1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT

Product Name: 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
CAS No.: 168021-79-2
Chemical Name: 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
Synonyms: CPI22;D03875;HPN-07;CS-791;CPI 22;CPI-22;CXY059;OKN007;CXY 059;CXY-059
CBNumber: CB11009515
Molecular Formula: C11H14NNa2O7S2
Formula Weight: 382.3409
MOL File: 168021-79-2.mol

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1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Property

Melting point:: >300 °C
storage temp.: -20°C
solubility: Soluble in DMSO
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2163
Product name: HPN-07
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $64.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2163
Product name: HPN-07
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $264
Updated: 2024/03/01

Cayman Chemical

Product number: 22109
Product name: NXY-059
Purity: ≥98%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 22109
Product name: NXY-059
Purity: ≥98%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 22109
Product name: NXY-059
Purity: ≥98%
Packaging: 25mg
Price: $176
Updated: 2024/03/01

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1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Chemical Properties,Usage,Production

Uses

A free radical trapping compound

Uses

Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Used as a spin-trap agent. It is a clinically tested antioxidant and depicts potency against Ischemic stress, Neuroprotection.

Biological Activity

Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.

Biochem/physiol Actions

Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water).

References

[1] kuroda s1, tsuchidate r, smith ml, maples kr, siesjö bk.

1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Suppliers

Canada 1 China 74 France 1 India 1 United Kingdom 1 United States 16 Global 94

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168021-79-2, 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALTRelated Search:

1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT

disufenton sodium

Cerovive

D03875

Disufenton sodium (usan/inn)

NXY-059(Disufentonsodium)

Disufenton sodium (NXY-059)

4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisulfonicaciddisodiumsalt

Cerovive(NXY-059)

NXY-059(Cerovive)

Disufenton sodiuM (NXY 059,Cerovive)

NXY059/NXY-059

Disufenton

1,3-Benzenedisulfonic acid, 4-[[(1,1-dimethylethyl)imino]methyl]-, N-oxide, disodium salt

Disodium,4-[(Z)-[tert-butyl(oxido)azaniumylidene]methyl]benzene-1,3-disulfonate

HPN-07

NXY 059 (CEROVIVE);NXY059

CS-791

ARL-16556

CPI 22

CPI22

CPI-22

CXY 059

CXY059

CXY-059

NXY059; NXY 059; NXY-059; CXY 059; CXY059; CXY-059; OKN007; OKN-007; OKN 007; ARL 16556; ARL16556; ARL-16556; CPI-22; CPI22; CPI 22; CEROVIVE; DISUFENTON SODIUM

OKN 007

OKN007

OKN-007

ARL 16556

ARL16556

Disufenton sodium Cerovive NXY-059

Disufenton sodium,Inhibitor,Reactive Oxygen Species,inhibit,Disufenton

168021-79-2

C11H13NNa2O7S2

C11H14NNa2O7S2

Inhibitors