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Ambroxol

Product Name
Ambroxol
CAS No.
18683-91-5
Chemical Name
Ambroxol
Synonyms
ambroxol base;Pect;NA-872;Motosol;Mucofar;Mucosan;Ambroxo;AMBROXOL;Fluibron;Lindoxyl
CBNumber
CB9186114
Molecular Formula
C13H18Br2N2O
Formula Weight
378.1
MOL File
18683-91-5.mol
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Ambroxol Property

Melting point:
233-234 C
Boiling point:
468.6±45.0 °C(Predicted)
Density 
1.5863 (rough estimate)
refractive index 
1.6220 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Soluble in Water.
form 
solid
pka
15.12±0.40(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference
18683-91-5(CAS DataBase Reference)
NIST Chemistry Reference
Ambroxol(18683-91-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26
WGK Germany 
3
RTECS 
GV8423000
Toxicity
guinea pig,LD50,intraperitoneal,280mg/kg (280mg/kg),Medicamentos de Actualidad. Vol. 15, Pg. 523, 1979.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19377
Product name
Ambroxol
Purity
≥98%
Packaging
25mg
Price
$29
Updated
2021/12/16
Cayman Chemical
Product number
19377
Product name
Ambroxol
Purity
≥98%
Packaging
50mg
Price
$49
Updated
2021/12/16
Cayman Chemical
Product number
19377
Product name
Ambroxol
Purity
≥98%
Packaging
100mg
Price
$93
Updated
2021/12/16
TRC
Product number
A575990
Product name
Ambroxol
Packaging
50mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA64052
Product name
Ambroxol
Packaging
2g
Price
$150
Updated
2021/12/16
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Ambroxol Chemical Properties,Usage,Production

Description

Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in rat), and inhibits the release of inflammatory mediators from human leukocytes and mast cells (effective dose ~ 100 μM)

Originator

Mucosolvan,Thomae,W. Germany,1980

Uses

Ambroxol is a metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug. Free base of Ambroxol Hydrochloride (A575900).

Uses

expectorant

Definition

ChEBI: Ambroxol is an aromatic amine.

Manufacturing Process

6.5 g of N-(trans-p-hydroxycyclohexyl)-(2-aminobenzyl)-amine were dissolved in a mixture of 80 cc of glacial acetic acid and 20 cc of water, and then 9.6 g of bromine were added dropwise at room temperature while stirring the solution. After all of the bromine had been added, the reaction mixture was stirred for two hours more and was then concentrated in a water aspirator vacuum. The residue was taken up in 2 N ammonia, the solution was extracted several times with chloroform, and the organic extract solutions were combined and evaporated. The residue, raw N-(trans-phydroxycyclohexyl)-( 2-amino-3,5-dibromobenzyl)-amine, was purified with chloroform and ethyl acetate over silica gel in a chromatographic column, the purified product was dissolved in a mixture of ethanol and ether, and the solution was acidified with concentrated hydrochloric acid. The precipitate formed thereby was collected and recrystallized from ethanol and ether, yielding N-(trans-p-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine hydrochloride, MP 233-234.5°C (decomposition).

Therapeutic Function

Expectorant

References

1) Teramoto et al. (1999), Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary diseases; Pharmacology, 59 135 2) Nowak et al. (1995), Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice; Free Radic. Biol. Med., 19 659 3) Gibbs et al. (1999), Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells; Inflamm. Res., 48 86

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Ambroxol Suppliers

JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17839
Advantage
64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
4000505016; 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5000
Advantage
50
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4505
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
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View Lastest Price from Ambroxol manufacturers

Hebei Dangtong Import and export Co LTD
Product
Ambroxol 18683-91-5
Price
US $9.00-7.00/kilograms
Min. Order
10kilograms
Purity
99%
Supply Ability
100tons
Release date
2023-02-16
Hebei Duling International Trade Co. LTD
Product
Ambroxol 18683-91-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-03-22
Shanghai Chinqesen Biotechnology Co., Ltd.
Product
Ambroxol 18683-91-5
Price
US $40.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000000
Release date
2023-10-31

18683-91-5, AmbroxolRelated Search:


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