ChemicalBook > CAS DataBase List > ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE

ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE

Product Name
ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE
CAS No.
57626-37-6
Chemical Name
ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE
Synonyms
6-Methylimidazo[2,1-b][1,3]thiazole-5-carboxylate;Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate;ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE;6-methyl-5-imidazo[2,1-b]thiazolecarboxylic acid ethyl ester;Imidazo[2,1-b]thiazole-5-carboxylic acid, 6-methyl-, ethyl ester
CBNumber
CB11011244
Molecular Formula
C9H10N2O2S
Formula Weight
210.25
MOL File
57626-37-6.mol
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ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Property

Melting point:
98 °C
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.81±0.40(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E926405
Product name
Ethyl6-methylimidazo[2,1-b]thiazole-5-carboxylate
Packaging
100mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
W7100
Product name
Ethyl6-methylimidazo[2,1-b]thiazole-5-carboxylate
Packaging
250mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
069769
Product name
Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate
Purity
98%
Packaging
1g
Price
$605
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0029795
Product name
ETHYL 6-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$837.99
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0029795
Product name
ETHYL 6-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLATE
Purity
95.00%
Packaging
2.5G
Price
$1201.49
Updated
2021/12/16
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ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate

Synthesis

96-50-4

609-15-4

57626-37-6

The reaction was carried out with 2-aminothiazole (3.00 g, 29.99 mmol) and ethyl 2-chloroacetoacetate (4.96 mL, 35.99 mmol) in 1,2-dimethoxyethane (30 mL) at 90 °C for 6 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and diluted with ethyl acetate (80 mL), followed by washing the organic layer with water (3 x 30 mL). The organic layer was separated and dried with anhydrous sodium sulfate and concentrated in vacuum to obtain the crude product. The crude product was purified by column chromatography using 20% ethyl acetate/hexane as eluent to give ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate (2a) (5.20 g, 82% yield) as an off-white solid. The molecular weight of the product was confirmed to be 211 [M + H]+ by electrospray ionization mass spectrometry (ESIMS), followed by the next step of the reaction.

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 6, p. 1298 - 1307
[2] European Journal of Medicinal Chemistry, 1994, vol. 29, # 12, p. 981 - 983
[3] Patent: WO2010/90716, 2010, A1. Location in patent: Page/Page column 328
[4] Farmaco, Edizione Scientifica, 1983, vol. 38, # 7, p. 533 - 545
[5] Archiv der Pharmazie, 1976, vol. 309, # 12, p. 959 - 965

ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Suppliers

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57626-37-6, ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATERelated Search:

Ethyl 2-Methyl-Imidazo[2,1-B]Thiazole-3-Carboxylate ETHYL 6-(3-CHLOROPHENYL)IMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLATE ETHYL 6-THIOPHENOIMIDAZOLE-2-METHOXYMETHYL-3-CARBOXYLATE ETHYL 6-(2-CYCLOPENTYLETHYL)IMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLATE ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE IMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID, 6-(1-METHYLETHYL)-, ETHYL ESTER

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  • 6-methyl-5-imidazo[2,1-b]thiazolecarboxylic acid ethyl ester
  • Imidazo[2,1-b]thiazole-5-carboxylic acid, 6-methyl-, ethyl ester
  • 57626-37-6