SULCONAZOLE
- Product Name
- SULCONAZOLE
- CAS No.
- 61318-90-9
- Chemical Name
- SULCONAZOLE
- Synonyms
- Sulconazol;SULCONAZOLE;SULCONAZOLE USP/EP/BP;Sulconazle Impurity 3;1-(2-((4-Chlorobenzyl);-2-(2,4-dichlorophenyl);Uniconazole sulfur nitrate;Quizalofop Impurity 8(Propaquizafop);Sulconazole (base and/or unspecified salts);1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-iMidazole
- CBNumber
- CB1102530
- Molecular Formula
- C18H15Cl3N2S
- Formula Weight
- 397.75
- MOL File
- 61318-90-9.mol
SULCONAZOLE Property
- Boiling point:
- 558.2±50.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.55±0.12(Predicted)
- CAS DataBase Reference
- 61318-90-9
N-Bromosuccinimide Price
- Product number
- API0004256
- Product name
- SULCONAZOLE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $885.31
- Updated
- 2021/12/16
- Product number
- API0004256
- Product name
- SULCONAZOLE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1091.48
- Updated
- 2021/12/16
- Product number
- API0004256
- Product name
- SULCONAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1575
- Updated
- 2021/12/16
- Product number
- MT-58832
- Product name
- Sulconazole
- Purity
- 98%
- Packaging
- 0.5g
- Price
- $380
- Updated
- 2021/12/16
- Product number
- 61318909
- Product name
- 1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
- Packaging
- 1g
- Price
- $653.12
- Updated
- 2021/12/16
SULCONAZOLE Chemical Properties,Usage,Production
Uses
Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.
Indications
Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts.
Definition
ChEBI: A member of the class of imidazoles that is 1-ethyl-1H-imidazole in which one of the hydrogens of the methyl group is replaced by a (4-chlorobenzyl)sulfanediyl group while a second is replaced by a 2,4-dichlorophenyl group.
Side effects
Local irritations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
Synthesis
Sulconazole, 1-[2,4-dichloro-|?-[(4-chlorobenzyl)thio]phenethyl]-imidazole (35.2.9), is an analog of exonazole. It differs in the replacement of the etheral oxygen bridge (which connects the 4-chlorobenzyl part of the molecule with phenethylimidazole) for a thioether bond. The corresponding changes in the synthesis of this drug are the replacement of the hydroxyl group in 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)-ethanol (35.2.6) with a chlorine atom using thionyl chloride, followed by a reaction of the resulting chloride with 4-chlorobenzylmercaptane to make sulconazole.
Solubility in organics
1 part in 3,333 (water), 1 part in 100 (ethanol), 1 part in 130 (acetone), 1 part in 333 (chloroform), 1 part in 2000 (dioxan), 1 part in 71 (methanol), 1 part in 286(chloromethane), 1 part in 10 (pyridine), 1 part in 2000 (toluene).
SULCONAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SULCONAZOLE manufacturers
- Product
- Sulconazole 61318-90-9
- Price
- US $0.01-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2020-05-11
- Product
- SULCONAZOLE 61318-90-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-16