2,4-Difluoro-6-hydroxybenzaldehyde
- Product Name
- 2,4-Difluoro-6-hydroxybenzaldehyde
- CAS No.
- 136516-64-8
- Chemical Name
- 2,4-Difluoro-6-hydroxybenzaldehyde
- Synonyms
- 4,6-Difluoro-2-hydroxybenzaldehyde;2,4-Difluoro-6-hydroxybenzaldehyde;Benzaldehyde, 2,4-difluoro-6-hydroxy-;Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)
- CBNumber
- CB11048525
- Molecular Formula
- C7H4F2O2
- Formula Weight
- 158.1
- MOL File
- 136516-64-8.mol
2,4-Difluoro-6-hydroxybenzaldehyde Property
- Melting point:
- 32℃
- Boiling point:
- 207.6±35.0 °C(Predicted)
- Density
- 1.464±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.18±0.15(Predicted)
- InChI
- InChI=1S/C7H4F2O2/c8-4-1-6(9)5(3-10)7(11)2-4/h1-3,11H
- InChIKey
- MIHBQNSVCKHGOA-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C(O)C=C(F)C=C1F
Safety
- Hazard Codes
- Xi
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- D451943
- Product name
- 2,4-Difluoro-6-hydroxybenzaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D451943
- Product name
- 2,4-Difluoro-6-hydroxybenzaldehyde
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- PC3686
- Product name
- 2,4-Difluoro-6-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $182
- Updated
- 2021/12/16
- Product number
- X9948
- Product name
- 2,4-Difluoro-6-hydroxybenzaldehyde
- Packaging
- 250mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 075691
- Product name
- 2,4-Difluoro-6-hydroxybenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $509
- Updated
- 2021/12/16
2,4-Difluoro-6-hydroxybenzaldehyde Chemical Properties,Usage,Production
Synthesis
50-00-0
2713-34-0
136516-64-8
Step A: 3,5-difluorophenol (2.6 g, 20 mmol) was dissolved in acetonitrile (50 mL) and triethylamine (14 mL, 100 mmol) was added. Magnesium chloride (3.8 g, 40 mmol) and paraformaldehyde (6.4 g, 200 mmol) were then added sequentially. The resulting inhomogeneous mixture was reacted at 60 °C with vigorous stirring for 16 hours. Upon completion of the reaction, the mixture was diluted with deionized water (200 mL) and the pH was adjusted to <2 with 1 M aqueous hydrochloric acid. the reaction mixture was extracted with ethyl acetate (200 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2,4-difluoro-6-hydroxybenzaldehyde (2.6 g, 82% yield) as a red oily product. Mass spectrometry analysis showed m/z 157.1 [M-H]-.
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 4, p. 1473 - 1482
[2] Patent: WO2013/101974, 2013, A1. Location in patent: Paragraph 00614; 00615
[3] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 327; 328
2,4-Difluoro-6-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Difluoro-6-hydroxybenzaldehyde manufacturers
- Product
- Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI) 136516-64-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.7%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI) 136516-64-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31