6-Quinazolinecarboxylic acid (9CI)
- Product Name
- 6-Quinazolinecarboxylic acid (9CI)
- CAS No.
- 676326-53-7
- Chemical Name
- 6-Quinazolinecarboxylic acid (9CI)
- Synonyms
- quinazoline-6-carboxylic acid;6-Quinazolinecarboxylic acid;Quinazoline-6-carboxylic ...;Quinazoline-6-caeboxylic acid;Quinazoline-7-carboxylic acid;6-Quinazolinecarboxylic acid (9CI)
- CBNumber
- CB11082358
- Molecular Formula
- C9H6N2O2
- Formula Weight
- 174.16
- MOL File
- 676326-53-7.mol
6-Quinazolinecarboxylic acid (9CI) Property
- Boiling point:
- 359.5±17.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.78±0.30(Predicted)
- Appearance
- Yellow to brown Solid
Safety
- HS Code
- 2933992000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- Q670130
- Product name
- Quinazoline-6-carboxylicacid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 068539
- Product name
- 6-Quinazolinecarboxylic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $1235
- Updated
- 2021/12/16
- Product number
- 0413AC
- Product name
- Quinazoline-6-carboxylicacid
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- CHM0393813
- Product name
- QUINAZOLINE-6-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.4
- Updated
- 2021/12/16
- Product number
- CM108438
- Product name
- quinazoline-6-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $636
- Updated
- 2021/12/16
6-Quinazolinecarboxylic acid (9CI) Chemical Properties,Usage,Production
Uses
Quinazoline-7-carboxylic Acid is a derivative of Quinazoline (Q670100) which is used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. Quinazoline is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Synthesis
849805-65-8
676326-53-7
Ethyl quinazoline-6-carboxylate (79 mg, 0.391 mmol) was dissolved in ethanol (4 mL), 1 N aqueous sodium hydroxide (4 mL) was added, and the reaction was stirred for 1 h at room temperature. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 4 with 1 N hydrochloric acid, followed by vacuum evaporation to remove the solvent. Ethanol was added to the residue and the organic layer was concentrated. The residue was dissolved in ethyl acetate-tetrahydrofuran mixed solvent and dried with anhydrous magnesium sulfate followed by vacuum evaporation to give quinazoline-6-carboxylic acid (15 mg, 0.086 mmol, 22% yield). The resulting product was directly used in the subsequent reaction without further purification.1H-NMR (DMSO-d6) δ (ppm): 8.09 (1H, d, J = 8.8 Hz), 8.44 (1H, dd, J = 2.0, 8.8 Hz), 8.83 (1H, d, J = 2.0 Hz), 9.39 (1H, s), 9.79 (1H, s).
References
[1] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 58-59
[2] Patent: EP1669348, 2006, A1. Location in patent: Page/Page column 66-67
6-Quinazolinecarboxylic acid (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
6-Quinazolinecarboxylic acid (9CI) Suppliers
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View Lastest Price from 6-Quinazolinecarboxylic acid (9CI) manufacturers
- Product
- 6-Quinazolinecarboxylic acid (9CI) 676326-53-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 6-Quinazolinecarboxylic acid (9CI) 676326-53-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 6-Quinazolinecarboxylic acid (9CI) 676326-53-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12