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CYCLOBENZAPRINE HCL

Product Name
CYCLOBENZAPRINE HCL
CAS No.
303-53-7
Chemical Name
CYCLOBENZAPRINE HCL
Synonyms
CYCLOBENZAPRINE;mk130;MK-130;RP-9715;9715r.p.;ro4-1577;Ro-4-1577;Proeptatriene;proheptatrien;Proheptatriene
CBNumber
CB1116384
Molecular Formula
C20H21N
Formula Weight
275.39
MOL File
303-53-7.mol
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CYCLOBENZAPRINE HCL Property

Boiling point:
bp1 175-180°
Density 
0.9504 (rough estimate)
refractive index 
1.7500 (estimate)
pka
pKa 8.47 (Uncertain)
BCS Class
1
NIST Chemistry Reference
Cyclobenzaprine(303-53-7)
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Safety

Hazardous Substances Data
303-53-7(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: 250mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
KIT7835
Product name
Cyclobenzaprine(1.0mg/mLinMethanol)
Packaging
5x1ml
Price
$105
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009177
Product name
CYCLOBENZAPRINE
Purity
95.00%
Packaging
5MG
Price
$497.28
Updated
2021/12/16
AHH
Product number
MT-49581
Product name
Cyclobenzaprine
Purity
98%
Packaging
0.05g
Price
$410
Updated
2021/12/16
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CYCLOBENZAPRINE HCL Chemical Properties,Usage,Production

Description

Cyclobenzaprine is structurally similar to tricyclic antidepressants. It acts at the brain stem level.

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

It is used as an adjuvant agent for relieving muscle spasms associated with severe diseased conditions of the muscle. A synonym of this drug is flexeril.

Uses

Relaxant (muscle).

Definition

ChEBI: 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its h drochloride salt in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

Synthesis

Cyclobenzaprine, N,N-dimethyl-3-(dibenzo[a,d]cyclohepten-5-ylidene) propylamine (15.3.9), is synthesized by reacting 5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium chloride and subsequent dehydration of the resulting carbinol (15.3.8) in acidic conditions into cyclobenzaprine (15.3.9).

CYCLOBENZAPRINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOBENZAPRINE HCL Suppliers

Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9577
Advantage
60
Capot Chemical Co.,Ltd.
Tel
+86-(0)57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29791
Advantage
60
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4391
Advantage
58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Tel
+8617731987558
Email
xingjiu@xingjiubiotech.com
Country
China
ProdList
989
Advantage
58
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View Lastest Price from CYCLOBENZAPRINE HCL manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
CYCLOBENZAPRINE HCL 303-53-7
Price
US $15.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
500MT/month
Release date
2021-12-20
Career Henan Chemical Co
Product
CYCLOBENZAPRINE HCL 303-53-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

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