4-Fluorobenzylamine
- Product Name
- 4-Fluorobenzylamine
- CAS No.
- 140-75-0
- Chemical Name
- 4-Fluorobenzylamine
- Synonyms
- (4-Fluorophenyl)methanamine;P-FLUOROBENZYLAMINE;Benzylamine, p-fluoro-;NSC 158269;AURORA KA-7685;P-flubenzylamine;AKOS BBS-00003618;RARECHEM AL BW 0026;4-FLUOROBENZYLAMINE;4-fluro benzylamine
- CBNumber
- CB5716902
- Molecular Formula
- C7H8FN
- Formula Weight
- 125.14
- MOL File
- 140-75-0.mol
4-Fluorobenzylamine Property
- Melting point:
- 183 °C
- Boiling point:
- 183 °C (lit.)
- Density
- 1.095 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.512(lit.)
- Flash point:
- 152 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 9.01±0.10(Predicted)
- form
- Liquid
- Specific Gravity
- 1.101.095
- color
- Clear colorless to light yellow
- Water Solubility
- Soluble in water.
- Sensitive
- Air Sensitive
- BRN
- 636501
- InChIKey
- IIFVWLUQBAIPMJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 140-75-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenemethanamine, 4-fluoro-(140-75-0)
- EPA Substance Registry System
- Benzenemethanamine, 4-fluoro- (140-75-0)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-20/21/22
- Safety Statements
- 26-27-36/37/39-45-36/39
- RIDADR
- UN 2735 8/PG 2
- WGK Germany
- 3
- F
- 10-34
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29214980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P234Keep only in original container.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 162493
- Product name
- 4-Fluorobenzylamine
- Purity
- 97%
- Packaging
- 5g
- Price
- $36.4
- Updated
- 2024/03/01
- Product number
- 162493
- Product name
- 4-Fluorobenzylamine
- Purity
- 97%
- Packaging
- 25g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- F0252
- Product name
- 4-Fluorobenzylamine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $38
- Updated
- 2024/03/01
- Product number
- F0252
- Product name
- 4-Fluorobenzylamine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $56
- Updated
- 2024/03/01
- Product number
- A15486
- Product name
- 4-Fluorobenzylamine, 98+%
- Packaging
- 10g
- Price
- $31.65
- Updated
- 2024/03/01
4-Fluorobenzylamine Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liquid.
Uses
4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds.
General Description
[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds.
Synthesis
In a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%.
4-Fluorobenzylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluorobenzylamine manufacturers
- Product
- 4-Fluorobenzylamine 140-75-0
- Price
- US $10.00-150.00/kg
- Min. Order
- 1kg
- Purity
- NLT98%
- Supply Ability
- 2 ton per month
- Release date
- 2023-04-02
- Product
- 4-Fluorobenzylamine 140-75-0
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-16
- Product
- 4-Fluorobenzylamine 140-75-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-09-09