2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-

Product Name: 2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-
CAS No.: 2561494-77-5
Chemical Name: 2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-
Synonyms: Inhibitor,UNC6934,Histone Methyltransferase,inhibit,UNC 6934,UNC-6934;N-Cyclopropyl-3-oxo-N-[4-(4-pyrimidinylcarbamoyl)benzyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide;2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-
CBNumber: CB09966192
Molecular Formula: C24H21N5O4
Formula Weight: 443.46
MOL File: 2561494-77-5.mol

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2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Property

Boiling point:: 697.2±55.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
pka: 10.91±0.70(Predicted)
form: solid
color: Pale yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Chemical Properties,Usage,Production

Description

UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2).? It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2.? UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases.? Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 μM).

storage

Store at -20°C

References

Dilworth et al. (2022), A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization; Nat. Chem. Biol., 18 56

2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Suppliers

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2561494-77-5, 2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-Related Search:

PF-01367338 RESINIFERATOXIN DO264 ML335

2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-

Inhibitor,UNC6934,Histone Methyltransferase,inhibit,UNC 6934,UNC-6934

N-Cyclopropyl-3-oxo-N-[4-(4-pyrimidinylcarbamoyl)benzyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide

2561494-77-5