Pyroxamide

ChemicalBook > CAS DataBase List > Pyroxamide

Product Name: Pyroxamide
CAS No.: 382180-17-8
Chemical Name: Pyroxamide
Synonyms: Pyroxamide;NSC 696085;Pyroxamide PyroxaMide (NSC 696085);Pyroxamide ISO 9001：2015 REACH;N-Hydroxy-N'-3-pyridinyloctanediamide;N1-Hydroxy-N8-3-pyridinyl-octanediamide;n-hydroxy-n'-(pyridin-3-yl)octanediamide;N-hydroxy-N'-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-
CBNumber: CB0950394
Molecular Formula: C13H19N3O3
Formula Weight: 265.31
MOL File: 382180-17-8.mol

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Pyroxamide Property

storage temp.: -20°C
solubility: DMSO: soluble10mg/mL (clear solution)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0296
Product name: Pyroxamide
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0296
Product name: Pyroxamide
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $407
Updated: 2022/05/15

Cayman Chemical

Product number: 13870
Product name: Pyroxamide
Purity: ≥95%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 13870
Product name: Pyroxamide
Purity: ≥95%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 13870
Product name: Pyroxamide
Purity: ≥95%
Packaging: 25mg
Price: $250
Updated: 2024/03/01

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Pyroxamide Chemical Properties,Usage,Production

Description

Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC₅₀ = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.

Uses

Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.

Uses

Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

Definition

ChEBI: N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.

storage

-20°C

References

[1]. butler lm, webb y, agus db, et al. inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. clin cancer res, 2001, 7(4): 962-970.
[2]. kutko mc, glick rd, butler lm, et al. histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. clin cancer res, 2003, 9(15): 5749-5755.

Pyroxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pyroxamide manufacturers

Dideu Industries Group Limited

Product: Pyroxamide 382180-17-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

Career Henan Chemical Co

Product: Pyroxamide 382180-17-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-20

382180-17-8, PyroxamideRelated Search:

CHLOROPHOSPHONAZO III 2-HYDROXYACETAMIDE N-Methylformamide 3-Hydroxypyridine Polyacrylamide N,N-Dimethylformamide Pyroxamide

382180-17-8; NSC-696085; N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE; N-HYDROXY-N'-(PYRIDIN-3-YL)OCTANEDIAMIDE; NSC696085; NSC 696085

n-hydroxy-n'-(pyridin-3-yl)octanediamide

NSC 696085

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PyroxaMide (NSC 696085)

N1-Hydroxy-N8-3-pyridinyl-octanediamide

N1-Hydroxy-N8-(pyridin-3-yl)octanediamide

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N-Hydroxy-N'-3-pyridinyloctanediamide

Pyroxamide

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Pyroxamide ISO 9001：2015 REACH

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N-hydroxy-N'-(pyridin-3-yl)octanediamide

382180-17-8