ChemicalBook > CAS DataBase List > (2-Amino-benzyl)-carbamic acid tert-butyl ester

(2-Amino-benzyl)-carbamic acid tert-butyl ester

Product Name
(2-Amino-benzyl)-carbamic acid tert-butyl ester
CAS No.
162046-50-6
Chemical Name
(2-Amino-benzyl)-carbamic acid tert-butyl ester
Synonyms
2-(Boc-aminomethyl)aniline;tert-Butyl 2-aMinobenzylcarbaMate;Carbamic acid, N-[(2-aminophenyl)methyl]-, 1,1-dimethylethyl ester
CBNumber
CB11116950
Molecular Formula
C12H18N2O2
Formula Weight
222.28
MOL File
162046-50-6.mol
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(2-Amino-benzyl)-carbamic acid tert-butyl ester Property

Melting point:
93℃
Boiling point:
382.5±25.0 °C(Predicted)
Density 
1.095±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
12.10±0.46(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B900533
Product name
tert-Butyl2-aminobenzylcarbamate
Packaging
25mg
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140900
Product name
tert-Butyl 2-aminobenzylcarbamate
Packaging
100mg
Price
$65
Updated
2021/12/16
Activate Scientific
Product number
AS100879
Product name
2-(Boc-aminomethyl)aniline
Purity
95%
Packaging
250mg
Price
$104
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140900
Product name
tert-Butyl 2-aminobenzylcarbamate
Packaging
250mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140900
Product name
tert-Butyl 2-aminobenzylcarbamate
Packaging
500mg
Price
$225
Updated
2021/12/16
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(2-Amino-benzyl)-carbamic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

24424-99-5

4403-69-4

162046-50-6

General procedure for the synthesis of tert-butyl (2-aminobenzyl)-carbamate from di-tert-butyl dicarbonate and 2-aminobenzylamine: 2-aminobenzylamine (6.0 g, 49.2 mmol) was dissolved in dichloromethane and stirred in an ice bath under nitrogen protection. A dichloromethane solution of di-tert-butyl dicarbonate (Boc)2O (10.7 g, 49.2 mmol) was added slowly and dropwise. The reaction mixture was then warmed up to room temperature to continue the reaction. After completion of the reaction, the reaction solution was washed sequentially with distilled water and saturated saline, dried over anhydrous sodium sulfate and filtered. The solvent was removed by distillation under reduced pressure and stirred overnight. The intermediate (2-aminobenzyl)-carbamic acid tert-butyl ester 5,10.5 g was obtained in 96.2% yield.

References

[1] Patent: CN104016944, 2016, B. Location in patent: Paragraph 0014-0015; 0046-0047
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 7, p. 1885 - 1889
[3] Angew. Chem., 2017, vol. 129, # 7, p. 1911 - 1915,5
[4] Organic and Biomolecular Chemistry, 2011, vol. 9, # 3, p. 656 - 658
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 9, p. 1661 - 1669

(2-Amino-benzyl)-carbamic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (2-Amino-benzyl)-carbamic acid tert-butyl ester manufacturers

Career Henan Chemical Co
Product
(2-Aminobenzyl)carbamic acid tert-butyl ester 162046-50-6
Price
US $1.00/g
Min. Order
1g
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-09

162046-50-6, (2-Amino-benzyl)-carbamic acid tert-butyl esterRelated Search:

(2-Amino-benzyl)-carbamic acid tert-butyl ester 1,2,3,5-TETRAHYDRO-BENZO[E][1,4]DIAZEPINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 3-METHYL ESTER 4-AMINO-3-(BOC-AMINOMETHYL)-BENZOIC ACID 8-AMINO-1,2,3,5-TETRAHYDRO-BENZO[E][1,4]DIAZEPINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 1,2,3,5-TETRAHYDRO-BENZO[E][1,4]DIAZEPINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 4-BOC-9-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 4-BOC-7,8-DIMETHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE [1-(2-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER BOC-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 3-(N-BOC)AMINO-3-(2-NITRO-PHENYL)-PROPIONIC ACID 4-BOC-7-BROMO-1,2,3,5-TETRAHYDRO-BENZO[E][1,4]DIAZEPINE-3-CARBOXYLIC ACID 3-METHYL ESTER BOC-2,4-DINITRO-DL-PHENYLGLYCINE BOC-(S)-3-AMINO-3-(2-NITRO-PHENYL)-PROPIONIC ACID 4-BOC-9-METHYL-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE 4-BOC-8-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE BOC-(R)-3-AMINO-3-(2-NITRO-PHENYL)-PROPIONIC ACID RARECHEM GT HW 0229 2-(2-AMINO-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • tert-Butyl 2-aMinobenzylcarbaMate
  • 2-(Boc-aminomethyl)aniline
  • Carbamic acid, N-[(2-aminophenyl)methyl]-, 1,1-dimethylethyl ester
  • 162046-50-6