ChemicalBook > CAS DataBase List > 4-Fluorobenzylamine

4-Fluorobenzylamine

Product Name
4-Fluorobenzylamine
CAS No.
140-75-0
Chemical Name
4-Fluorobenzylamine
Synonyms
(4-Fluorophenyl)methanamine;P-FLUOROBENZYLAMINE;Benzylamine, p-fluoro-;NSC 158269;AURORA KA-7685;P-flubenzylamine;AKOS BBS-00003618;RARECHEM AL BW 0026;4-FLUOROBENZYLAMINE;4-fluro benzylamine
CBNumber
CB5716902
Molecular Formula
C7H8FN
Formula Weight
125.14
MOL File
140-75-0.mol
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4-Fluorobenzylamine Property

Melting point:
183 °C
Boiling point:
183 °C (lit.)
Density 
1.095 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.512(lit.)
Flash point:
152 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
pka
9.01±0.10(Predicted)
form 
Liquid
Specific Gravity
1.101.095
color 
Clear colorless to light yellow
Water Solubility 
Soluble in water.
Sensitive 
Air Sensitive
BRN 
636501
InChIKey
IIFVWLUQBAIPMJ-UHFFFAOYSA-N
CAS DataBase Reference
140-75-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzenemethanamine, 4-fluoro-(140-75-0)
EPA Substance Registry System
Benzenemethanamine, 4-fluoro- (140-75-0)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-20/21/22
Safety Statements 
26-27-36/37/39-45-36/39
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
10-34
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29214980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
162493
Product name
4-Fluorobenzylamine
Purity
97%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
162493
Product name
4-Fluorobenzylamine
Purity
97%
Packaging
25g
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
F0252
Product name
4-Fluorobenzylamine
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
F0252
Product name
4-Fluorobenzylamine
Purity
>98.0%(GC)
Packaging
25g
Price
$56
Updated
2024/03/01
Alfa Aesar
Product number
A15486
Product name
4-Fluorobenzylamine, 98+%
Packaging
10g
Price
$31.65
Updated
2024/03/01
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4-Fluorobenzylamine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid.

Uses

4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds.

General Description

[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds.

Synthesis

In a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%.

4-Fluorobenzylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluorobenzylamine Suppliers

Taizhou Chuangyuan Industrial Technology Co. Ltd.
Tel
13757609826
Email
sales@tzchemical.com
Country
China
ProdList
217
Advantage
58
Shanghai Taijilin Industrial Co., Ltd.
Tel
021-021-50630626 18964684208
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1230
Advantage
58
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375878 15269101859
Email
2710825968@qq.com
Country
China
ProdList
303
Advantage
58
Nanjing Dilu Pharmaceutical Co., Ltd
Tel
18014482516
Email
977144864@qq.com
Country
China
ProdList
402
Advantage
58
Nanjing Jubai Biomedical Technology Co., Ltd.
Tel
13585203734
Email
235694118@qq.com
Country
China
ProdList
404
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from 4-Fluorobenzylamine manufacturers

Anhui Dexinjia Biopharm Co., Ltd
Product
4-Fluorobenzylamine 140-75-0
Price
US $10.00-150.00/kg
Min. Order
1kg
Purity
NLT98%
Supply Ability
2 ton per month
Release date
2023-04-02
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Fluorobenzylamine 140-75-0
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-16
Hebei Mojin Biotechnology Co.,Ltd
Product
4-Fluorobenzylamine 140-75-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-09

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