CYCLOBENZAPRINE HCL

Product Name: CYCLOBENZAPRINE HCL
CAS No.: 303-53-7
Chemical Name: CYCLOBENZAPRINE HCL
Synonyms: CYCLOBENZAPRINE;mk130;MK-130;RP-9715;9715r.p.;ro4-1577;Ro-4-1577;Proeptatriene;proheptatrien;Proheptatriene
CBNumber: CB1116384
Molecular Formula: C20H21N
Formula Weight: 275.39
MOL File: 303-53-7.mol

More

Less

CYCLOBENZAPRINE HCL Property

Boiling point:: bp1 175-180°
Density: 0.9504 (rough estimate)
refractive index: 1.7500 (estimate)
pka: pKa 8.47 (Uncertain)
BCS Class: 1
NIST Chemistry Reference: Cyclobenzaprine(303-53-7)

More

Less

Safety

Hazardous Substances Data: 303-53-7(Hazardous Substances Data)
Toxicity: LD50 oral in mouse: 250mg/kg

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: KIT7835
Product name: Cyclobenzaprine(1.0mg/mLinMethanol)
Packaging: 5x1ml
Price: $105
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009177
Product name: CYCLOBENZAPRINE
Purity: 95.00%
Packaging: 5MG
Price: $497.28
Updated: 2021/12/16

AHH

Product number: MT-49581
Product name: Cyclobenzaprine
Purity: 98%
Packaging: 0.05g
Price: $410
Updated: 2021/12/16

More

Less

CYCLOBENZAPRINE HCL Chemical Properties,Usage,Production

Description

Cyclobenzaprine is structurally similar to tricyclic antidepressants. It acts at the brain stem level.

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

It is used as an adjuvant agent for relieving muscle spasms associated with severe diseased conditions of the muscle. A synonym of this drug is flexeril.

Uses

Relaxant (muscle).

Definition

ChEBI: 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its h drochloride salt in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

Synthesis

Cyclobenzaprine, N,N-dimethyl-3-(dibenzo[a,d]cyclohepten-5-ylidene) propylamine (15.3.9), is synthesized by reacting 5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium chloride and subsequent dehydration of the resulting carbinol (15.3.8) in acidic conditions into cyclobenzaprine (15.3.9).

CYCLOBENZAPRINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CYCLOBENZAPRINE HCL Suppliers

Canada 1 China 39 Europe 2 India 10 Italy 1 Spain 1 United Kingdom 4 United States 12 Global 70

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Suzhou Kaiyuan Minsheng Sci&Tech Corp. Ltd.

Tel: 0512-62889106
Fax: 0512-62889106
Email: business@minshengpharm.com
Country: China
ProdList: 110
Advantage: 66

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4505
Advantage: 50

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Shanghai Synchem Pharma Co., ltd

Tel: 021-61984905-1 18016477331
Email: synchempharma@aliyun.com
Country: China
ProdList: 6456
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9507
Advantage: 60

Capot Chemical Co.,Ltd.

Tel: 571-85586718 +8613336195806
Fax: +86-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 29797
Advantage: 60

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4393
Advantage: 58

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Tel: +8617731987558
Email: xingjiu@xingjiubiotech.com
Country: China
ProdList: 990
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

Xi'an ZB Biotech Co.,Ltd

Tel
Email: sales03@xazbbio.com
Country: CHINA
ProdList: 722
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551 18958018566;
Fax: 008657185134895
Email: info@afinechem.com
Country: China
ProdList: 15377
Advantage: 58

Jinan Ruisi Pharmaceutical Technology Co., LTD

Tel: 0531-69900633 18340090523
Email: changyuan20@163.com
Country: China
ProdList: 1833
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28180
Advantage: 58

Shanghai Jiegu Biotechnology Co., Ltd.

Tel: 021-51698675
Email: jiejiegroup@126.com
Country: China
ProdList: 4129
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 15093356674;
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29826
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856359 18690052321
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Wuhan Linglingjiu Biotechnology Co., Ltd

Tel: 15623309010
Email: 1287744812@qq.com
Country: China
ProdList: 1657
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31163
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3015
Advantage: 58

Shangqiu City construction union new energy technology Co., LTD

Tel: 18238092829 18238092829
Email: 393581005@qq.com
Country: China
ProdList: 1251
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21689
Advantage: 55

Shenzhen Nexconn Pharmatechs Ltd

Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Country: China
ProdList: 10248
Advantage: 58

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43348
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 50000
Advantage: 58

Shaanxi Didu New Materials Co. Ltd

Tel: +86-89586680 +86-13289823923
Email: 1026@dideu.com
Country: China
ProdList: 9020
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178 +86-85511178
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35453
Advantage: 58

Henan Aochuang Chemical Co.,Ltd.

Tel: +86-0371-63689365 +8618638391208
Email: sales@aochuangchem.com
Country: China
ProdList: 9425
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6921
Advantage: 58

Shenzhen Wanyida Technology Co., Ltd.

Tel: --
Fax: --
Email: 2850183207@qq.com
Country: CHINA
ProdList: 19
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

More

Less

View Lastest Price from CYCLOBENZAPRINE HCL manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: CYCLOBENZAPRINE HCL 303-53-7
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 500MT/month
Release date: 2021-12-20

Career Henan Chemical Co

Product: CYCLOBENZAPRINE HCL 303-53-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

303-53-7, CYCLOBENZAPRINE HCLRelated Search:

Paroxetine Gabapentin Cycloheptatriene PROTRIPTYLINE CYCLOBENZAPRINE HCL Cyclobenzaprine-d3 N-Oxide Benzaprinoxide Cyproheptadine Cyclobenzaprine N-Oxide Cyproheptadine hydrochloride sesquihydrate CYCLOBENZAPRINE HCL

CYCLOBENZAPRINE

CYCLOBENZAPRINE HCL

10,11-dehydroamitriptyline

1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

3-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamin

3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine

5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene

5H-Dibenzo(a,d)cycloheptene-delta<sup>5</sup>,gamma-propylamine, N,N-dimethyl-

Cyclobenzaprine (base and/or unspecified salts)

Cyclobenzaprine base

3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-diMethylpropan-1-aMine

Cyclobenzaprine Impurity 1

9715r.p.

d)cycloheptene-delta(sup5),gamma-propylamine,n,n-dimethyl-5h-dibenzo(

mk130

MK-130

n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5),gamma-propylamine

N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta<sup>5</sup>,gamma-propylamine

Proeptatriene

proheptatrien

Proheptatriene

Ro-4-1577

ro4-1577

RP-9715

Nortriptyline Impurity 5 (Nortriptyline EP Impurity E)

CYCLOBENZAPRINE HCL USP/EP/BP

Cyclobenzaprine (1.0 mg/mL in Methanol)

RSYY（Avanafil)-49

3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine (cyclobenzaprine)

b.3-(5h-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine(cyclobenzaprine),

303-53-7

C20H21N