ChemicalBook > CAS DataBase List > 6-AMino-2,3-dihydroisoindol-1-one

6-AMino-2,3-dihydroisoindol-1-one

Product Name
6-AMino-2,3-dihydroisoindol-1-one
CAS No.
675109-45-2
Chemical Name
6-AMino-2,3-dihydroisoindol-1-one
Synonyms
6-Amino-1-isoindolinone;6-aminoisoindolin-1-one;6-AMino-2,3-dihydroisoindol-1-one;6-amino-2,3-dihydro-1H-Isoindol-1-one;1H-Isoindol-1-one, 6-aMino-2,3-dihydro-;1H-Isoindol-1-one, 6-amino-2,3-dihydro- (9CI);4,4'-METHYLENEBIS(6-BROMO-N,N-DIMETHYLANILINE)
CBNumber
CB11087661
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
675109-45-2.mol
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6-AMino-2,3-dihydroisoindol-1-one Property

Melting point:
247 °C
Boiling point:
499.9±45.0 °C(Predicted)
Density 
1.307±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
14.77±0.20(Predicted)
Appearance
Light yellow to green yellow Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
A611595
Product name
6-Aminoisoindolin-1-one
Packaging
100mg
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
113139
Product name
6-Aminoisoindolin-1-one
Packaging
1g
Price
$200
Updated
2021/12/16
Matrix Scientific
Product number
113139
Product name
6-Aminoisoindolin-1-one
Packaging
5g
Price
$564
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0114086
Product name
6-AMINO-2,3-DIHYDRO-1H-ISOINDOL-1-ONE
Purity
95.00%
Packaging
1G
Price
$983.52
Updated
2021/12/16
AK Scientific
Product number
0385AC
Product name
6-Amino-2,3-dihydro-1H-isoindol-1-one
Packaging
25g
Price
$1357
Updated
2021/12/16
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6-AMino-2,3-dihydroisoindol-1-one Chemical Properties,Usage,Production

Uses

6-AMino-2,3-dihydroisoindol-1-one is used in the synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on the isoindolone skeleton.

Synthesis

110568-64-4

675109-45-2

General procedure for the synthesis of 6-amino-isoindolin-1-one from 6-nitro-isoindolin-1-one: A suspension of intermediate 6B (1.6 g, 8.98 mmol) and Pd/C (0.18 g) in methanol (100 mL) was stirred for 4 hr under hydrogen (1 atm) atmosphere. After completion of the reaction, the reaction mixture was filtered and the filter cake was washed with methanol. After combining the filtrates, the solvent was removed by concentration under reduced pressure. The crude product was ground with methanol (10 mL) and subsequently dried under reduced pressure to afford intermediate 6 (800 mg, 5.40 mmol, 60.1% yield) as a beige solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 4.15 (s, 2H), 5.26 (s, 2H), 6.77 (dd, J = 8.25, 2.20 Hz, 1H), 6.80 (s, 1H), 7.16 (d, J = 8.79 Hz, 1H), 8.29 (s, 1H). The mass spectrum (ESI) showed m/z 149.2 ([M + H]+).

References

[1] Patent: WO2008/79759, 2008, A1. Location in patent: Page/Page column 91-92
[2] Patent: WO2008/79836, 2008, A2. Location in patent: Page/Page column 87
[3] Chemische Berichte, 1934, vol. 67, p. 675,681
[4] Patent: WO2010/10184, 2010, A1. Location in patent: Page/Page column 59
[5] Patent: US2004/58970, 2004, A1. Location in patent: Page 14

6-AMino-2,3-dihydroisoindol-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-AMino-2,3-dihydroisoindol-1-one manufacturers

Career Henan Chemical Co
Product
6-AMino-2,3-dihydroisoindol-1-one 675109-45-2
Price
US $2.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
ask
Release date
2019-12-24

675109-45-2, 6-AMino-2,3-dihydroisoindol-1-oneRelated Search:

4-nitroisoindolin-1-one 4-Nitrophthalimide 4-Nitro-N-methylphthalimide 4-Aminophthalimide 4-Chloro-5-nitrophthalimide N-CHLOROMETHYL-4-NITROPHTHALIMIDE 4,5-DIANILINOPHTHALIMIDE 4-AMINO-N-METHYLPHTHALIMIDE 4-(5-AMINO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID METHYL ESTER 5-AMINO-2-P-TOLYL-ISOINDOLE-1,3-DIONE (5-NITRO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ACETIC ACID 4-NITRO-N-PHENYLPHTHALIMIDE N-(O-NITROPHENYL)4-NITROPHTHALIMIDE 5-AMINO-2-NAPHTHALEN-2-YL-ISOINDOLE-1,3-DIONE 4-(5-NITRO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID 5-(ethylamino)-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione 5-AMINO-2-NAPHTHALEN-1-YL-ISOINDOLE-1,3-DIONE 5-amino-2-phenyl-2,3-dihydro-1H-isoindole-1,3-dione

  • 1H-Isoindol-1-one, 6-amino-2,3-dihydro- (9CI)
  • 1H-Isoindol-1-one, 6-aMino-2,3-dihydro-
  • 6-AMino-2,3-dihydroisoindol-1-one
  • 6-amino-2,3-dihydro-1H-Isoindol-1-one
  • 6-aminoisoindolin-1-one
  • 4,4'-METHYLENEBIS(6-BROMO-N,N-DIMETHYLANILINE)
  • 6-Amino-1-isoindolinone
  • 675109-45-2
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • ALCOHOL
  • AMINEPRIMARY