Lapatinib Ditosylate

Product Name: Lapatinib Ditosylate
CAS No.: 388082-77-7
Chemical Name: Lapatinib Ditosylate
Synonyms: GW-572016F;Tykerb Ditosylat;apatinib DitosyL;Tykerb Ditosylate;Tykerb(lapatinib);Lapatinib Tosylate;GW-572016 ditosylate;GW 572016 ditosylate;Lapatinib ditosylate;Lapatinib ditasylate
CBNumber: CB11176387
Molecular Formula: C36H34ClFN4O7S2
Formula Weight: 753.26
MOL File: 388082-77-7.mol

More

Less

Lapatinib Ditosylate Property

Melting point:: 240-2420C
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: ≥24.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: solid
color: Light yellow to yellow
Water Solubility: Water: Insoluble
CAS DataBase Reference: 388082-77-7

More

Less

Safety

Safety Statements: 24/25
HS Code: 29420000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: L175800
Product name: LapatinibDitosylate
Packaging: 25mg
Price: $65
Updated: 2021/12/16

TRC

Product number: L175800
Product name: LapatinibDitosylate
Packaging: 100mg
Price: $120
Updated: 2021/12/16

TRC

Product number: L175800
Product name: LapatinibDitosylate
Packaging: 1g
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-0831
Product name: Lapatinibditosylate
Purity: 99.95%
Packaging: 5g
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-0831
Product name: Lapatinibditosylate
Purity: 99.95%
Packaging: 50mg
Price: $60
Updated: 2021/12/16

More

Less

Lapatinib Ditosylate Chemical Properties,Usage,Production

Description

Lapatinib, an ErB-1 and ErB-2 dual kinase inhibitor, was launched for the treatment of advanced or metastatic HER2 (ErbB2) positive breast cancer in women who have received prior therapy. The drug was discovered and developed by GlaxoSmithKline and is also currently being evaluated for several additional cancer indications.

Chemical Properties

Yellow Solid

Uses

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Uses

Lapatinib Ditosylate is a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.

Synthesis

The synthesis started with Williamson ether synthesis between 2-chloro-4-nitrophenol (58) and 3-fluorobenzyl bromide to give ether 59 in the following scheme; however, no specific yields were provided. Reduction of the nitro group of compound 59 by catalytic hydrogenation over Pt/C and subsequent condensation of the resulting aniline with 4-chloro-6-iodoquinazoline (61) in refluxing i-PrOH afforded compound 62. 4-Chloro-6-iodoquinazoline (61) was prepared by reacting 6-iodoquinazolin- 4(3H)-one (60) with POCl3 in the presence of triethylamine. Compound 62 was subjected to Stille coupling with 5- dioxolanyl-2-(tributylstannyl)furan (63) in the presence of PdCl2(PPh3)2 to give 64. Acidic hydrolysis of acetal 64 using HCl in THF/H2O provided the corresponding aldehyde which was further subjected to reductive amination with 2-(methan-esulfonyl)ethylamine in the presence of sodium triacetoxyborohydride to yield lapatinib. Lapatinib was treated with ptoluenesulfonic acid solution to give lapatinib ditosylate (IX).

Lapatinib Ditosylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Lapatinib Ditosylate Suppliers

Canada 1 China 189 India 13 United States 20 Global 223

Jinan Sunshine Pharmaceutical Co.,Ltd.

Tel: 531-82812892
Fax: 0531-82812892
Email: sunshinepharm0531@163.com
Country: China
ProdList: 68
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

More

Less

View Lastest Price from Lapatinib Ditosylate manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Lapatinib ditosylate 388082-77-7
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99% HPLC
Supply Ability: 1000kg
Release date: 2024-11-19

Hebei Weibang Biotechnology Co., Ltd

Product: Lapatinib Ditosylate 388082-77-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-24

SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.

Product: Lapatinib ditosylate 388082-77-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.9% HPLC
Supply Ability: 10000
Release date: 2023-09-07

388082-77-7, Lapatinib DitosylateRelated Search:

Lapatinib IMpurity 10 Lapatinib Sorafenib tosylate Gefitinib Erlotinib hydrochloride Crizotinib Ruxolitinib Olaparib Lapatinib impurity L Lapatinib 2-Fluoro Impurity Lapatinib 4-Fluoro Impurity N-De[2-(Methylsulfonyl)ethyl] Lapatinib Lapatinib iMpurity Lapatinib Impurity 16 3-Chloro-4-(3-fluorobenzyloxy)aniline Lapatinib Lapatinib Ditosylate 2-AMINOETHANETHIOL P-TOLUENESULFONATE

TYKERB DITOSYLATE; GW 572016 DITOSYLATE; GW-572016 DITOSYLATE

GW 572016 DITOSYLATE;GW-572016 DITOSYLATE

Lapatinib ditosylate

4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, 4-Methylbenzenesulfonate (1:2)

Lapatinib Ditosylate (Tykerb)

GW 572016 ditosylate

GW-572016 ditosylate

GW-572016F

Tykerb Ditosylat

GW-572016F Ditosylate

N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate) Ditosylate

Tykerb Ditosylate

N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(Methylsulfonyl)ethyl]aMino}Methyl)-2-furyl]-4-quinazolinaMine 4-Methylbenzenesulfonate (1:2)

Lapatinib ditasylate

N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(Methylsulfonyl)ethyl)aMino)Methyl)furan-2-yl)quinazolin-4-aMine bis(4-Methylbenzenesulfonate)

Lapatinib (GW-572016) Ditosylate

N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate

Tykerb(lapatinib)

N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylBenzenesulfonate)

apatinib DitosyL

Lapatinib Tosylate

Lapatinib Ditosylate USP/EP/BP

Lapatinib ditosylate anhydrous

Lapatinib Ditosylate (GW-572016, Tykerb)

dipyrido[3,2-a:2',7'-c]phenazine

N-3-Chloro-4-(3-fluorophenyl)methoxyphenyl-6-5-2-(methylsulfonyl)ethylaminomethyl-furan-2-yl-4-amino-quinazoline tosylate (1:2)

388082-77-7

C43H42ClFN4O10S3

Inhibitors

Final material

Intermediates & Fine Chemicals

Pharmaceuticals

Tyrosine Kinase Inhibitors