ZILPATEROL HYDROCHLORIDE

Product Name: ZILPATEROL HYDROCHLORIDE
CAS No.: 119520-05-7
Chemical Name: ZILPATEROL HYDROCHLORIDE
Synonyms: zilpaterol Solution, 100ppm;zilpa;RU-4217;RU-42173;trans-(±)-Zilpaterol;Zilpaterol HCl and Enantiomer;ZIPATEROL HYDROCHLORIDE (FOR RESEARCH ONLY);ZILPATEROLHYDROCHLORIDEMONOHYDRATE(FORR&DONLY);(-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one;Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, trans-( -)-
CBNumber: CB11011688
Molecular Formula: C14H19N3O2
Formula Weight: 261.32
MOL File: 119520-05-7.mol

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ZILPATEROL HYDROCHLORIDE Property

Melting point:: 123-126°C
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide
form: crystalline solid
pka: 13.39±0.60(Predicted)
Stability:: Temperature Sensitive
CAS DataBase Reference: 119520-05-7

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16484
Product name: Zilpaterol
Purity: ≥98%
Packaging: 1mg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 16484
Product name: Zilpaterol
Purity: ≥98%
Packaging: 5mg
Price: $149
Updated: 2021/12/16

Cayman Chemical

Product number: 16484
Product name: Zilpaterol
Purity: ≥98%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

TRC

Product number: Z430000
Product name: Zilpaterol
Packaging: 2.5mg
Price: $100
Updated: 2021/12/16

ApexBio Technology

Product number: C3632
Product name: Zilpaterol
Packaging: 10mg
Price: $389
Updated: 2021/12/16

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ZILPATEROL HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Zilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues. It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle.

Uses

Zilpaterol is a β-Adrenergic agonist. Growth promotant.

Definition

ChEBI: Zilpaterol is a benzazepine.

Biological Activity

zilpaterol is a β-adrenergic receptor agonist.β-adrenergic receptors, prototypic g-protein-coupled receptors, play a key role in regulating numerous physiological processes.

in vitro

previus study found that there was no effect of zilpaterol (zh) on thymidine incorporation into dna. zh at 1 μm could decrease β1-ar mrna, and 0.01 and 1 μm zh decreased β2-ar and β3-ar mrna in myoblasts. there was no effect of zh on the β-ar or igf-i gene expression in fused myotube cultures. the β2-ar antagonist ici-118, 551 attenuated the effect of zh to reduce expression of β1- and β2-ar mrna. there was no effect of ici-118, 551 or zh on β3-ar or igf-i. in addition, the total lipid synthesis from acetate was increased by zh in bovine subcutaneous adipose tissue explants in the absence of theophylline [1].

in vivo

fda has approved label claims of increased rate of bw gain, improved feed efficiency, and increased carcass leanness. the feeding of zh for 20 to 40 d with a 3-d withdrawal resulted in significantly increased adg. such increases equate to an average of 9 kg heavier bw in zh-fed steers. moreover, hot carcass weight has been shown to increase to a larger degree compared with bw, with an average improvement of 15 kg [2].

References

[1] miller, e. k.,chung, k.y.,hutcheson, j.p., et al. zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. journal of animal science 90(4), 1317-1327 (2012).
[2] delmore, r. j.,hodgen, j.m. and johnson, b.j. perspectives on the application of zilpaterol hydrochloride in the united states beef industry. journal of animal science 88(8), 2825-2828 (2010).

ZILPATEROL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ZILPATEROL HYDROCHLORIDE Suppliers

Canada 1 China 25 Germany 1 India 3 United Kingdom 2 United States 10 Global 42

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119520-05-7, ZILPATEROL HYDROCHLORIDERelated Search:

Zilpaterol-d7 1H-1-BENZAZEPIN-5-OL, 2,3,4,5-TETRAHYDRO- 4-METHYLBENZIMIDAZOLONE Zileuton ZILPATEROL HYDROCHLORIDE

ZIPATEROL HYDROCHLORIDE (FOR RESEARCH ONLY)

(-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one

RU-4217

zilpa

ZILPATEROLHYDROCHLORIDEMONOHYDRATE(FORR&DONLY)

RU-42173

Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, (6R,7R)-rel-

Imidazo(4,5,1-jk)(1)benzazepin-2(1H)-one, 4,5,6,7-tetrahydro-7-hydroxy-6-((1-methylethyl)amino)-, trans-( -)-

zilpaterol Solution, 100ppm

trans-(±)-Zilpaterol

Zilpaterol HCl and Enantiomer

119520-05-7

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