1-BROMO-3-CHLORO-5-METHOXYBENZENE
- Product Name
- 1-BROMO-3-CHLORO-5-METHOXYBENZENE
- CAS No.
- 174913-12-3
- Chemical Name
- 1-BROMO-3-CHLORO-5-METHOXYBENZENE
- Synonyms
- 3-Bromo-5-chloroanisole;Phloroglucinol Impurity 34;Phloroglucinol Impurity 56;3-chloro-5-bromobenzyl ether;1-BROMO-3-CHLORO-5-METHOXYBENZENE;Benzene, 1-bromo-3-chloro-5-methoxy-;3-bromo-5-chlorotrifluoromethoxybenzene;1-BROMO-3-CHLORO-5-METHOXYBENZENE ISO 9001：2015 REACH
- CBNumber
- CB32455168
- Molecular Formula
- C7H6BrClO
- Formula Weight
- 221.48
- MOL File
- 174913-12-3.mol
1-BROMO-3-CHLORO-5-METHOXYBENZENE Property
- Boiling point:
- 236.5±20.0 °C(Predicted)
- Density
- 1.564±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light brown to off-white Solid
- InChI
- InChI=1S/C7H6BrClO/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,1H3
- InChIKey
- VOGGSKPTKSAXHR-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC(OC)=CC(Cl)=C1
Safety
- HS Code
- 2909303890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683568
- Product name
- 3-Bromo-5-chloroanisole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B683568
- Product name
- 3-Bromo-5-chloroanisole
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W3821
- Product name
- 1-Bromo-3-chloro-5-methoxybenzene
- Packaging
- 25g
- Price
- $237
- Updated
- 2021/12/16
- Product number
- OR400559
- Product name
- 3-Bromo-5-chloroanisole
- Packaging
- 25g
- Price
- $269
- Updated
- 2021/12/16
- Product number
- 076555
- Product name
- 1-Bromo-3-chloro-5-methoxybenzene
- Purity
- 95+%
- Packaging
- 25g
- Price
- $149
- Updated
- 2021/12/16
1-BROMO-3-CHLORO-5-METHOXYBENZENE Chemical Properties,Usage,Production
Uses
1-Bromo-3-chloro-5-methoxybenzene is a commonly used organobenzene compound whose bromine or chlorine atoms on the benzene ring structure can be replaced by other halogenated atoms for the synthesis of other halogenated methoxybenzene derivatives. It can also be used to synthesise 3-Bromo-5-chlorophenol and its derivatives.
Synthesis
1-Bromo-3-chloro-5-methoxybenzene is prepared by the reaction of 1-bromo-3-chloro-5-fluoro-benzene and Sodium methanolate. The specific synthesis steps are as follows:
A solution of 1-bromo-3-chloro-5-fluoro-benzene (42a, 55 g, 263 mmol) was cooled to 0° C. and treated with a 25percent methanolic sodium methoxide solution (68 mL, 315 mmol) and heated to 40° C. for 3 h. The solution was cooled and partitioned between water (1 L) and a 1:1 mixture of hexane/diethyl ether (3.x.200 mL). The combined extracts were washed with brine (60 mL), dried (Na2SO4), filtered and the solvents evaporated in vacuo to afford 42b as an oil (57.3 g, 92percent pure, 238 mmol). The ether 42b (43 g, 173 mmol) was treated with glacial HOAc (150 mL) and 48percent aqueous HBr (100 mL) and heated to 120° C. After 40 h, the volatiles were removed while heated to 80° C. and then cooled to RT. The residue was partitioned between water (100 mL) and DCM (3.x.250 mL). The combined extracts were washed with H2O (50 mL), aqueous NaHCO3solution (2.x.50 mL), brine (50 mL), and (MgSO4). The solvents were removed to afford 23.3 g of 1-Bromo-3-chloro-5-methoxybenzene as a grey solid.
References
[1] Patent: US2006/25462, 2006, A1. Location in patent: Page/Page column 16-17
[2] Patent: WO2015/187089, 2015, A1. Location in patent: Page/Page column 62; 63
[3] Patent: US2007/105872, 2007, A1. Location in patent: Page/Page column 29
[4] Patent: WO2004/31178, 2004, A1. Location in patent: Page 25
[5] Patent: WO2004/29051, 2004, A1. Location in patent: Page 33
1-BROMO-3-CHLORO-5-METHOXYBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BROMO-3-CHLORO-5-METHOXYBENZENE manufacturers
- Product
- 1-Bromo-3-chloro-5-methoxybenzene 174913-12-3
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 1-BROMO-3-CHLORO-5-METHOXYBENZENE 174913-12-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24