ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE
- Product Name
- ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE
- CAS No.
- 57626-37-6
- Chemical Name
- ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE
- Synonyms
- 6-Methylimidazo[2,1-b][1,3]thiazole-5-carboxylate;Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate;ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE;6-methyl-5-imidazo[2,1-b]thiazolecarboxylic acid ethyl ester;Imidazo[2,1-b]thiazole-5-carboxylic acid, 6-methyl-, ethyl ester
- CBNumber
- CB11011244
- Molecular Formula
- C9H10N2O2S
- Formula Weight
- 210.25
- MOL File
- 57626-37-6.mol
ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Property
- Melting point:
- 98 °C
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.81±0.40(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E926405
- Product name
- Ethyl6-methylimidazo[2,1-b]thiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- W7100
- Product name
- Ethyl6-methylimidazo[2,1-b]thiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 069769
- Product name
- Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $605
- Updated
- 2021/12/16
- Product number
- CHM0029795
- Product name
- ETHYL 6-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $837.99
- Updated
- 2021/12/16
- Product number
- CHM0029795
- Product name
- ETHYL 6-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1201.49
- Updated
- 2021/12/16
ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Chemical Properties,Usage,Production
Uses
Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate
Synthesis
96-50-4
609-15-4
57626-37-6
The reaction was carried out with 2-aminothiazole (3.00 g, 29.99 mmol) and ethyl 2-chloroacetoacetate (4.96 mL, 35.99 mmol) in 1,2-dimethoxyethane (30 mL) at 90 °C for 6 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and diluted with ethyl acetate (80 mL), followed by washing the organic layer with water (3 x 30 mL). The organic layer was separated and dried with anhydrous sodium sulfate and concentrated in vacuum to obtain the crude product. The crude product was purified by column chromatography using 20% ethyl acetate/hexane as eluent to give ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate (2a) (5.20 g, 82% yield) as an off-white solid. The molecular weight of the product was confirmed to be 211 [M + H]+ by electrospray ionization mass spectrometry (ESIMS), followed by the next step of the reaction.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 6, p. 1298 - 1307
[2] European Journal of Medicinal Chemistry, 1994, vol. 29, # 12, p. 981 - 983
[3] Patent: WO2010/90716, 2010, A1. Location in patent: Page/Page column 328
[4] Farmaco, Edizione Scientifica, 1983, vol. 38, # 7, p. 533 - 545
[5] Archiv der Pharmazie, 1976, vol. 309, # 12, p. 959 - 965
ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 3-METHYL-IMIDAZO[2,1-B]THIAZOLE 4-CARBOXYLATE Suppliers
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