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PD407824

Product Name
PD407824
CAS No.
622864-54-4
Chemical Name
PD407824
Synonyms
PD407824;PD 0407824;PD-407824, ≥98% (HPLC);9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-
CBNumber
CB11075013
Molecular Formula
C20H12N2O3
Formula Weight
328.32
MOL File
622864-54-4.mol
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PD407824 Property

Density 
1.507±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
pka
9.02±0.20(Predicted)
form 
powder
color 
yellow to orange
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0111
Product name
PD-407824
Purity
≥98% (HPLC)
Packaging
5mg
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0111
Product name
PD-407824
Purity
≥98% (HPLC)
Packaging
25mg
Price
$576
Updated
2024/03/01
Cayman Chemical
Product number
25989
Product name
PD 407824
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
25989
Product name
PD 407824
Purity
≥98%
Packaging
5mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
25989
Product name
PD 407824
Purity
≥98%
Packaging
10mg
Price
$245
Updated
2024/03/01
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PD407824 Chemical Properties,Usage,Production

Description

PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 μM), Cdk4 (IC50 = 3.75 μM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 μM for all), and other Cdks (IC50s = >50 μM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 μM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.

Uses

PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.

Uses

PD-407824 is a Wee1/Chk1 inhibitor useful as cancer treatments.

Biological Activity

Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC 50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC 50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μ M for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.

Biochem/physiol Actions

PD-407824 is a Wee1/Chk1 inhibitor.

storage

Store at +4°C

PD407824 Preparation Products And Raw materials

Raw materials

Preparation Products

622864-54-4, PD407824Related Search:


  • PD 0407824
  • PD407824
  • 9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
  • Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-
  • PD-407824, ≥98% (HPLC)
  • 622864-54-4
  • C20H12N2O3
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer compounds
  • Pharmaceuticals