4-Hydroxy Valsartan, Mixture of Diastereomers

Product Name: 4-Hydroxy Valsartan, Mixture of Diastereomers
CAS No.: 188259-69-0
Chemical Name: 4-Hydroxy Valsartan, Mixture of Diastereomers
Synonyms: CGP 71580;Valsartan 4-Hydroxy;Valsartan Impurity I;Valsartan related compound I;Valsartan 4-Hydroxy Impurity;(2S)-2-(N-((2'-(1H-tetrazol-5-yl);Valsartan 4-Hydroxy Valeryl Analog;4-Hydroxy Valsartan, Mixture of Diastereomers;N-(4-Hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl) [1,1'-biphenyl]-4-yl]Methyl]-;N-(4-Hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
CBNumber: CB11175870
Molecular Formula: C24H29N5O4
Formula Weight: 451.52
MOL File: 188259-69-0.mol

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4-Hydroxy Valsartan, Mixture of Diastereomers Property

Melting point:: 130-132°C
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 188259-69-0

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27849
Product name: 4-hydroxy Valsartan
Packaging: 2.5mg
Price: $396
Updated: 2024/03/01

TRC

Product number: H995000
Product name: 4-HydroxyValsartan(MixtureofDiastereomers)
Packaging: 2.5mg
Price: $180
Updated: 2021/12/16

TRC

Product number: H995000
Product name: 4-HydroxyValsartan(MixtureofDiastereomers)
Packaging: 25mg
Price: $1390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000265
Product name: 4-HYDROXY VALSARTAN
Purity: 95.00%
Packaging: 2.5MG
Price: $952.88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000265
Product name: 4-HYDROXY VALSARTAN
Purity: 95.00%
Packaging: 25MG
Price: $2243.59
Updated: 2021/12/16

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4-Hydroxy Valsartan, Mixture of Diastereomers Chemical Properties,Usage,Production

Description

4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT₁) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.

Chemical Properties

White Solid

Uses

A nonpeptide angiotensin II AT1-receptor antagonist.

Definition

ChEBI: 4-Hydroxyvalsartan is a valine derivative.

Synthesis

8.64 g of benzyl (S)-2-[(2-cyanobiphenyl-4-ylmethyl)-(4-oxo-pentanoyl)-amino]-3-methyl-butanoate in 20 ml of xylene and 12.71 g of Tributyltinazid (Aldrich) were refluxed for 28 hours. The mixture was treated with 0.5N aqueous sodium hydroxide, the aqueous phase was washed with ether and the ether phase was extracted once with water. The combined aqueous phases were acidified with concentrated aqueous hydrochloric acid, extracted with dichloromethane, washed with water, suspended in activated carbon, filtered, dried with sodium sulfate, concentrated and dried under vacuum. The product (S)-3-methyl-2-{(4-oxo-pentanoyl)-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butanoic acid benzyl ester was obtained as a brown foam. 7.9 g of benzyl (S)-3-methyl-2-{(4-oxo-pentanoyl)-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butanoate in 160 ml of tetrahydrofuran was hydrogenated in the presence of 1.5 g of lapped palladium-carbon (10%) at atmospheric pressure and room temperature until saturation was reached. The mixture was filtered and concentrated in vacuo to afford (S)-3-methyl-2-{(4-oxo-pentanoyl)-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butanoic acid as almost white foam

References

[1] VICTOR L SEREBRUANY. Effects of valsartan and valeryl 4-hydroxy valsartan on human platelets: a possible additional mechanism for clinical benefits.[J]. Journal of Cardiovascular Pharmacology, 2004, 43 5: 677-684. DOI: 10.1097/00005344-200405000-00010

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View Lastest Price from 4-Hydroxy Valsartan, Mixture of Diastereomers manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Hydroxy Valsartan, Mixture of Diastereomers 188259-69-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Hydroxy Valsartan 188259-69-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 60 tons
Release date: 2019-12-30

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Hydroxy Valsartan (Mixture of DiastereoMers) 188259-69-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-15

188259-69-0, 4-Hydroxy Valsartan, Mixture of DiastereomersRelated Search:

Valsartan Isoleucine Valsartan Valsartan Desvaleryl Impurity Valsartan n-Propyl Valsartan Impurity 1 L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE Valsartan Impurity 10 Valsartan Impurity 5 Valsartan Methyl Ester Pentanamide, N-(diazirino[1,3-f]phenanthridin-4-ylmethyl)-N-(2-methylpropyl)- Valsartan Impurity 12 Valsartan Impurity 3 ethyl N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-N-pentanoyl-L-valinate 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE Valsartan Related Compound A Valsartan cyano analog methyl ester Valsartan Impurity 26 L-Valine, N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-N-(1-oxopropyl)-, methyl ester

(S)-2-{(4(R,S)-Hydroxy-pentanoyl)-[2(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amino}-3-methyl-butyric Acid

4-Hydroxy Valsartan, Mixture of Diastereomers

CGP 71580

N-(4-Hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine

Valsartan 4-Hydroxy

(S)-N-(4-Hydroxy-1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-valine

(2S)-2-(N-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-hydroxypentanamido)-3-methylbutanoic acid

Valsartan 4-Hydroxy Impurity

Valsartan 4-Hydroxy Valeryl Analog

N-(4-Hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl) [1,1'-biphenyl]-4-yl]Methyl]-

Valsartan related compound I

(2S)-2-[4-hydroxypentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-3-methylbutanoic acid

(2S)-2-(N-((2'-(1H-tetrazol-5-yl)

L-Valine, N-(4-hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

4-hydroxy valsartanQ: What is 4-hydroxy valsartan Q: What is the CAS Number of 4-hydroxy valsartan Q: What is the storage condition of 4-hydroxy valsartan Q: What are the applications of 4-hydroxy valsartan

Valsartan Impurity I

L-Valine, N-(4-hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

188259-69-0

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