4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 50920-64-4
- Chemical Name
- 4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 2-ethyl-5-methylpyrazole-3-carboxylate;Ethyl 1-ethyl-3-methylpyrazole-5-carboxylate;1H-Pyrazole-5-carboxylic acid, 1-ethyl-3-methyl-, ethyl ester
- CBNumber
- CB11013147
- Molecular Formula
- C9H14N2O2
- Formula Weight
- 182.22
- MOL File
- 50920-64-4.mol
4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y5456
- Product name
- Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
- Packaging
- 5g
- Price
- $531
- Updated
- 2021/12/16
- Product number
- Y5456
- Product name
- Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
- Packaging
- 10g
- Price
- $798
- Updated
- 2021/12/16
- Product number
- CD11113821
- Product name
- Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $554
- Updated
- 2021/12/16
- Product number
- A219504
- Product name
- Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- A219504
- Product name
- Ethyl1-ethyl-3-methyl-1H-pyrazole-5-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $118
- Updated
- 2021/12/16
4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
50920-65-5
64-17-5
50920-64-4
Oxalyl chloride (5.68 mL, 64.9 mmol) was slowly added dropwise to a suspension of 1-ethyl-3-methyl-1H-pyrazole-5-carboxylic acid (5 g, 32.4 mmol) dissolved in dichloromethane (40 mL) at room temperature and two drops of N,N-dimethylformamide (DMF) were added as catalyst. The reaction mixture was stirred at room temperature for 2 h, subsequently concentrated by rotary evaporator and dried under vacuum. Anhydrous ethanol (50 mL, 856 mmol) was added to the resulting residue and the reaction mixture continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was again concentrated by rotary evaporator and dried under vacuum. The light yellow oil obtained was dissolved in ethyl acetate (100 mL), washed sequentially with saturated sodium bicarbonate solution and brine, and the organic phase was dried with anhydrous sodium sulfate, filtered, and concentrated. Finally, the residue was dried under vacuum to give ethyl 3-methyl-1-ethyl-1H-pyrazole-5-carboxylate (5.5 g, 30.2 mmol, 93% yield) as a light yellow oil. The product was characterized by 1H NMR (400 MHz, chloroform-d) and LCMS (LCMS method E): 1H NMR δ 6.63 (s, 1H), 4.56 (q, J = 7.11 Hz, 2H), 4.35 (q, J = 7.11 Hz, 2H), 2.30 (s, 3H), 1.44 (t, J = 7.28 Hz, 3H), 1.39 (t, J = 7.28 Hz, 3H); LCMS Rt = 0.81 min, [M + H]+ = 183.1.
References
[1] Patent: WO2017/175147, 2017, A1. Location in patent: Page/Page column 191
4-BROMO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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