6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine
- Product Name
- 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine
- CAS No.
- 167355-41-1
- Chemical Name
- 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine
- Synonyms
- 101397;6-bromo-1,2,3,4-tetrahydro-2-Naphthalenamine;6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine;2-Amino-6-bromo-1,2,3,4-tetrahydronaphthalene;6-Bromo-1,2,3,4-tetrahydro-phthalen-2-ylamine;2-Naphthalenamine, 6-bromo-1,2,3,4-tetrahydro-;6-BROMO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE;6-BROMO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE
- CBNumber
- CB1103355
- Molecular Formula
- C10H12BrN
- Formula Weight
- 226.11
- MOL File
- 167355-41-1.mol
6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine Property
- Boiling point:
- 298.7±40.0 °C(Predicted)
- Density
- 1.413±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 10.02±0.20(Predicted)
Safety
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8535AA
- Product name
- 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- HCH0049803
- Product name
- 2-AMINO-6-BROMO-1,2,3,4-TETRAHYDRONAPHTHALENE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1331.6
- Updated
- 2021/12/16
- Product number
- HCH0049803
- Product name
- 2-AMINO-6-BROMO-1,2,3,4-TETRAHYDRONAPHTHALENE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $3038.7
- Updated
- 2021/12/16
- Product number
- CD12135092
- Product name
- 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $1865
- Updated
- 2021/12/16
- Product number
- 167355411
- Product name
- 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine
- Packaging
- 5g
- Price
- $2068
- Updated
- 2021/12/16
6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine Chemical Properties,Usage,Production
Synthesis
4133-35-1
167355-41-1
General procedure: preparation of 6-bromo-1,2,3,4-tetrahydronaphthalen-2-amine. To a solution of methanol (100 mL) containing 6-bromo-3,4-dihydro-1H-2-naphthalenone (2 g, 8.89 mmol) and NH4OAc (5.52 g, 71.61 mmol), NaCNBH3 (0.67 g, 10.66 mmol) was added at room temperature. The reaction mixture was stirred at room temperature for 20 h. The solution was observed to turn yellow. After completion of the reaction, the reaction mixture was acidified with 2M HCl and stirred for 10 min, followed by evaporation to remove methanol. The mixture was extracted twice with dichloromethane (CH2Cl2). The aqueous layer was adjusted to pH 10 with 1.0 N NaOH and again extracted twice with dichloromethane (CH2Cl2). The organic layers were combined, dried over anhydrous MgSO4 and concentrated in vacuum to afford 1.31 g (65% yield) of the target product 6-bromo-1,2,3,4-tetrahydronaphthalen-2-amine as a yellow oil, which could be used in the subsequent reaction without further purification.LRMS: m/z 226.1 (M + H)+, 209 (M + H-NH3)+. Retention time: 3.84 min (Method B). 1H NMR (300 MHz, CD3OD) δ 7.27-7.35 (m, 8H), 7.05 (d, J = 8.4Hz, 4H), 3.56 (m, 1H), 3.17 (dd, J = 3.9,16.2Hz, 1H), 2.95 (m, 2H), 2.81 (dd, J = 9.9,16.2Hz, 1H), 2.19-2.29 (m, 1H), 1.79-1.92 (m, 1H).
References
[1] Patent: EP2202232, 2010, A1. Location in patent: Page/Page column 71
[2] Patent: WO2016/16162, 2016, A1. Location in patent: Page/Page column 21
[3] Patent: WO2016/33025, 2016, A1. Location in patent: Page/Page column 62-63
[4] Patent: WO2008/1160, 2008, A1. Location in patent: Page/Page column 21-23
[5] Patent: US2005/75324, 2005, A1. Location in patent: Page/Page column 9; 10
6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine manufacturers
- Product
- 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine 167355-41-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02