Wee1 Antibody
Source Reactivity Background References- Product Name
- Wee1 Antibody
- Chemical Name
- Wee1 Antibody
- Synonyms
- Wee1 Antibody;Anti-WEE1 protein antibody
- CBNumber
- CB11003740
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb499671
- Product name
- WEE1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
Wee1 Antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Monkey
Background
Entry of all eukaryotic cells into mitosis is regulated by activation of cdc2 kinase. The critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Thr14. Phosphorylation at Tyr15 and Thr14 and inhibition of cdc2 is carried out by Wee1 and Myt1 protein kinases, while Tyr15 dephosphorylation and activation of cdc2 is carried out by the cdc25 phosphatase. Hyperphosphorylation and inactivation of Myt1 in mitosis suggests that one or more kinases activated at the G2/M transition negatively regulates Myt1 activity. Kinases shown to phosphorylate Myt1 include cdc2, p90RSK, Akt, and Plk1.Wee1 is inactivated upon mitotic entry by phosphorylation at Ser53 and Ser123 by Plk1 and cdc2, followed by beta-TrCP-mediated ubiquitination and degradation.
References
[1] Watanabe, N. et al. (1995) EMBO J. 14, 1878-1891.
[2] Hunter, T. (1995) Cell 80, 225-236.
[3] Galaktionov, K. et al. (1995) Genes Dev 9, 1046-58.
[4] McGowan, C.H. and Russell, P. (1993) EMBO J 12, 75-85.
[5] Booher, R.N. et al. (1997) J Biol Chem 272, 22300-6.
[6] Palmer, A. et al. (1998) EMBO J 17, 5037-5047.
[7] Nakajima, H. et al. (2003) J Biol Chem 278, 25277-80.
[8] Watanabe, N. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 4419-4424.
Wee1 Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
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