Dihydrodaidzein

Product Name: Dihydrodaidzein
CAS No.: 17238-05-0
Chemical Name: Dihydrodaidzein
Synonyms: Dihydrodaidzein>DIHYDRODAIDZEIN hplc;Dihydrodaidzein standard;7-hydroxy-3-(4-hydroxyphenyl)chroman-4-one;7-Hydroxy-3-(4-hydroxyphenyl)-4-chromanone;7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one;inhibit,Endogenous Metabolite,Dihydrodaidzein,Inhibitor;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-3-(4-hydroxyphenyl)-;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one,99%e.e.
CBNumber: CB11176286
Molecular Formula: C15H12O4
Formula Weight: 256.25
MOL File: 17238-05-0.mol

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Dihydrodaidzein Property

Melting point:: 250-251°C
Boiling point:: 529.5±50.0 °C(Predicted)
Density: 1.386±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: ≤0.1mg/ml in ethanol;30mg/ml in DMSO;10mg/ml in dimethyl formamide
pka: 7.71±0.40(Predicted)
form: powder to crystal
color: Light orange to Yellow to Green
λmax: 313nm(EtOH aq.)(lit.)
CAS DataBase Reference: 17238-05-0

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00944
Product name: Dihydrodaidzein
Purity: ≥95%
Packaging: 10MG
Price: $176
Updated: 2024/03/01

Sigma-Aldrich

Product number: SMB00944
Product name: Dihydrodaidzein
Purity: ≥95%
Packaging: 50MG
Price: $410
Updated: 2024/03/01

TCI Chemical

Product number: D4239
Product name: Dihydrodaidzein
Purity: >93.0%(HPLC)
Packaging: 25mg
Price: $313
Updated: 2024/03/01

Cayman Chemical

Product number: 17423
Product name: Dihydrodaidzein
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17423
Product name: Dihydrodaidzein
Purity: ≥98%
Packaging: 10mg
Price: $70
Updated: 2024/03/01

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Dihydrodaidzein Chemical Properties,Usage,Production

Chemical Properties

Light Beige Needles

Uses

A metabolite of Daidzein.

Uses

Daidzein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes. Dihydrodaidzein is an active, estrogenic metabolite of daidzein. It has vasodilatory action on rat isolated aortic rings at 1 μg/ml. It stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations. Dihydrodaidzein is produced by the metabolism of daidzein in colonic bacteria and may be further metabolized to various bioactive compounds, including equol .

Definition

ChEBI: A hydroxyisoflavanone that is isoflavanone carrying two hydroxy substituents located at positions 4' and 7.

Biological Activity

dihydrodaidzein, an active, estrogenic metabolite of daidzein in colonic bacteria, probably is further metabolized to various bioactive compounds including equol. as an estrogen receptor agonist, dihydrodaidzein, at micromolar concentrations, activates the estrogen receptor-dependent growth of breast cancer cells. daidzein, an isoflavonoid phytoestrogenic compound, is found in soybeans, clover, kudzu, and other legumes.

in vitro

prostatic fluid and plasma concentrations of dihydrodaidzein were sufficient to block the growth of benign human prostatic epithelial cells (prec). dihydrodaidzein showed a significant inhibitory effect on the growth of prostate cancer cell line lncap. additionally, dihydrodaidzein slightly triggered the apoptosis of prec. in addition to affecting apoptosis, dihydrodaidzein decreased proliferation, which was associated with the changes in cell cycle distribution and caspase 3 activation [1].

in vivo

male c57b1/6 wild type mice were administered orally with dihydrodaidzein at a dose of 25 mg/kg/day for 4 weeks. compared to the control groups, the neointima of mice treated with dihydrodaidzein was thickened. in dihydrodaidzein-treated mice, the intimal thickness in the non-injured right iliac artery was not altered. moreover, neointimal proliferation was selectively blocked by dihydrodaidzein via suppressing the migration and proliferation of vascular smooth muscle cell and dampening the endothelial apoptosis [2].

References

[1]. hedlund, t., bokhoven, a., johannes, w., nordeen, s., & ogden, l. prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. the prostate. 2006; 66(5): 557-566.
[2]. shen, j., white, m., husband, a., hambly, b., & bao, s. phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. european journal of pharmacology. 2006; 548(1-3): 123-128.

Dihydrodaidzein Preparation Products And Raw materials

Raw materials

Preparation Products

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Dihydrodaidzein Suppliers

Americas 1 Canada 1 China 73 Europe 1 Germany 1 India 3 Japan 1 Switzerland 1 United Kingdom 5 United States 11 USA 1 Global 99

EMMX Biotechnology LLC

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View Lastest Price from Dihydrodaidzein manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Dihydrodaidzein 17238-05-0
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-01-02

17238-05-0, DihydrodaidzeinRelated Search:

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DIHYDRODAIDZEIN hplc

2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one,99%e.e.

7-hydroxy-3-(4-hydroxyphenyl)chroman-4-one

7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one

Dihydrodaidzein&gt

4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-3-(4-hydroxyphenyl)-

7-Hydroxy-3-(4-hydroxyphenyl)-4-chromanone

inhibit,Endogenous Metabolite,Dihydrodaidzein,Inhibitor

Dihydrodaidzein standard

17238-05-0

inhibitor

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Iso-Flavones

Various Metabolites and Impurities