(2-Amino-benzyl)-carbamic acid tert-butyl ester
- Product Name
- (2-Amino-benzyl)-carbamic acid tert-butyl ester
- CAS No.
- 162046-50-6
- Chemical Name
- (2-Amino-benzyl)-carbamic acid tert-butyl ester
- Synonyms
- 2-(Boc-aminomethyl)aniline;tert-Butyl 2-aMinobenzylcarbaMate;Carbamic acid, N-[(2-aminophenyl)methyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB11116950
- Molecular Formula
- C12H18N2O2
- Formula Weight
- 222.28
- MOL File
- 162046-50-6.mol
(2-Amino-benzyl)-carbamic acid tert-butyl ester Property
- Melting point:
- 93℃
- Boiling point:
- 382.5±25.0 °C(Predicted)
- Density
- 1.095±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.10±0.46(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B900533
- Product name
- tert-Butyl2-aminobenzylcarbamate
- Packaging
- 25mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FB140900
- Product name
- tert-Butyl 2-aminobenzylcarbamate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- AS100879
- Product name
- 2-(Boc-aminomethyl)aniline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- FB140900
- Product name
- tert-Butyl 2-aminobenzylcarbamate
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FB140900
- Product name
- tert-Butyl 2-aminobenzylcarbamate
- Packaging
- 500mg
- Price
- $225
- Updated
- 2021/12/16
(2-Amino-benzyl)-carbamic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
24424-99-5
4403-69-4
162046-50-6
General procedure for the synthesis of tert-butyl (2-aminobenzyl)-carbamate from di-tert-butyl dicarbonate and 2-aminobenzylamine: 2-aminobenzylamine (6.0 g, 49.2 mmol) was dissolved in dichloromethane and stirred in an ice bath under nitrogen protection. A dichloromethane solution of di-tert-butyl dicarbonate (Boc)2O (10.7 g, 49.2 mmol) was added slowly and dropwise. The reaction mixture was then warmed up to room temperature to continue the reaction. After completion of the reaction, the reaction solution was washed sequentially with distilled water and saturated saline, dried over anhydrous sodium sulfate and filtered. The solvent was removed by distillation under reduced pressure and stirred overnight. The intermediate (2-aminobenzyl)-carbamic acid tert-butyl ester 5,10.5 g was obtained in 96.2% yield.
References
[1] Patent: CN104016944, 2016, B. Location in patent: Paragraph 0014-0015; 0046-0047
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 7, p. 1885 - 1889
[3] Angew. Chem., 2017, vol. 129, # 7, p. 1911 - 1915,5
[4] Organic and Biomolecular Chemistry, 2011, vol. 9, # 3, p. 656 - 658
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 9, p. 1661 - 1669
(2-Amino-benzyl)-carbamic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (2-Amino-benzyl)-carbamic acid tert-butyl ester manufacturers
- Product
- (2-Aminobenzyl)carbamic acid tert-butyl ester 162046-50-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09