ZILPATEROL HYDROCHLORIDE
- Product Name
- ZILPATEROL HYDROCHLORIDE
- CAS No.
- 119520-05-7
- Chemical Name
- ZILPATEROL HYDROCHLORIDE
- Synonyms
- zilpaterol Solution, 100ppm;zilpa;RU-4217;RU-42173;trans-(±)-Zilpaterol;Zilpaterol HCl and Enantiomer;ZIPATEROL HYDROCHLORIDE (FOR RESEARCH ONLY);ZILPATEROLHYDROCHLORIDEMONOHYDRATE(FORR&DONLY);(-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one;Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, trans-( -)-
- CBNumber
- CB11011688
- Molecular Formula
- C14H19N3O2
- Formula Weight
- 261.32
- MOL File
- 119520-05-7.mol
ZILPATEROL HYDROCHLORIDE Property
- Melting point:
- 123-126°C
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 13.39±0.60(Predicted)
- Stability:
- Temperature Sensitive
- CAS DataBase Reference
- 119520-05-7
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16484
- Product name
- Zilpaterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 16484
- Product name
- Zilpaterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 16484
- Product name
- Zilpaterol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- Z430000
- Product name
- Zilpaterol
- Packaging
- 2.5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- C3632
- Product name
- Zilpaterol
- Packaging
- 10mg
- Price
- $389
- Updated
- 2021/12/16
ZILPATEROL HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
Zilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues. It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle.
Uses
Zilpaterol is a β-Adrenergic agonist. Growth promotant.
Definition
ChEBI: Zilpaterol is a benzazepine.
Biological Activity
zilpaterol is a β-adrenergic receptor agonist.β-adrenergic receptors, prototypic g-protein-coupled receptors, play a key role in regulating numerous physiological processes.
in vitro
previus study found that there was no effect of zilpaterol (zh) on thymidine incorporation into dna. zh at 1 μm could decrease β1-ar mrna, and 0.01 and 1 μm zh decreased β2-ar and β3-ar mrna in myoblasts. there was no effect of zh on the β-ar or igf-i gene expression in fused myotube cultures. the β2-ar antagonist ici-118, 551 attenuated the effect of zh to reduce expression of β1- and β2-ar mrna. there was no effect of ici-118, 551 or zh on β3-ar or igf-i. in addition, the total lipid synthesis from acetate was increased by zh in bovine subcutaneous adipose tissue explants in the absence of theophylline [1].
in vivo
fda has approved label claims of increased rate of bw gain, improved feed efficiency, and increased carcass leanness. the feeding of zh for 20 to 40 d with a 3-d withdrawal resulted in significantly increased adg. such increases equate to an average of 9 kg heavier bw in zh-fed steers. moreover, hot carcass weight has been shown to increase to a larger degree compared with bw, with an average improvement of 15 kg [2].
References
[1] miller, e. k.,chung, k.y.,hutcheson, j.p., et al. zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. journal of animal science 90(4), 1317-1327 (2012).
[2] delmore, r. j.,hodgen, j.m. and johnson, b.j. perspectives on the application of zilpaterol hydrochloride in the united states beef industry. journal of animal science 88(8), 2825-2828 (2010).
ZILPATEROL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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