PD407824

Product Name: PD407824
CAS No.: 622864-54-4
Chemical Name: PD407824
Synonyms: PD407824;PD 0407824;PD-407824, ≥98% (HPLC);9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-
CBNumber: CB11075013
Molecular Formula: C20H12N2O3
Formula Weight: 328.32
MOL File: 622864-54-4.mol

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PD407824 Property

Density: 1.507±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
pka: 9.02±0.20(Predicted)
form: powder
color: yellow to orange

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0111
Product name: PD-407824
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0111
Product name: PD-407824
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $576
Updated: 2024/03/01

Cayman Chemical

Product number: 25989
Product name: PD 407824
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 25989
Product name: PD 407824
Purity: ≥98%
Packaging: 5mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 25989
Product name: PD 407824
Purity: ≥98%
Packaging: 10mg
Price: $245
Updated: 2024/03/01

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PD407824 Chemical Properties,Usage,Production

Description

PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC₅₀s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC₅₀ = 3.4 μM), Cdk4 (IC₅₀ = 3.75 μM), as well as c-Src and the PDGF and FGF receptors (IC₅₀s = >50 μM for all), and other Cdks (IC₅₀s = >50 μM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 μM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.

Uses

PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.

Uses

PD-407824 is a Wee1/Chk1 inhibitor useful as cancer treatments.

Biological Activity

Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC 50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC 50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μ M for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.

Biochem/physiol Actions

PD-407824 is a Wee1/Chk1 inhibitor.

storage

Store at +4°C

PD407824 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD407824 Suppliers

Canada 1 China 30 Germany 1 India 1 United Kingdom 1 United States 6 Global 40

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Fax: 86-21-50328109
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Country: China
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Chemsky (shanghai) International Co.,Ltd

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Email: shchemsky@sina.com
Country: China
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Sigma-Aldrich

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EMMX Biotechnology LLC

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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622864-54-4, PD407824Related Search:

4-METHYL-2,3-DIHYDRO-ISOINDOL-1-ONE PD407824

PD 0407824

PD407824

9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-

PD-407824, ≥98% (HPLC)

622864-54-4

C20H12N2O3

Amines

Aromatics

Inhibitors

Intermediates & Fine Chemicals

Pfizer compounds

Pharmaceuticals