CDK1/2InhibitorIII
- Product Name
- CDK1/2InhibitorIII
- CAS No.
- 443798-55-8
- Chemical Name
- CDK1/2InhibitorIII
- Synonyms
- 2 Inhibitor III;CDK1/2InhibitorIII;Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III;5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide;1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
- CBNumber
- CB11113964
- Molecular Formula
- C15H13F2N7O2S2
- Formula Weight
- 425.44
- MOL File
- 443798-55-8.mol
CDK1/2InhibitorIII Property
- Boiling point:
- 649.1±65.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- DMSO: 10mg/mL
THF: soluble
acetone: soluble - form
- White solid
- pka
- 6.61±0.70(Predicted)
- color
- white
N-Bromosuccinimide Price
- Product number
- 217714
- Product name
- Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem
- Packaging
- 1MG
- Price
- $140
- Updated
- 2023/06/20
- Product number
- 18859
- Product name
- Cdk1/2 Inhibitor III
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 18859
- Product name
- Cdk1/2 Inhibitor III
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 18859
- Product name
- Cdk1/2 Inhibitor III
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- C228110
- Product name
- CDK1/2InhibitorIII
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
CDK1/2InhibitorIII Chemical Properties,Usage,Production
Uses
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).
Uses
Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. CDK 1/2 inhibitor III selectively inhibits CDK1 and CDK2. Studies have shown that CDK 1/2 Inhibitor III can also inhibit in vitro cellular proliferation in various human tumor cells.
General Description
A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 μM).
Biochem/physiol Actions
Cell permeable: yes
CDK1/2InhibitorIII Preparation Products And Raw materials
Raw materials
Preparation Products
CDK1/2InhibitorIII Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32159
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38630
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@advtechind.com
- Country
- United States
- ProdList
- 6075
- Advantage
- 58
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81