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Rutamycin

Product Name
Rutamycin
CAS No.
1404-59-7
Chemical Name
Rutamycin
Synonyms
A-272;RR-32705;Rutamycin;RRNo-32705;oligomycin D;26-Demethyloligomycin A;RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-,(1S,2'R,4E,5'S,6S,6'S,7S,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-, (1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-
CBNumber
CB11120704
Molecular Formula
C44H72O11
Formula Weight
777.042
MOL File
1404-59-7.mol
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Rutamycin Property

Melting point:
116-119°
alpha 
D20 -62° (c = 1.36 in CHCl3)
Boiling point:
883.4±65.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
A lyophilisate
pka
12.52±0.70(Predicted)
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Safety

RIDADR 
2811
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 oral in mouse: 800mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20184
Product name
Oligomycin D
Purity
≥95%
Packaging
500μg
Price
$335
Updated
2024/03/01
Cayman Chemical
Product number
20184
Product name
Oligomycin D
Purity
≥95%
Packaging
2.5mg
Price
$751
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0012448
Product name
RUTAMYCIN
Purity
95.00%
Packaging
5MG
Price
$501.12
Updated
2021/12/16
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Rutamycin Chemical Properties,Usage,Production

Description

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 μM.

Uses

Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

Uses

Oligomycin D is an inhibitor of mitochondrial F1F0-ATPase.

Rutamycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Rutamycin Suppliers

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1404-59-7, RutamycinRelated Search:

Chloramphenicol Natamycin OLIGOMYCIN Rutamycin

  • oligomycin D
  • 26-Demethyloligomycin A
  • A-272
  • RR-32705
  • RRNo-32705
  • RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A
  • Rutamycin
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-,(1S,2'R,4E,5'S,6S,6'S,7S,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-, (1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-
  • 1404-59-7
  • C44H72O11