IL-1R Antagonist

Product Name: IL-1R Antagonist
CAS No.: 566914-00-9
Chemical Name: IL-1R Antagonist
Synonyms: IL-1R Antagonist;TLR1, 10 mM in DMSO;IL-1R antagonist(TLR1);I912552 IL-1R Antagonist,98%;TLR1,TLR-1,TLR 1,Inhibitor,MyD88,inhibit;Benzenepropanamide, N-[(1S)-2-methyl-1-(pyrrolidinylcarbonyl)propyl]-;Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-;N-[(2S)-3-Methyl-1-oxo-1-(1-pyrrolidinyl)-2-butanyl]-3-phenylpropanamide;(S)-N-(3-Methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-3-phenylpropanamide
CBNumber: CB11038456
Molecular Formula: C18H26N2O2
Formula Weight: 302.41
MOL File: 566914-00-9.mol

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IL-1R Antagonist Property

storage temp.: 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21349
Product name: IL-1R Antagonist
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 21349
Product name: IL-1R Antagonist
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 21349
Product name: IL-1R Antagonist
Purity: ≥98%
Packaging: 10mg
Price: $100
Updated: 2024/03/01

Biosynth Carbosynth

Product number: BA163771
Product name: IL-1R Antagonist
Packaging: 500ug
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BA163771
Product name: IL-1R Antagonist
Packaging: 1mg
Price: $150
Updated: 2021/12/16

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IL-1R Antagonist Chemical Properties,Usage,Production

Uses

TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].

Biological Activity

Cell permeable: yes', 'Primary Target
TIR domain-mediated MyD88/IL1-RI interaction', 'Product does not compete with ATP.', 'Reversible: no

in vivo

TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.)^[1].

References

[1] Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6. DOI:10.1073/pnas.0932746100

IL-1R Antagonist Preparation Products And Raw materials

Raw materials

Preparation Products

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IL-1R Antagonist Suppliers

CHINA 47 United Kingdom 1 United States 5 Global 53

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566914-00-9, IL-1R AntagonistRelated Search:

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IL-1R Antagonist

Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-

(S)-N-(3-Methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-3-phenylpropanamide

Benzenepropanamide, N-[(1S)-2-methyl-1-(pyrrolidinylcarbonyl)propyl]-

N-[(2S)-3-Methyl-1-oxo-1-(1-pyrrolidinyl)-2-butanyl]-3-phenylpropanamide

IL-1R antagonist(TLR1)

TLR1,TLR-1,TLR 1,Inhibitor,MyD88,inhibit

I912552 IL-1R Antagonist,98%

TLR1, 10 mM in DMSO

566914-00-9