6-Methoxy-1H-indazole

Product Name: 6-Methoxy-1H-indazole
CAS No.: 3522-07-4
Chemical Name: 6-Methoxy-1H-indazole
Synonyms: 6-methoxyindazole;6-Methoxy-1H-indazoL;6-Methyloxy-indazole;6-Methoxy-1H-indazole
CBNumber: CB0970673
Molecular Formula: C8H8N2O
Formula Weight: 148.16
MOL File: 3522-07-4.mol

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6-Methoxy-1H-indazole Property

Melting point:: 97-99 °C
Boiling point:: 312.5±15.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.29±0.40(Predicted)
Appearance: Off-white to yellow Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: J50206
Product name: 6-Methoxy-1H-indazole
Packaging: 5g
Price: $285
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H07-1-32
Product name: 6-Methoxy-1H-indazole
Packaging: 1g
Price: $345
Updated: 2021/12/16

Matrix Scientific

Product number: 068733
Product name: 6-Methoxyindazole
Purity: >95%
Packaging: 1g
Price: $415
Updated: 2021/12/16

AK Scientific

Product number: L862
Product name: 6-Methoxy-1H-indazole
Packaging: 5g
Price: $735
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0097245
Product name: 6-METHOXY-1H-INDAZOLE
Purity: 95.00%
Packaging: 1G
Price: $1492.26
Updated: 2021/12/16

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6-Methoxy-1H-indazole Chemical Properties,Usage,Production

Uses

6-Methoxy-1H-indazole is used as a raw material for organic synthesis or as a pharmaceutical intermediate compound. It can be used to prepare other heterocyclic compounds such as 1H-Indazol-6-ol, 6-Methoxy-1H-indazol-5-amine and 6-Methoxy-5-nitro-1H-indazole.

Synthesis

331-64-6

3522-07-4

The general procedure for the synthesis of 6-methoxy-1H-indazole from 2-fluoro-4-methoxybenzaldehyde is as follows: Preparation of intermediate 42: 2-fluoro-4-methoxybenzaldehyde (1 g, 6.5 mmol) was mixed with hydrazine (7 mL) and heated to reflux for 4 hours. After completion of the reaction, the reaction mixture was extracted with dichloromethane (3 x 75 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 6-methoxy-1H-indazole (Intermediate 42) (568 mg, 59% yield) as a yellow solid. Product characterization: HPLC purity 99%, retention time 2.159 min; mass spectrum (ESI) m/z 149.1 [M+H]+.

References

[1] Journal of Organic Chemistry, 2006, vol. 71, # 21, p. 8166 - 8172
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 8, p. 3076 - 3080
[3] Journal of Organic Chemistry, 2009, vol. 74, # 16, p. 6331 - 6334
[4] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 73
[5] Patent: CN108727267, 2018, A. Location in patent: Paragraph 0106; 0107; 0108

6-Methoxy-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Methoxy-1H-indazole Suppliers

China 118 Germany 1 India 2 United Kingdom 1 United States 14 Global 136

Pure Chemistry Scientific Inc.

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View Lastest Price from 6-Methoxy-1H-indazole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 6-Methoxy-1H-indazole 3522-07-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-25

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Methoxy-1H-indazole 3522-07-4
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-12

Career Henan Chemical Co

Product: 6-Methoxy-1H-indazole 3522-07-4
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

3522-07-4, 6-Methoxy-1H-indazoleRelated Search:

6-Methoxy-1H-indazole-3-carboxyaldehyde 1H-INDOLE-3-CARBONITRILE, 6-METHOXY- 6-METHOXYPYRIDINE-3-CARBOTHIOAMIDE 3-Iodo-5,6-dimethoxy-1H-indazole 3-IODO-6-METHOXY-1H-INDAZOLE METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE 5-Methoxy-1H-indazole-3-carboxylic acid ,97% 3-Cyano-5-methoxy-1H-indazole,5-METHOXY-1H-INDAZOLE-3-CARBONITRILE 5-Methoxy-1H-indazole ,97% 3-Cyano-6-methoxy-1H-indazole 6-METHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID 5-Methoxy-1H-indazole-3-carboxyaldehyde,5-METHOXY-1H-INDAZOLE-3-CARBALDEHYDE, 95+% 5,6-DIMETHOXY-1H-INDAZOLE 5,6-DIMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID 5,6-DIMETHOXY-1H-INDAZOLE-3-CARBONITRILE 6-BENZYLOXY-1H-INDAZOLE-3-CARBALDEHYDE METHYL 6-METHOXY-1H-INDAZOLE-3-CARBOXYLATE 6-BENZYLOXY-1H-INDAZOLE-3-CARBOXYLIC ACID

6-Methoxy-1H-indazole

6-methoxyindazole

6-Methyloxy-indazole

6-Methoxy-1H-indazoL

3522-07-4

5926-00-9

3522/7/4