4-Aminophthalimide

Product Name: 4-Aminophthalimide
CAS No.: 3676-85-5
Chemical Name: 4-Aminophthalimide
Synonyms: RMA-93;AKOS 92231;Roxadustat-003;4-AMINOPHTHALIMIDE;4-Amino-phthalamide;5-AMINO PHTHALIMIDE;TIMTEC-BB SBB001589;Phthalimide, 4-amino-;OTAVA-BB BB0111070393;SPECS AE-641/30105046
CBNumber: CB9671267
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 3676-85-5.mol

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4-Aminophthalimide Property

Melting point:: 290 °C
Boiling point:: 288.82°C (rough estimate)
Density: 1.3264 (rough estimate)
refractive index: 1.5770 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 10.75±0.20(Predicted)
form: solid
Appearance: Light yellow to yellow Solid
CAS DataBase Reference: 3676-85-5(CAS DataBase Reference)
NIST Chemistry Reference: 4-Aminophthalimide(3676-85-5)
EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 5-amino- (3676-85-5)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-43-36-25
Safety Statements: 24/25-45-36/37-26
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29251900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS000148
Product name: 5-Amino-1H-isoindole-1,3(2H)-dione
Purity: AldrichCPR
Packaging: 250mg
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: A0966
Product name: 4-Aminophthalimide
Purity: >98.0%(GC)
Packaging: 5g
Price: $73
Updated: 2025/07/31

TCI Chemical

Product number: A0966
Product name: 4-Aminophthalimide
Purity: >98.0%(GC)
Packaging: 25g
Price: $216
Updated: 2025/07/31

TRC

Product number: A619070
Product name: 4-Aminophthalimide
Packaging: 1g
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA71627
Product name: 4-Aminophthalimide
Packaging: 5G
Price: $45
Updated: 2021/12/16

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4-Aminophthalimide Chemical Properties,Usage,Production

Chemical Properties

YELLOW-BROWN POWDER

Uses

4-Aminophthalimide is used in research as a fluorescent labeling compound.

Synthesis

89-40-7

3676-85-5

General procedure for the synthesis of 4-amino phthalimide from 4-nitrophthalimide: 4-nitrophthalimide (LOOGR) was placed in a hydrogenation reactor and dissolved in 600 mL of dimethylformamide (DMF). Nickel Nguyenay catalyst (20 g, wet weight) was added to this solution and the hydrogenation reaction was initiated at 20-30 °C and 20-40 psi hydrogen pressure. After the exothermic phenomenon of the reaction was over, the hydrogen pressure was increased to 40-60 psi and the reaction temperature was raised to 40-50 °C. Upon completion of the hydrogenation reaction, the reaction mixture was filtered while hot to remove the catalyst. Subsequently, dimethylformamide was recovered from the filtrate by distillation under reduced pressure at 60-80 °C. To the residue, 500 mL of water was added and stirred for 20-30 minutes. The product was separated by filtration and dried at 60-70 °C to give 4-amino phthalimide as a yellow crystalline solid (82 g, 97% yield). Melting point: 293-295°C.

References

[1] Patent: WO2004/43919, 2004, A1. Location in patent: Page 8
[2] Patent: US2011/77394, 2011, A1. Location in patent: Page/Page column 15
[3] Patent: WO2004/43919, 2004, A1. Location in patent: Page 9
[4] ChemCatChem, 2017, vol. 9, # 6, p. 1128 - 1134
[5] Patent: CN104447496, 2017, B. Location in patent: Paragraph 0067; 0070; 0071

4-Aminophthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Aminophthalimide Suppliers

Americas 1 Belgium 3 CHINA 161 Europe 2 Germany 6 India 16 Japan 2 Russia 2 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 3 United Kingdom 19 United States 34 Global 254

J & K SCIENTIFIC LTD.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Adamas Reagent, Ltd.

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View Lastest Price from 4-Aminophthalimide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Aminophthalimide 3676-85-5
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2025-03-11

Asia Chem I and E (Jiangsu) Co Ltd

Product: 4-Aminophthalimide 3676-85-5
Price: US $209.30/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 4tons/month
Release date: 2021-09-24

Sichuan Zhuoyu Yantang Technology Co., Ltd.

Product: 4-Aminophthalimide 3676-85-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-26

3676-85-5, 4-AminophthalimideRelated Search:

4-Dimethylaminobenzaldehyde Bismaleimide 4-Dimethylaminopyridine Potassium phthalimide 4-Nitrophthalimide 4-Dimethylaminobenzoic acid DIALIFOS O-Phthalimide N-Hydroxyphthalimide N-Methylphthalimide Succinimide 1,2-Cyclohexanedicarboximide 2-Dimethylaminoethanol 4-Nitro-N-methylphthalimide 4-Chloro-5-nitrophthalimide 4-AMINO-N-METHYLPHTHALIMIDE N-CHLOROMETHYL-4-NITROPHTHALIMIDE (5-NITRO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ACETIC ACID

1H-Isoindole-1,3(2H)-dione, 5-amino-

4-Amino-phthalamide

5-Amino-1H-isoindole-1,3(2H)-dione

5-amino-1h-isoindole-3(2h)-dione

4-Aminophthalimide 95+%

Isoindole, 1,3(2H)-dione, 5-amino-

Phthalimide, 4-amino-

5-AMINO PHTHALIMIDE

5-AMINO-ISOINDOLE-1,3-DIONE

4-AMINOPHTHALIMIDE

AKOS 92231

OTAVA-BB BB0111070393

SPECS AE-641/30105046

TIMTEC-BB SBB001589

5-aminoisoindoline-1,3-dione

4-AMINOPHTHALIMIDE 98%

4-Aminophthalimide, 97% (UV-VIS)

5-Amino-2H-isoindole-1,3-dione

4-Aminophthalimide,97%

5-aMino-2,3-dihydro-1H-isoindole-1,3-dione

4-AMinophthaliMide, 97% 1GR

5-aminoisoindoline-1,3-quinone

4-Aminophthalimide &gt

Roxadustat-003

Roxadustat Impurity 92

5-Amino-1<i>H</i>-isoindole-1,3(2<i>H</i>)-dione

RMA-93

3676-85-5

3676-85-4

Phthalic Acids, Esters and Derivatives