ChemicalBook > CAS DataBase List > 1-BROMO-3-CHLORO-5-METHOXYBENZENE

1-BROMO-3-CHLORO-5-METHOXYBENZENE

Product Name: 1-BROMO-3-CHLORO-5-METHOXYBENZENE
CAS No.: 174913-12-3
Chemical Name: 1-BROMO-3-CHLORO-5-METHOXYBENZENE
Synonyms: 3-Bromo-5-chloroanisole;Phloroglucinol Impurity 34;Phloroglucinol Impurity 56;3-chloro-5-bromobenzyl ether;1-BROMO-3-CHLORO-5-METHOXYBENZENE;Benzene, 1-bromo-3-chloro-5-methoxy-;3-bromo-5-chlorotrifluoromethoxybenzene;1-BROMO-3-CHLORO-5-METHOXYBENZENE ISO 9001：2015 REACH
CBNumber: CB32455168
Molecular Formula: C7H6BrClO
Formula Weight: 221.48
MOL File: 174913-12-3.mol

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1-BROMO-3-CHLORO-5-METHOXYBENZENE Property

Boiling point:: 236.5±20.0 °C(Predicted)
Density: 1.564±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: Light brown to off-white Solid
InChI: InChI=1S/C7H6BrClO/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,1H3
InChIKey: VOGGSKPTKSAXHR-UHFFFAOYSA-N
SMILES: C1(Br)=CC(OC)=CC(Cl)=C1

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Safety

HS Code: 2909303890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B683568
Product name: 3-Bromo-5-chloroanisole
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B683568
Product name: 3-Bromo-5-chloroanisole
Packaging: 500mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: W3821
Product name: 1-Bromo-3-chloro-5-methoxybenzene
Packaging: 25g
Price: $237
Updated: 2021/12/16

Apolloscientific

Product number: OR400559
Product name: 3-Bromo-5-chloroanisole
Packaging: 25g
Price: $269
Updated: 2021/12/16

Matrix Scientific

Product number: 076555
Product name: 1-Bromo-3-chloro-5-methoxybenzene
Purity: 95+%
Packaging: 25g
Price: $149
Updated: 2021/12/16

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1-BROMO-3-CHLORO-5-METHOXYBENZENE Chemical Properties,Usage,Production

Uses

1-Bromo-3-chloro-5-methoxybenzene is a commonly used organobenzene compound whose bromine or chlorine atoms on the benzene ring structure can be replaced by other halogenated atoms for the synthesis of other halogenated methoxybenzene derivatives. It can also be used to synthesise 3-Bromo-5-chlorophenol and its derivatives.

Synthesis

1-Bromo-3-chloro-5-methoxybenzene is prepared by the reaction of 1-bromo-3-chloro-5-fluoro-benzene and Sodium methanolate. The specific synthesis steps are as follows:
A solution of 1-bromo-3-chloro-5-fluoro-benzene (42a, 55 g, 263 mmol) was cooled to 0° C. and treated with a 25percent methanolic sodium methoxide solution (68 mL, 315 mmol) and heated to 40° C. for 3 h. The solution was cooled and partitioned between water (1 L) and a 1:1 mixture of hexane/diethyl ether (3.x.200 mL). The combined extracts were washed with brine (60 mL), dried (Na2SO4), filtered and the solvents evaporated in vacuo to afford 42b as an oil (57.3 g, 92percent pure, 238 mmol). The ether 42b (43 g, 173 mmol) was treated with glacial HOAc (150 mL) and 48percent aqueous HBr (100 mL) and heated to 120° C. After 40 h, the volatiles were removed while heated to 80° C. and then cooled to RT. The residue was partitioned between water (100 mL) and DCM (3.x.250 mL). The combined extracts were washed with H2O (50 mL), aqueous NaHCO3solution (2.x.50 mL), brine (50 mL), and (MgSO4). The solvents were removed to afford 23.3 g of 1-Bromo-3-chloro-5-methoxybenzene as a grey solid.

References

[1] Patent: US2006/25462, 2006, A1. Location in patent: Page/Page column 16-17
[2] Patent: WO2015/187089, 2015, A1. Location in patent: Page/Page column 62; 63
[3] Patent: US2007/105872, 2007, A1. Location in patent: Page/Page column 29
[4] Patent: WO2004/31178, 2004, A1. Location in patent: Page 25
[5] Patent: WO2004/29051, 2004, A1. Location in patent: Page 33

1-BROMO-3-CHLORO-5-METHOXYBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-BROMO-3-CHLORO-5-METHOXYBENZENE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-Bromo-3-chloro-5-methoxybenzene 174913-12-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Career Henan Chemical Co

Product: 1-BROMO-3-CHLORO-5-METHOXYBENZENE 174913-12-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

174913-12-3, 1-BROMO-3-CHLORO-5-METHOXYBENZENERelated Search:

2-Bromo-4-chloro-6-fluorotoluene 3-Bromo-2-iodotoluene 2-BROMO-4-METHYLBENZOTRIFLUORIDE 3-fluoro-5-iodobenzodifluoride 1-BROMO-2,3-DIFLUORO-5-METHYLBENZENE 2-BROMO-4-CHLORO-6-NITROTOLUENE 2-bromo-6-chloro-3-fluorotoluene 2,6-Dichloro-4-fluorobenzotrifluoride 2-Chloro-3-fluorobenzotrifluoride 2,6-Dibromobenzotrifluoride 2-CHLORO-4-FLUOROBENZOTRIFLUORIDE 2,4-Dibromo-6-fluorotoluene 3-Bromo-5-chlorophenol 2-Chloro-4-bromo-6-trifluoromethoxyaniline 4-bromo-6-chlorobenzo[d]oxazol-2(3H)-one 1-BROMO-3-CHLORO-5-METHOXYBENZENE

1-BROMO-3-CHLORO-5-METHOXYBENZENE

3-Bromo-5-chloroanisole

Benzene, 1-bromo-3-chloro-5-methoxy-

Phloroglucinol Impurity 34

3-bromo-5-chlorotrifluoromethoxybenzene

1-BROMO-3-CHLORO-5-METHOXYBENZENE ISO 9001：2015 REACH

Phloroglucinol Impurity 56

3-chloro-5-bromobenzyl ether

174913-12-3