pyroxamide PyroxaMide (NSC 696085);Pyroxamide ISO 9001：2015 REACH;N-Hydroxy-N'-3-pyridinyloctanediamide;N1-Hydroxy-N8-3-pyridinyl-octanediamide;n-hydroxy-n'-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-;N1-Hydroxy-N8-(pyridin-3-yl)octanediamide
- CBNumber
- CB0950394
- Molecular Formula
- C13H19N3O3
- Formula Weight
- 265.31
- MOL File
- 382180-17-8.mol
Pyroxamide Property
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL (clear solution)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0296
- Product name
- Pyroxamide
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $114
- Updated
- 2024/03/01
- Product number
- SML0296
- Product name
- Pyroxamide
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $407
- Updated
- 2022/05/15
- Product number
- 13870
- Product name
- Pyroxamide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 13870
- Product name
- Pyroxamide
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 13870
- Product name
- Pyroxamide
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $250
- Updated
- 2024/03/01
Pyroxamide Chemical Properties,Usage,Production
Description
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-
Uses
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.
Uses
Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
Definition
ChEBI: N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.
storage
-20°C
References
[1]. butler lm, webb y, agus db, et al. inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. clin cancer res, 2001, 7(4): 962-970.
[2]. kutko mc, glick rd, butler lm, et al. histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. clin cancer res, 2003, 9(15): 5749-5755.
Pyroxamide Preparation Products And Raw materials
Raw materials
Preparation Products
Pyroxamide Suppliers
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- Fax
- 86-21-57758967
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- China
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- 021 51613951
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- Country
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View Lastest Price from Pyroxamide manufacturers
- Product
- Pyroxamide 382180-17-8
- Price
- US $0.50/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20
- Release date
- 2022-11-22
- Product
- Pyroxamide 382180-17-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-26
- Product
- Pyroxamide 382180-17-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-20