Amlodipine mesylate

Product Name: Amlodipine mesylate
CAS No.: 246852-12-0
Chemical Name: Amlodipine mesylate
Synonyms: Amlodipine mesylate USP/EP/BP;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid
CBNumber: CB11106917
Molecular Formula: C20H25ClN2O5.CH4O3S
Formula Weight: 0
MOL File: 246852-12-0.mol

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Amlodipine mesylate Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0014471
Product name: AMLODIPINE MESYLATE
Purity: 95.00%
Packaging: 5MG
Price: $495.12
Updated: 2021/12/16

Matrix Scientific

Product number: 095040
Product name: 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

AK Scientific

Product number: 1891AB
Product name: 3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylatemethanesulfonate
Packaging: 250mg
Price: $1051
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014471
Product name: AMLODIPINE MESYLATE
Purity: 95.00%
Packaging: 1G
Price: $1575
Updated: 2021/12/16

Matrix Scientific

Product number: 095040
Product name: 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

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Amlodipine mesylate Chemical Properties,Usage,Production

Uses

Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer[1][2][3].

in vivo

Amlodipine mesylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice^[4].
Amlodipine mesylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice^[3].

Animal Model:	ATP2B1^loxP/loxP mice^[4]
Dosage:	5 mg/kg/day
Administration:	Subcutaneously implanted osmotic pump for 2 weeks
Result:	Significantly decreased the blood pressure.

IC 50

L-type calcium channel

References

[1] Kishen G. Bulsara, et al. Amlodipine.
[2] Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. DOI:10.2165/00003495-199550030-00009
[3] Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. DOI:10.1016/j.ejphar.2004.04.006
[4] Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. DOI:10.1038/hr.2017.92

Amlodipine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Amlodipine mesylate Suppliers

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View Lastest Price from Amlodipine mesylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Amlodipine mesylate 246852-12-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Shaanxi Dideu Medichem Co. Ltd

Product: Amlodipine Mesylate 246852-12-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 600 MT
Release date: 2020-05-08

246852-12-0, Amlodipine mesylateRelated Search:

Amlodipine Amlodipine Besylate (S)-Amlodipine Amlodipine mesylate

3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate

3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di

3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid

Amlodipine mesylate USP/EP/BP

3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1

246852-12-0

C21H29ClN2O8S

C20H25ClN2O5CH4O3S