Lapatinib Ditosylate
- Product Name
- Lapatinib Ditosylate
- CAS No.
- 388082-77-7
- Chemical Name
- Lapatinib Ditosylate
- Synonyms
- GW-572016F;Tykerb Ditosylat;apatinib DitosyL;Tykerb Ditosylate;Tykerb(lapatinib);Lapatinib Tosylate;GW-572016 ditosylate;GW 572016 ditosylate;Lapatinib ditosylate;Lapatinib ditasylate
- CBNumber
- CB11176387
- Molecular Formula
- C36H34ClFN4O7S2
- Formula Weight
- 753.26
- MOL File
- 388082-77-7.mol
Lapatinib Ditosylate Property
- Melting point:
- 240-2420C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- ≥24.3 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- color
- Light yellow to yellow
- Water Solubility
- Water: Insoluble
- CAS DataBase Reference
- 388082-77-7
Safety
- Safety Statements
- 24/25
- HS Code
- 29420000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L175800
- Product name
- LapatinibDitosylate
- Packaging
- 25mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- L175800
- Product name
- LapatinibDitosylate
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- L175800
- Product name
- LapatinibDitosylate
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- CS-0831
- Product name
- Lapatinibditosylate
- Purity
- 99.95%
- Packaging
- 5g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CS-0831
- Product name
- Lapatinibditosylate
- Purity
- 99.95%
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
Lapatinib Ditosylate Chemical Properties,Usage,Production
Description
Lapatinib, an ErB-1 and ErB-2 dual kinase inhibitor, was launched for the treatment of advanced or metastatic HER2 (ErbB2) positive breast cancer in women who have received prior therapy. The drug was discovered and developed by GlaxoSmithKline and is also currently being evaluated for several additional cancer indications.
Chemical Properties
Yellow Solid
Uses
Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
Uses
Lapatinib Ditosylate is a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.
Synthesis
The synthesis started with Williamson ether synthesis between 2-chloro-4-nitrophenol (58) and 3-fluorobenzyl bromide to give ether 59 in the following scheme; however, no specific yields were provided. Reduction of the nitro group of compound 59 by catalytic hydrogenation over Pt/C and subsequent condensation of the resulting aniline with 4-chloro-6-iodoquinazoline (61) in refluxing i-PrOH afforded compound 62. 4-Chloro-6-iodoquinazoline (61) was prepared by reacting 6-iodoquinazolin- 4(3H)-one (60) with POCl3 in the presence of triethylamine. Compound 62 was subjected to Stille coupling with 5- dioxolanyl-2-(tributylstannyl)furan (63) in the presence of PdCl2(PPh3)2 to give 64. Acidic hydrolysis of acetal 64 using HCl in THF/H2O provided the corresponding aldehyde which was further subjected to reductive amination with 2-(methan-esulfonyl)ethylamine in the presence of sodium triacetoxyborohydride to yield lapatinib. Lapatinib was treated with ptoluenesulfonic acid solution to give lapatinib ditosylate (IX).
Lapatinib Ditosylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Lapatinib Ditosylate manufacturers
- Product
- Lapatinib Ditosylate 388082-77-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-24
- Product
- Lapatinib ditosylate 388082-77-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9% HPLC
- Supply Ability
- 10000
- Release date
- 2023-09-07
- Product
- Lapatinib Ditosylate 388082-77-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-20