Ambroxol

ChemicalBook > CAS DataBase List > Ambroxol

Product Name: Ambroxol
CAS No.: 18683-91-5
Chemical Name: Ambroxol
Synonyms: ambroxol base;Pect;NA-872;Motosol;Mucofar;Mucosan;Ambroxo;AMBROXOL;Fluibron;Lindoxyl
CBNumber: CB9186114
Molecular Formula: C13H18Br2N2O
Formula Weight: 378.1
MOL File: 18683-91-5.mol

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Ambroxol Property

Melting point:: 233-234 C
Boiling point:: 468.6±45.0 °C(Predicted)
Density: 1.5863 (rough estimate)
refractive index: 1.6220 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Soluble in Water.
form: solid
pka: 15.12±0.40(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference: 18683-91-5(CAS DataBase Reference)
NIST Chemistry Reference: Ambroxol(18683-91-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 36-26
WGK Germany: 3
RTECS: GV8423000
Toxicity: guinea pig,LD50,intraperitoneal,280mg/kg (280mg/kg),Medicamentos de Actualidad. Vol. 15, Pg. 523, 1979.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19377
Product name: Ambroxol
Purity: ≥98%
Packaging: 25mg
Price: $29
Updated: 2021/12/16

Cayman Chemical

Product number: 19377
Product name: Ambroxol
Purity: ≥98%
Packaging: 50mg
Price: $49
Updated: 2021/12/16

Cayman Chemical

Product number: 19377
Product name: Ambroxol
Purity: ≥98%
Packaging: 100mg
Price: $93
Updated: 2021/12/16

TRC

Product number: A575990
Product name: Ambroxol
Packaging: 50mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 099449
Product name: trans-4-((2-Amino-3,5-dibromobenzyl)-amino)cyclohexanol hydrochloride
Purity: 95+%
Packaging: 250mg
Price: $13
Updated: 2021/12/16

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Ambroxol Chemical Properties,Usage,Production

Description

Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in rat), and inhibits the release of inflammatory mediators from human leukocytes and mast cells (effective dose ~ 100 μM)

Originator

Mucosolvan,Thomae,W. Germany,1980

Uses

Ambroxol is a metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug. Free base of Ambroxol Hydrochloride (A575900).

Uses

expectorant

Definition

ChEBI: Ambroxol is an aromatic amine.

Manufacturing Process

6.5 g of N-(trans-p-hydroxycyclohexyl)-(2-aminobenzyl)-amine were dissolved in a mixture of 80 cc of glacial acetic acid and 20 cc of water, and then 9.6 g of bromine were added dropwise at room temperature while stirring the solution. After all of the bromine had been added, the reaction mixture was stirred for two hours more and was then concentrated in a water aspirator vacuum. The residue was taken up in 2 N ammonia, the solution was extracted several times with chloroform, and the organic extract solutions were combined and evaporated. The residue, raw N-(trans-phydroxycyclohexyl)-( 2-amino-3,5-dibromobenzyl)-amine, was purified with chloroform and ethyl acetate over silica gel in a chromatographic column, the purified product was dissolved in a mixture of ethanol and ether, and the solution was acidified with concentrated hydrochloric acid. The precipitate formed thereby was collected and recrystallized from ethanol and ether, yielding N-(trans-p-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine hydrochloride, MP 233-234.5°C (decomposition).

Therapeutic Function

Expectorant

References

1) Teramoto et al. (1999), Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary diseases; Pharmacology, 59 135 2) Nowak et al. (1995), Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice; Free Radic. Biol. Med., 19 659 3) Gibbs et al. (1999), Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells; Inflamm. Res., 48 86

Ambroxol Preparation Products And Raw materials

Raw materials

Methyl anthranilate trans-4-Aminocyclohexanol hydrochloride Octanoic hydrazide Sodium sulfate Ambroxol hydrochloride 2-Methoxyethanol METHANESULFONYL HYDRAZIDE Dibromo Sulfurous Acid Methanesulfonyl chloride 1,4-Dioxane Concentrated sulfuric acid Lithium Aluminum Hydride Tetrachloroethylene Acetic acid Bromide 1,4-Dibromobenzene

Preparation Products

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View Lastest Price from Ambroxol manufacturers

Hebei Dangtong Import and export Co LTD

Product: Ambroxol 18683-91-5
Price: US $9.00-7.00/kilograms
Min. Order: 10kilograms
Purity: 99%
Supply Ability: 100tons
Release date: 2023-02-16

Shanghai Chinqesen Biotechnology Co., Ltd.

Product: Ambroxol 18683-91-5
Price: US $40.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000000
Release date: 2023-10-31

Henan Bao Enluo International TradeCo.，LTD

Product: Ambroxol 18683-91-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000tons
Release date: 2023-07-10

18683-91-5, AmbroxolRelated Search:

Cyclamic acid trans,trans-2,4-Undecadienal Molasses ALTRENOGEST 4-Hydroxybenzylamine Phenoxybenzamine hydrochloride Trimethoprim Glycine 4-Fluorobenzylamine 6-Aminocaproic acid AMBROXOL HCL Ambroxol HCL and Sodium Chloride Injection Trans-4-Aminocyclohexanol ( For Ambroxol Hcl ) Bromine Cyclohexylamine 2-AMINO-3,5-DIBROMOBENZYL ALCOHOL Neltenexine RAC TRANS AMBROXOL-D5

4-((2-amino-3,5-dibromobenzyl)amino)-(e)-cyclohexano

5-dibromophenyl)methyl)amino)-4-(((2-amino-trans-cyclohexano

Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)- (E)-

Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, trans-

n-(2-amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol

n-(2-amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol

N-(trans-4-Hidroxiciclohexil)-(2-amino-3,5-dibromobencil)amina

N-(trans-4-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine

N-(trans-p-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)amine

NA-872

trans-4-((2-Amino-3,5-dibromobencil)amino)ciclohexanol

4-[(2-azanyl-3,5-dibromo-phenyl)methylamino]cyclohexan-1-ol

trans-4-((2-amino-3,5-dibromobenzyl)amine)cyclohexanol

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol

2-amino-3,5-dibromo-n-(trans-4-hydroxycyclohexyl)benzylamine

AMBROXOL

ambroxol base

4-(2-AMINO-3,5-DIBROMO-BENZYLAMINO)-CYCLOHEXANOL

Bronchopmnt

Duramu．Cat

Fluibron

Lindoxyl

Motosol

Mucofar

Mucosan

Pect

Solvolan

Sufactal

Surbronc

(1α,4β)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol

trans-N-[2-Amino-3,5-dibromobenzyl]-4-hydroxycyclohexylamine

4-[[(2-Amino-3，5-dibromophenyl)methyl]amino]cyclohexanol

Ambroxolum

Ambroxol USP/EP/BP

AmbroxolQ: What is Ambroxol Q: What is the CAS Number of Ambroxol Q: What is the storage condition of Ambroxol Q: What are the applications of Ambroxol

4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexano1-ol

Ambroxo

AMBROXOL 60.0% PELLETS

18683-91-5

23858-92-4

C13H19Br2ClN2O

C13H18Br2N2O

C13H18Br2N2OxHCl

Analytical Standards

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