Ambroxol
- Product Name
- Ambroxol
- CAS No.
- 18683-91-5
- Chemical Name
- Ambroxol
- Synonyms
- ambroxol base;Pect;NA-872;Motosol;Mucofar;Mucosan;Ambroxo;AMBROXOL;Fluibron;Lindoxyl
- CBNumber
- CB9186114
- Molecular Formula
- C13H18Br2N2O
- Formula Weight
- 378.1
- MOL File
- 18683-91-5.mol
Ambroxol Property
- Melting point:
- 233-234 C
- Boiling point:
- 468.6±45.0 °C(Predicted)
- Density
- 1.5863 (rough estimate)
- refractive index
- 1.6220 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Soluble in Water.
- form
- solid
- pka
- 15.12±0.40(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 18683-91-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Ambroxol(18683-91-5)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36-26
- WGK Germany
- 3
- RTECS
- GV8423000
- Toxicity
- guinea pig,LD50,intraperitoneal,280mg/kg (280mg/kg),Medicamentos de Actualidad. Vol. 15, Pg. 523, 1979.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19377
- Product name
- Ambroxol
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 19377
- Product name
- Ambroxol
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 19377
- Product name
- Ambroxol
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $93
- Updated
- 2021/12/16
- Product number
- A575990
- Product name
- Ambroxol
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FA64052
- Product name
- Ambroxol
- Packaging
- 2g
- Price
- $150
- Updated
- 2021/12/16
Ambroxol Chemical Properties,Usage,Production
Description
Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in rat), and inhibits the release of inflammatory mediators from human leukocytes and mast cells (effective dose ~ 100 μM)
Originator
Mucosolvan,Thomae,W. Germany,1980
Uses
Ambroxol is a metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug. Free base of Ambroxol Hydrochloride (A575900).
Uses
expectorant
Definition
ChEBI: Ambroxol is an aromatic amine.
Manufacturing Process
6.5 g of N-(trans-p-hydroxycyclohexyl)-(2-aminobenzyl)-amine were dissolved in a mixture of 80 cc of glacial acetic acid and 20 cc of water, and then 9.6 g of bromine were added dropwise at room temperature while stirring the solution. After all of the bromine had been added, the reaction mixture was stirred for two hours more and was then concentrated in a water aspirator vacuum. The residue was taken up in 2 N ammonia, the solution was extracted several times with chloroform, and the organic extract solutions were combined and evaporated. The residue, raw N-(trans-phydroxycyclohexyl)-( 2-amino-3,5-dibromobenzyl)-amine, was purified with chloroform and ethyl acetate over silica gel in a chromatographic column, the purified product was dissolved in a mixture of ethanol and ether, and the solution was acidified with concentrated hydrochloric acid. The precipitate formed thereby was collected and recrystallized from ethanol and ether, yielding N-(trans-p-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine hydrochloride, MP 233-234.5°C (decomposition).
Therapeutic Function
Expectorant
References
1) Teramoto et al. (1999), Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary diseases; Pharmacology, 59 135 2) Nowak et al. (1995), Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice; Free Radic. Biol. Med., 19 659 3) Gibbs et al. (1999), Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells; Inflamm. Res., 48 86
Ambroxol Preparation Products And Raw materials
Raw materials
Preparation Products
Ambroxol Suppliers
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- sales@trivenichemical.com
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- India
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- 6088
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- India
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- Country
- India
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View Lastest Price from Ambroxol manufacturers
- Product
- Ambroxol 18683-91-5
- Price
- US $9.00-7.00/kilograms
- Min. Order
- 10kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-02-16
- Product
- Ambroxol 18683-91-5
- Price
- US $40.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000000
- Release date
- 2023-10-31
- Product
- Ambroxol 18683-91-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-07-10