3-Bromo-5-chlorophenol
Uses- Product Name
- 3-Bromo-5-chlorophenol
- CAS No.
- 56962-04-0
- Chemical Name
- 3-Bromo-5-chlorophenol
- Synonyms
- 3-BroMo-chlorophenol;3-BROMO-5-CHLOROPHENOL;Phenol, 3-bromo-5-chloro-;3-BroMo-5-chlorophenol, 97+%
- CBNumber
- CB11177445
- Molecular Formula
- C6H4BrClO
- Formula Weight
- 207.45
- MOL File
- 56962-04-0.mol
3-Bromo-5-chlorophenol Property
- Melting point:
- 66-70℃
- Boiling point:
- 256°C (rough estimate)
- Density
- 1.6027 (rough estimate)
- vapor pressure
- 0.004-0.084Pa at 20-50℃
- refractive index
- 1.5730 (estimate)
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 8.04±0.10(Predicted)
- form
- Solid
- Appearance
- White to off-white Solid
- LogP
- 3.2 at 25℃ and pH2
- Surface tension
- 54.7mN/m at 1g/L and 20℃
- CAS DataBase Reference
- 56962-04-0
Safety
- HS Code
- 2908190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B684153
- Product name
- 3-Bromo-5-chlorophenol
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 077970
- Product name
- 3-Bromo-5-chlorophenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 077970
- Product name
- 3-Bromo-5-chlorophenol
- Purity
- 97%
- Packaging
- 5g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- FB66909
- Product name
- 3-Bromo-5-chlorophenol
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W7052
- Product name
- 3-Bromo-5-chlorophenol
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
3-Bromo-5-chlorophenol Chemical Properties,Usage,Production
Uses
3-Chloro-5-bromophenol is an important pharmaceutical intermediate that can be used in the preparation of a variety of pharmaceutical products.
Synthesis
108-37-2
56962-04-0
General procedure for the synthesis of 3-bromo-5-chlorophenol from m-chlorobromobenzene: In an argon-purged flask, (1,5-cyclooctadiene)(methoxy)iridium(I) dimer (84 mg, 0.13 mmol), 4,4'-di-tert-butyl-2,2'-bipyridine (69 mg, 0.26 mmol), and bis(pinacolate)diboron (1.29 g, 5.11 mmol) were added. 5.11 mmol), followed by hexane (26 mL) and 1-bromo-3-chlorobenzene (1 mL, 8.51 mmol) sequentially. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and redissolved in acetone (26 mL) followed by addition of an aqueous (26 mL) solution of Oxone (5.23 g, 8.51 mmol) [Note: exothermic phenomena were observed during the reaction].After 10 min, the reaction mixture was diluted with dichloromethane. The organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane. The organic phases were combined, washed with brine, dried and concentrated in vacuum to give 3-bromo-5-chlorophenol (1.43 g, 81% yield).LCMS (Method 3): retention time 3.74 min, mass-to-charge ratio m/z 205,207 [M-H+].
References
[1] Patent: US2014/364412, 2014, A1. Location in patent: Paragraph 0683; 0684
[2] Patent: WO2014/195402, 2014, A1. Location in patent: Page/Page column 217
[3] Patent: WO2009/115515, 2009, A1. Location in patent: Page/Page column 44-45
[4] Journal of the American Chemical Society, 2003, vol. 125, # 26, p. 7792 - 7793
[5] Synthesis, 2011, # 6, p. 857 - 859
3-Bromo-5-chlorophenol Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Bromo-5-chlorophenol manufacturers
- Product
- 3-Bromo-5-chlorophenol 56962-04-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-23