CYCLOBENZAPRINE HCL

Product Name: CYCLOBENZAPRINE HCL
CAS No.: 303-53-7
Chemical Name: CYCLOBENZAPRINE HCL
Synonyms: CYCLOBENZAPRINE;mk130;MK-130;RP-9715;9715r.p.;ro4-1577;Ro-4-1577;Proeptatriene;proheptatrien;Proheptatriene
CBNumber: CB1116384
Molecular Formula: C20H21N
Formula Weight: 275.39
MOL File: 303-53-7.mol

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CYCLOBENZAPRINE HCL Property

Boiling point:: bp1 175-180°
Density: 0.9504 (rough estimate)
refractive index: 1.7500 (estimate)
pka: pKa 8.47 (Uncertain)
BCS Class: 1
NIST Chemistry Reference: Cyclobenzaprine(303-53-7)

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Safety

Hazardous Substances Data: 303-53-7(Hazardous Substances Data)
Toxicity: LD50 oral in mouse: 250mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: KIT7835
Product name: Cyclobenzaprine(1.0mg/mLinMethanol)
Packaging: 5x1ml
Price: $105
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009177
Product name: CYCLOBENZAPRINE
Purity: 95.00%
Packaging: 5MG
Price: $497.28
Updated: 2021/12/16

AHH

Product number: MT-49581
Product name: Cyclobenzaprine
Purity: 98%
Packaging: 0.05g
Price: $410
Updated: 2021/12/16

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CYCLOBENZAPRINE HCL Chemical Properties,Usage,Production

Description

Cyclobenzaprine is structurally similar to tricyclic antidepressants. It acts at the brain stem level.

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

It is used as an adjuvant agent for relieving muscle spasms associated with severe diseased conditions of the muscle. A synonym of this drug is flexeril.

Uses

Relaxant (muscle).

Definition

ChEBI: 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its h drochloride salt in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

Synthesis

Cyclobenzaprine, N,N-dimethyl-3-(dibenzo[a,d]cyclohepten-5-ylidene) propylamine (15.3.9), is synthesized by reacting 5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium chloride and subsequent dehydration of the resulting carbinol (15.3.8) in acidic conditions into cyclobenzaprine (15.3.9).

CYCLOBENZAPRINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLOBENZAPRINE HCL Suppliers

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View Lastest Price from CYCLOBENZAPRINE HCL manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: CYCLOBENZAPRINE HCL 303-53-7
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 500MT/month
Release date: 2021-12-20

Career Henan Chemical Co

Product: CYCLOBENZAPRINE HCL 303-53-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

303-53-7, CYCLOBENZAPRINE HCLRelated Search:

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CYCLOBENZAPRINE

CYCLOBENZAPRINE HCL

10,11-dehydroamitriptyline

1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

3-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamin

3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine

5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene

5H-Dibenzo(a,d)cycloheptene-delta<sup>5</sup>,gamma-propylamine, N,N-dimethyl-

Cyclobenzaprine (base and/or unspecified salts)

Cyclobenzaprine base

3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-diMethylpropan-1-aMine

Cyclobenzaprine Impurity 1

9715r.p.

d)cycloheptene-delta(sup5),gamma-propylamine,n,n-dimethyl-5h-dibenzo(

mk130

MK-130

n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5),gamma-propylamine

N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta<sup>5</sup>,gamma-propylamine

Proeptatriene

proheptatrien

Proheptatriene

Ro-4-1577

ro4-1577

RP-9715

Nortriptyline Impurity 5 (Nortriptyline EP Impurity E)

CYCLOBENZAPRINE HCL USP/EP/BP

Cyclobenzaprine (1.0 mg/mL in Methanol)

RSYY（Avanafil)-49

3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine (cyclobenzaprine)

b.3-(5h-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine(cyclobenzaprine),

303-53-7

C20H21N