ChemicalBook > CAS DataBase List > Gepirone

Gepirone

Product Name: Gepirone
CAS No.: 83928-76-1
Chemical Name: Gepirone
Synonyms: GEPIRONE;Gepirona;Gepironum;Gepirone er;Gepirone HCl;Gepirone [inn];Gepironum [latin];Gepirona [spanish];ORG-13011(Gepirone);Gepirone(ORG-13011)
CBNumber: CB11011279
Molecular Formula: C19H29N5O2
Formula Weight: 359.47
MOL File: 83928-76-1.mol

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Gepirone Property

Melting point:: 106-108°C
Boiling point:: 562.3±60.0 °C(Predicted)
Density: 1.142±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 7.72±0.10(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1S/C19H29N5O2/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18/h5-7H,3-4,8-15H2,1-2H3
InChIKey: QOIGKGMMAGJZNZ-UHFFFAOYSA-N
SMILES: N1(CCCCN2CCN(C3=NC=CC=N3)CC2)C(=O)CC(C)(C)CC1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: G365000
Product name: Gepirone
Packaging: 250mg
Price: $845
Updated: 2021/12/16

Matrix Scientific

Product number: 099512
Product name: 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
Purity: 95%
Packaging: 250mg
Price: $925
Updated: 2021/12/16

AK Scientific

Product number: 2913AC
Product name: 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
Packaging: 1g
Price: $1023
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO65115
Product name: Gepirone
Packaging: 10mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO65115
Product name: Gepirone
Packaging: 50mg
Price: $225
Updated: 2021/12/16

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Gepirone Chemical Properties,Usage,Production

Description

Gepirone is a chemical analogue of buspirone and also acts as a partial agonist at 5-HT1A receptors. It is active in animal models predictive of anxiolytic action and also shows antidepressant activity in preclinical studies. With long-term administration, gepirone downregulates 5-HT2 receptors, which is a property common to nearly all antidepressant drugs (Stahl 1994). This dual action, suggesting both anxiolytic and antidepressant effects, is typical of many compounds acting at 5-HT1A receptors and may indicate that such compounds may be useful in the treatment of mixed anxiety and depression (Stahl, in press).
Preliminary phase II clinical data have shown that gepirone is an effective anxiolytic that significantly reduces both psychic and somatic symptoms of generalized anxiety disorder. Like buspirone, gepirone does not impair memory, verbal fluency, or psychomotor performance (Harto and Branconnier 1988).

Uses

Gepirone is an antidepressant and anxiolytic of the azapirone class. It acts as a selective partial agonist of the 5-HT1A receptor.

Definition

ChEBI: Gepirone is a N-arylpiperazine.

in vivo

Gepirone (0-3 mg/kg for intraperitoneal injection) interacts with progesterone at 5-HT_1A receptors to reduce lordosis behavior in female rats treated with estradiol benzoate and progesterone^[1].
Gepirone (10, 15 mg/kg for subcutaneous injection, 2, 7, or 14 days) activates the normosensitive postsynaptic 5-HT_1A receptor in Male Sprague-Dawley rats^[2].

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	0, 0.1, 0.3, 1 and 3 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Increases in lordotic activity at lower doses. Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.

Animal Model:	Male Sprague-Dawley rats^[2]
Dosage:	10, 15 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Decreased the number of spontaneously active 5-HT neurons and firing rate. Not modified with long-term treatment with ED₅₀ value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.

IC 50

5-HT_1A Receptor

Gepirone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Gepirone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: gepirone 83928-76-1
Price: US $8.80-2.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-27

83928-76-1, GepironeRelated Search:

Pipemidic acid Azaperone Buspirone hydrochloride Gepirone BUSPIRONE (D8) Buspirone 6-HYDROXY BUSPIRONE

GEPIRONE

4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione

4,4-Dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedione

2,6-Piperidinedione, 4,4-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-

83928-66-9 (Mono-hydrochloride)

Gepirona

Gepirona [spanish]

Gepirone [inn]

Gepirone er

Gepironum

Gepironum [latin]

ORG-13011(Gepirone)

Gepirone(ORG-13011)

Gepirone HCl

Gepirone, 10 mM in DMSO

83928-76-1

C19H29N5O2

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