1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID
- Product Name
- 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID
- CAS No.
- 898746-35-5
- Chemical Name
- 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID
- Synonyms
- 7-Azaindole-6-carboxylic ...;7-AZAINDOLE-6-CARBOXYLIC ACID;1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID
- CBNumber
- CB1117831
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 898746-35-5.mol
1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID Property
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.44±0.30(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C8H6N2O2/c11-8(12)6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H,9,10)(H,11,12)
- InChIKey
- LDJMQIKMKHNGDB-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=CC=C(C(O)=O)N=2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B530493
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-6-carboxylicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR927275
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-6-carboxylicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 068577
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid
- Purity
- >95%
- Packaging
- 250mg
- Price
- $213
- Updated
- 2021/12/16
- Product number
- OR927275
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-6-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 068577
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
189882-33-5
898746-35-5
General procedure for the synthesis of 7-azaindole-6-carboxylic acid from 6-cyano-7-azaindole: 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile (120 mg, 0.84 mmol) was dissolved in ethanol (10 mL). To the solution was added 6 N sodium hydroxide solution (1.4 mL, 8.4 mmol) and the reaction mixture was stirred at 90 °C for 18 hours. Upon completion of the reaction, the mixture was distilled under reduced pressure to remove the solvent. Subsequently, a 1 N hydrochloric acid solution was added to the residue for acidification. The acidified solution was extracted with ethyl acetate. The organic phases were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by column chromatography to afford the target product 7-azaindole-6-carboxylic acid (100 mg, 74% yield). The nuclear magnetic resonance hydrogen spectrum (1H-NMR, 400 MHz, DMSO-d6) data were as follows: δ 12.08 (broad single peak, 1H), 8.11 (double peak, 1H), 7.83 (double peak, 1H), 7.70 (double peak, 1H), 6.58 (double peak, 1H).
References
[1] Patent: WO2014/73904, 2014, A1. Location in patent: Paragraph 942-945
[2] Patent: WO2012/95463, 2012, A1. Location in patent: Page/Page column 80
[3] Patent: CN104387385, 2016, B. Location in patent: Paragraph 0040-0045
1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID manufacturers
- Product
- 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID 898746-35-5
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04