ChemicalBook > CAS DataBase List > BOC-D-NVA-OH

BOC-D-NVA-OH

Product Name
BOC-D-NVA-OH
CAS No.
57521-85-4
Chemical Name
BOC-D-NVA-OH
Synonyms
N-Boc-D-norvaline dicyclohexylammonium salt;BOC-D-NORVALINE;Boc-D-Norvaline-OH;Boc-D-Nva;NSC 343953;BOC-D-NVA-OH;Boc-D-NVal-OH;Cbz-D-Norvaline;BOC-D-APE(2)-OH;RARECHEM EM WB 0169
CBNumber
CB1112861
Molecular Formula
C10H19NO4
Formula Weight
217.26
MOL File
57521-85-4.mol
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BOC-D-NVA-OH Property

Boiling point:
348.3±25.0 °C(Predicted)
Density 
1.081±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Powder
pka
4.02±0.20(Predicted)
color 
White
BRN 
5260625
CAS DataBase Reference
57521-85-4(CAS DataBase Reference)
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
12688
Product name
Boc-D-Nva-OH
Purity
≥98.0% (TLC)
Packaging
5G
Price
$650
Updated
2022/05/15
Usbiological
Product number
236214
Product name
Boc-D-norvaline
Packaging
1g
Price
$163
Updated
2021/12/16
TRC
Product number
B657025
Product name
BOC-D-NVA-OH
Packaging
25g
Price
$250
Updated
2021/12/16
Usbiological
Product number
264825
Product name
Boc-D-norvaline
Packaging
2g
Price
$333
Updated
2021/12/16
AK Scientific
Product number
V6722
Product name
Boc-D-norvaline
Packaging
1g
Price
$21
Updated
2021/12/16
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BOC-D-NVA-OH Chemical Properties,Usage,Production

Chemical Properties

Clear colorless viscid liquid

Uses

BOC-D-NVA-OH is a chemical reagent used in the preparation of benzothiophene inhibitors of MK2. Also has been used to synthesize pyrrolidine diketopiperazines to inhibit melanoma

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

2013-12-9

24424-99-5

57521-85-4

General procedure for the synthesis of (R)-2-((tert-butylcarbonyl)amino)pentanoic acid from D-norvaline and di-tert-butyl dicarbonate: (R)-2-aminopentanoic acid (2.343 g) and Na2CO3 (2.120 g) were dissolved in water (60.00 mL) to form a mixture. A solution of THF (20 mL) in Boc2O (4.88 mL) was added slowly and dropwise to the mixture at room temperature. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was washed with ether (2 × 20 mL), followed by adjusting the pH of the aqueous phase with K2SO4 solution to 3. The aqueous phase was extracted with EtOAc (2 × 30 mL), the organic phases were combined, and the solvents were evaporated after drying to give (R)-2-((tert-butylcarbonyl)amino)pentanoic acid (4 g) as a viscous oil product. Mass spectrometry (ESI) analysis showed that the theoretical molecular weight of C10H19NO4 was 217; the measured value was 216 [M-H].

References

[1] Patent: US5206235, 1993, A
[2] Patent: WO2015/180612, 2015, A1. Location in patent: Page/Page column 70

BOC-D-NVA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-NVA-OH Suppliers

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View Lastest Price from BOC-D-NVA-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-D-NVal-OH 57521-85-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-10-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
BOC-D-NVA-OH 57521-85-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
BOC-D-NVA-OH 57521-85-4
Price
US $1.00/g
Min. Order
100g
Purity
>98%
Supply Ability
g/kg/Ton
Release date
2020-01-14

57521-85-4, BOC-D-NVA-OHRelated Search:

BOC-GLN-ONP Boc-D-Glutamine Nα-Boc-Nω-nitro-D-arginine N-Boc-N'-(2-chlorobenzyloxycarbonyl)-L-lysine Boc-D-Glu-OBzl BOC-D-LEU-OH H2O BOC-D-NLE-OH Boc-D-isoleucine (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-D-Leucine monohydrate BOC-D-ORN(Z)-OH BOC-D-Arg(Tos)-OH BOC-D-PRO-OSU Boc-D-homophenylalanine Boc-L-Glutamic acid 1-benzyl ester BOC-L-NVA-OH D(-)-Norvaline L-Norvaline

  • BOC-D-NHCH[CH3(CH2)]-COOH
  • BOC-D-NORVALINE
  • N-ALPHA-T-BUTOXYCARBONYL-D-2-AMINO-PENTANOIC ACID
  • N-ALPHA-T-BUTOXYCARBONYL-D-NORVALINE
  • N-ALPHA-T-BOC-D-NORVALINE
  • (R)-2-(BOC-AMINO)PENTANOIC ACID
  • RARECHEM EM WB 0169
  • Cbz-D-Norvaline
  • Boc-D-Nva
  • BOC-D-NORVALINE LIQUID
  • O-(PHENYLMETHYL)-L-THREONINE
  • (R)-2-(Boc-amino)pentanoic acid, Boc-D-norvaline
  • Boc-D-Norvaline-OH
  • Boc-D-norvaline (syrup)
  • NSC 343953
  • Boc-D-Nva-OH Boc-D-Norvaline
  • N-tert-Butoxycarbonyl-D-norvaline
  • N-Boc-D-norvaline dicyclohexylammonium salt
  • BOC-D-APE(2)-OH
  • BOC-D-2-AMINOVALERIC ACID
  • BOC-D-NVA-OH
  • N-(tert-butoxycarbonyl)norvaline
  • Boc-D-NVal-OH
  • Boc-D-norvaline (syrup)99%
  • D-Norvaline, N-[(1,1-dimethylethoxy)carbonyl]-
  • BOC-D-NVA-OH USP/EP/BP
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
  • Boc-<sc>D</sc>-Nva-OH
  • N-tert-butoxycarbonyl-D-norvaline, 97%min
  • 57521-85-4
  • C10HNO4
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Amino Acids