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Lapatinib Ditosylate

Product Name
Lapatinib Ditosylate
CAS No.
388082-77-7
Chemical Name
Lapatinib Ditosylate
Synonyms
GW-572016F;Tykerb Ditosylat;apatinib DitosyL;Tykerb Ditosylate;Tykerb(lapatinib);Lapatinib Tosylate;GW-572016 ditosylate;GW 572016 ditosylate;Lapatinib ditosylate;Lapatinib ditasylate
CBNumber
CB11176387
Molecular Formula
C36H34ClFN4O7S2
Formula Weight
753.26
MOL File
388082-77-7.mol
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Lapatinib Ditosylate Property

Melting point:
240-2420C
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥24.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
color 
Light yellow to yellow
Water Solubility 
Water: Insoluble
CAS DataBase Reference
388082-77-7
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Safety

Safety Statements 
24/25
HS Code 
29420000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
L175800
Product name
LapatinibDitosylate
Packaging
25mg
Price
$65
Updated
2021/12/16
TRC
Product number
L175800
Product name
LapatinibDitosylate
Packaging
100mg
Price
$120
Updated
2021/12/16
TRC
Product number
L175800
Product name
LapatinibDitosylate
Packaging
1g
Price
$495
Updated
2021/12/16
ChemScene
Product number
CS-0831
Product name
Lapatinibditosylate
Purity
99.95%
Packaging
5g
Price
$540
Updated
2021/12/16
ChemScene
Product number
CS-0831
Product name
Lapatinibditosylate
Purity
99.95%
Packaging
50mg
Price
$60
Updated
2021/12/16
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Lapatinib Ditosylate Chemical Properties,Usage,Production

Description

Lapatinib, an ErB-1 and ErB-2 dual kinase inhibitor, was launched for the treatment of advanced or metastatic HER2 (ErbB2) positive breast cancer in women who have received prior therapy. The drug was discovered and developed by GlaxoSmithKline and is also currently being evaluated for several additional cancer indications.

Chemical Properties

Yellow Solid

Uses

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Uses

Lapatinib Ditosylate is a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.

Synthesis

The synthesis started with Williamson ether synthesis between 2-chloro-4-nitrophenol (58) and 3-fluorobenzyl bromide to give ether 59 in the following scheme; however, no specific yields were provided. Reduction of the nitro group of compound 59 by catalytic hydrogenation over Pt/C and subsequent condensation of the resulting aniline with 4-chloro-6-iodoquinazoline (61) in refluxing i-PrOH afforded compound 62. 4-Chloro-6-iodoquinazoline (61) was prepared by reacting 6-iodoquinazolin- 4(3H)-one (60) with POCl3 in the presence of triethylamine. Compound 62 was subjected to Stille coupling with 5- dioxolanyl-2-(tributylstannyl)furan (63) in the presence of PdCl2(PPh3)2 to give 64. Acidic hydrolysis of acetal 64 using HCl in THF/H2O provided the corresponding aldehyde which was further subjected to reductive amination with 2-(methan-esulfonyl)ethylamine in the presence of sodium triacetoxyborohydride to yield lapatinib. Lapatinib was treated with ptoluenesulfonic acid solution to give lapatinib ditosylate (IX).

Lapatinib Ditosylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Lapatinib Ditosylate Suppliers

Jinan Sunshine Pharmaceutical Co.,Ltd.
Tel
531-82812892
Fax
0531-82812892
Email
sunshinepharm0531@163.com
Country
China
ProdList
68
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
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View Lastest Price from Lapatinib Ditosylate manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Lapatinib Ditosylate 388082-77-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-24
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
Product
Lapatinib ditosylate 388082-77-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.9% HPLC
Supply Ability
10000
Release date
2023-09-07
Hebei Mojin Biotechnology Co., Ltd
Product
Lapatinib Ditosylate 388082-77-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-20

388082-77-7, Lapatinib DitosylateRelated Search:


  • TYKERB DITOSYLATE; GW 572016 DITOSYLATE; GW-572016 DITOSYLATE
  • GW 572016 DITOSYLATE;GW-572016 DITOSYLATE
  • Lapatinib ditosylate
  • 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, 4-Methylbenzenesulfonate (1:2)
  • Lapatinib Ditosylate (Tykerb)
  • GW 572016 ditosylate
  • GW-572016 ditosylate
  • GW-572016F
  • Tykerb Ditosylat
  • GW-572016F Ditosylate
  • N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate) Ditosylate
  • Tykerb Ditosylate
  • N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(Methylsulfonyl)ethyl]aMino}Methyl)-2-furyl]-4-quinazolinaMine 4-Methylbenzenesulfonate (1:2)
  • Lapatinib ditasylate
  • N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(Methylsulfonyl)ethyl)aMino)Methyl)furan-2-yl)quinazolin-4-aMine bis(4-Methylbenzenesulfonate)
  • Lapatinib (GW-572016) Ditosylate
  • N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate
  • Tykerb(lapatinib)
  • N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylBenzenesulfonate)
  • apatinib DitosyL
  • Lapatinib Tosylate
  • Lapatinib Ditosylate USP/EP/BP
  • Lapatinib ditosylate anhydrous
  • Lapatinib Ditosylate (GW-572016, Tykerb)
  • dipyrido[3,2-a:2',7'-c]phenazine
  • N-3-Chloro-4-(3-fluorophenyl)methoxyphenyl-6-5-2-(methylsulfonyl)ethylaminomethyl-furan-2-yl-4-amino-quinazoline tosylate (1:2)
  • 388082-77-7
  • C43H42ClFN4O10S3
  • Inhibitors
  • Final material
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors